Disease relevance of IL27RA

• Although signaling of IL-27/WSX-1 interactions have been recognized in the down-regulation of airway hyper-reactivity and in lung inflammation during the development of allergic asthma, little is known about the role of single nucleotide polymorphisms (SNPs) of IL-27 and individual susceptibility to asthma [1].
• WSX-1 plays a significant role for the initiation of experimental autoimmune uveitis [2].
• TCCR-deficient mice also had increased susceptibility to infection with an intracellular pathogen, Listeria monocytogenes [3].
• Second, we induced DSS colitis in WSX-1 KO and wild-type (WT) mice [4].
• As a result, IL-27/WSX-1 signal pathway may thus be a promising candidate for the therapeutic intervention of human inflammatory bowel diseases such as Crohn's disease and ulcerative colitis [4].

High impact information on IL27RA

• Here we report a new member of the type I cytokine receptor family, designated T-cell cytokine receptor (TCCR) [3].
• Nine CDDP-resistant clones independently derived from murine stem cell virus-infected WM35 cells were analyzed and it was found that five of these clones acquired an identical retroviral integration site, designated as CDDP resistance locus 1 (CRL-1), as revealed by isolation of retroviral flanking sequences [5].
• These data indicated that the preferential activation of STAT3 in fully activated CD4(+) T cells plays an important role in the cytokine suppression by IL-27/WSX-1 [6].
• WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27 [7].
• IL-27 stimulation induced STAT1 phosphorylation in wild-type but not in WSX-1-deficient naive CD4(+) T cells [8].

Biological context of IL27RA

• STAT1 interacts with tyrosine-phosphorylated WSX-1, and the conserved tyrosine residue of the cytoplasmic domain of WSX-1 is essential for transcriptional activation of STAT1 [8].
• A novel class I cytokine receptor was identified in a human infant brain cDNA library and was named WSX-1 [9].

Anatomical context of IL27RA

• The IL-27 cytokine is mediated by one of the receptor chains (WSX-1) of the IL-27 receptor that is highly expressed on CD4(+) T lymphocytes and NK cells [1].
• In addition, sub-retinal transfer of lymphocytes from WSX-1(-/-) mice on day 9 after immunization did not induce EAU in the recipient mice [2].
• Northern blot analysis indicates high levels of expression in thymus, spleen, lymph node, and peripheral blood leukocytes, suggesting a role for WSX-1 in modulation of the immune response [9].

Associations of IL27RA with chemical compounds

• To explore the role of WSX-1 in this model, WSX-1(-/-) mice were immunized with interphotoreceptor retinoid-binding protein peptide 1-20 to induce EAU [2].
• The palladium-catalyzed three-component coupling reaction (TCCR) of aryl isocyanides, allyl methyl carbonate, and trimethylsilyl azide was conducted in the presence of Pd(2)(dba)(3).CHCl(3) (2.5 mol %) and dppe (1,2-bis(diphenylphosphino)ethane) (10 mol %) [10].

References