The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

IL27RA  -  interleukin 27 receptor, alpha

Homo sapiens

Synonyms: CRL1, Cytokine receptor WSX-1, Cytokine receptor-like 1, IL-27 receptor subunit alpha, IL-27R, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of IL27RA


High impact information on IL27RA

  • Here we report a new member of the type I cytokine receptor family, designated T-cell cytokine receptor (TCCR) [3].
  • Nine CDDP-resistant clones independently derived from murine stem cell virus-infected WM35 cells were analyzed and it was found that five of these clones acquired an identical retroviral integration site, designated as CDDP resistance locus 1 (CRL-1), as revealed by isolation of retroviral flanking sequences [5].
  • These data indicated that the preferential activation of STAT3 in fully activated CD4(+) T cells plays an important role in the cytokine suppression by IL-27/WSX-1 [6].
  • WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27 [7].
  • IL-27 stimulation induced STAT1 phosphorylation in wild-type but not in WSX-1-deficient naive CD4(+) T cells [8].

Biological context of IL27RA


Anatomical context of IL27RA


Associations of IL27RA with chemical compounds

  • To explore the role of WSX-1 in this model, WSX-1(-/-) mice were immunized with interphotoreceptor retinoid-binding protein peptide 1-20 to induce EAU [2].
  • The palladium-catalyzed three-component coupling reaction (TCCR) of aryl isocyanides, allyl methyl carbonate, and trimethylsilyl azide was conducted in the presence of Pd(2)(dba)(3).CHCl(3) (2.5 mol %) and dppe (1,2-bis(diphenylphosphino)ethane) (10 mol %) [10].


  1. Identification of polymorphisms in human interleukin-27 and their association with asthma in a Korean population. Chae, S.C., Li, C.S., Kim, K.M., Yang, J.Y., Zhang, Q., Lee, Y.C., Yang, Y.S., Chung, H.T. J. Hum. Genet. (2007) [Pubmed]
  2. WSX-1 plays a significant role for the initiation of experimental autoimmune uveitis. Sonoda, K.H., Yoshimura, T., Takeda, A., Ishibashi, T., Hamano, S., Yoshida, H. Int. Immunol. (2007) [Pubmed]
  3. Development of Th1-type immune responses requires the type I cytokine receptor TCCR. Chen, Q., Ghilardi, N., Wang, H., Baker, T., Xie, M.H., Gurney, A., Grewal, I.S., de Sauvage, F.J. Nature (2000) [Pubmed]
  4. T helper 1-inducing property of IL-27/WSX-1 signaling is required for the induction of experimental colitis. Honda, K., Nakamura, K., Matsui, N., Takahashi, M., Kitamura, Y., Mizutani, T., Harada, N., Nawata, H., Hamano, S., Yoshida, H. Inflamm. Bowel Dis. (2005) [Pubmed]
  5. Retroviral insertional mutagenesis as a strategy for the identification of genes associated with cis-diamminedichloroplatinum(II) resistance. Lu, S.J., Man, S., Bani, M.R., Adachi, D., Hawley, R.G., Kerbel, R.S., Ben-David, Y. Cancer Res. (1995) [Pubmed]
  6. Two-Sided Roles of IL-27: Induction of Th1 Differentiation on Naive CD4+ T Cells versus Suppression of Proinflammatory Cytokine Production Including IL-23-Induced IL-17 on Activated CD4+ T Cells Partially Through STAT3-Dependent Mechanism. Yoshimura, T., Takeda, A., Hamano, S., Miyazaki, Y., Kinjyo, I., Ishibashi, T., Yoshimura, A., Yoshida, H. J. Immunol. (2006) [Pubmed]
  7. WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27. Pflanz, S., Hibbert, L., Mattson, J., Rosales, R., Vaisberg, E., Bazan, J.F., Phillips, J.H., McClanahan, T.K., de Waal Malefyt, R., Kastelein, R.A. J. Immunol. (2004) [Pubmed]
  8. Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment. Takeda, A., Hamano, S., Yamanaka, A., Hanada, T., Ishibashi, T., Mak, T.W., Yoshimura, A., Yoshida, H. J. Immunol. (2003) [Pubmed]
  9. Cloning and characterization of a novel class I cytokine receptor. Sprecher, C.A., Grant, F.J., Baumgartner, J.W., Presnell, S.R., Schrader, S.K., Yamagiwa, T., Whitmore, T.E., O'Hara, P.J., Foster, D.F. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  10. Synthesis of allyl cyanamides and N-cyanoindoles via the palladium-catalyzed three-component coupling reaction. Kamijo, S., Yamamoto, Y. J. Am. Chem. Soc. (2002) [Pubmed]
WikiGenes - Universities