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Gene Review

uvrC  -  excinuclease UvrABC, endonuclease subunit

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1912, JW1898
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Disease relevance of uvrC


High impact information on uvrC


Chemical compound and disease context of uvrC


Biological context of uvrC

  • Plasmids carrying this PstI fragment, in either orientation (pGY3233, pGY4211) relative to the cloning vehicle, complement uvrC mutants [14].
  • The regulatory region of the Escherichia coli uvrC gene has been analysed by the subcloning of appropriate restriction fragments into the promoter probe vector pPV502 [15].
  • Analysis of the regulatory elements of the Escherichia coli uvrC gene by construction of operon fusions [15].
  • Using the phi X174 RF DNA-E. coli transfection system, we have found that BPDE-I or BPDE-II modified phi X174 RF DNA has much lower transfectivity in uvrA, uvrB, and uvrC mutant cells compared to wild type cells [16].
  • We have sequenced the control region of the uvrC protein including two open reading frames (ORF) encoding polypeptides of 28 kd and 23 kd molecular weight [17].

Associations of uvrC with chemical compounds

  • We find that the uvrC gene is preceded by three promoters (P1, P2 and P3), identified by heparin-resistant RNA polymerase-DNA complex formation, P2 and P3 promoters are located proximal to the 5' end of the uvrC gene, while the P1 promoter is separated from the uvrC structural gene by an interposed DNA region of more than 1 kb [18].
  • Further experiments indicated that chloroquine-induced reversion frequencies were essentially identical in wild-type, recA, umuC and uvrC derivatives of DG1669, as well as in strains carrying the mutation enhancing plasmid pKM101, over a wide range of doses (0-1200 micrograms/plate) [19].

Physical interactions of uvrC

  • The addition of the uvrD protein to the incised DNA-uvrABC complex also results in turnover of only the uvrC protein [20].

Other interactions of uvrC


  1. Regulation of the uvrC gene of Escherichia coli K12: localization and characterization of a damage-inducible promoter. van Sluis, C.A., Moolenaar, G.F., Backendorf, C. EMBO J. (1983) [Pubmed]
  2. Organisation and control of the Escherichia coli uvrC gene. Forster, J.W., Strike, P. Gene (1985) [Pubmed]
  3. uvrC gene function has no specific role in repair of N-2-aminofluorene adducts. Bichara, M., Fuchs, R.P. J. Bacteriol. (1987) [Pubmed]
  4. Structure of the Haemophilus influenzae uvr-1+ gene: homology with other uvrC-like genes and characterization of the Haemophilus influenzae uvr-1 and uvr-2 mutations. Gottschalk, V.A., Stuy, J.H. SAAS Bull. Biochem. Biotechnol. (1997) [Pubmed]
  5. Chromosomal location of the Bacillus subtilis aspartokinase II gene and nucleotide sequence of the adjacent genes homologous to uvrC and trx of Escherichia coli. Chen, N.Y., Zhang, J.J., Paulus, H. J. Gen. Microbiol. (1989) [Pubmed]
  6. Biochemical analysis of UV mutagenesis in Escherichia coli by using a cell-free reaction coupled to a bioassay: identification of a DNA repair-dependent, replication-independent pathway. Cohen-Fix, O., Livneh, Z. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  7. The C-terminal half of UvrC protein is sufficient to reconstitute (A)BC excinuclease. Lin, J.J., Sancar, A. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  8. mutA and mutC: two mutator loci in Escherichia coli that stimulate transversions. Michaels, M.L., Cruz, C., Miller, J.H. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  9. Specificity of mutagenesis by 4-aminobiphenyl. A possible role for N-(deoxyadenosin-8-yl)-4-aminobiphenyl as a premutational lesion. Lasko, D.D., Harvey, S.C., Malaikal, S.B., Kadlubar, F.F., Essigmann, J.M. J. Biol. Chem. (1988) [Pubmed]
  10. The structural gene for AMP nucleosidase. Mapping, cloning, and overproduction of the enzyme. Leung, H.B., Schramm, V.L. J. Biol. Chem. (1984) [Pubmed]
  11. Removal of UV light-induced pyrimidine-pyrimidone(6-4) products from Escherichia coli DNA requires the uvrA, uvrB, and urvC gene products. Franklin, W.A., Haseltine, W.A. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  12. uvrC gene function in excision repair in toluene-treated Escherichia coli. Sharma, S., Moses, R.E. J. Bacteriol. (1979) [Pubmed]
  13. Repair of damage induced by SR 4233. Edwards, D.I., Virk, N.S. Int. J. Radiat. Oncol. Biol. Phys. (1992) [Pubmed]
  14. Isolation of plasmids carrying either the uvrC or uvrC uvrA and ssb genes of Escherichia coli K-12. Yoakum, G.H., Kushner, S.R., Grossman, L. Gene (1980) [Pubmed]
  15. Analysis of the regulatory elements of the Escherichia coli uvrC gene by construction of operon fusions. Forster, J.W., Strike, P. Mol. Gen. Genet. (1988) [Pubmed]
  16. Differences and similarities in the repair of two benzo[a]pyrene diol epoxide isomers induced DNA adducts by uvrA, uvrB, and uvrC gene products. Tang, M.S., Pierce, J.R., Doisy, R.P., Nazimiec, M.E., MacLeod, M.C. Biochemistry (1992) [Pubmed]
  17. Multiple control elements for the uvrC gene unit of Escherichia coli. Sharma, S., Stark, T.F., Beattie, W.G., Moses, R.E. Nucleic Acids Res. (1986) [Pubmed]
  18. Distal regulatory functions for the uvrC gene of E. coli. Sharma, S., Stark, T., Moses, R.E. Nucleic Acids Res. (1984) [Pubmed]
  19. Frameshift mutagenesis by chloroquine in Escherichia coli and Salmonella typhimurium. Thomas, S.M., Silburn, K.A., MacPhee, D.G. Mutat. Res. (1987) [Pubmed]
  20. The involvement of an E. coli multiprotein complex in the complete repair of UV-damaged DNA. Grossman, L., Caron, P.R., Oh, E.Y. Basic Life Sci. (1986) [Pubmed]
  21. Cloning and genetic analysis of the UV resistance determinant (uvr) encoded on the Enterococcus faecalis pheromone-responsive conjugative plasmid pAD1. Ozawa, Y., Tanimoto, K., Fujimoto, S., Tomita, H., Ike, Y. J. Bacteriol. (1997) [Pubmed]
  22. DNA damage-dependent recruitment of nucleotide excision repair and transcription proteins to Escherichia coli inner membranes. Lin, C.G., Kovalsky, O., Grossman, L. Nucleic Acids Res. (1997) [Pubmed]
  23. Nucleotide excision repair proteins may be involved in the fixation of glyoxal-induced mutagenesis in Escherichia coli. Murata-Kamiya, N., Kamiya, H., Kaji, H., Kasai, H. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
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