The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Il27ra  -  interleukin 27 receptor, alpha

Mus musculus

Synonyms: CRL1, IL-27 receptor subunit alpha, IL-27R, IL-27R subunit alpha, IL-27R-alpha, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Il27ra


High impact information on Il27ra

  • Although recent studies have described IL-27 and its receptor, WSX-1, as promoters of Th1 differentiation in naive CD4+ T cells, the data presented here indicate that signaling through this receptor is involved in limiting the intensity and duration of T cell activity [6].
  • Massive necroinflammatory lesions were observed in the liver of infected WSX-1-/- mice, and IFN-gamma that was overproduced in WSX-1-/- mice compared with wild-type mice was responsible for the lesions [7].
  • In addition, vast amounts of various proinflammatory cytokines, including IL-6 and TNF-alpha, were produced by liver mononuclear cells in WSX-1-/- mice [7].
  • The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection [6].
  • WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of proinflammatory cytokine production [7].

Chemical compound and disease context of Il27ra


Biological context of Il27ra


Anatomical context of Il27ra

  • In the absence of WSX-1, an increased production of the proinflammatory cytokines TNF and IL-12p40 resulted in elevated CD4+ T cell activation and IFN-gamma production, which enhanced macrophage effector functions and reduced bacterial loads [12].
  • Expression of WSX-1, one subunit of IL-27R, was detected at the mRNA level in primary mouse spleen B cells, and stimulation of these B cells by IL-27 rapidly activated STAT1 [13].
  • Positive and negative regulation of the IL-27 receptor during lymphoid cell activation [5].
  • Production of Th2 cytokines, which are largely responsible for the pathogenesis of asthma, was augmented in the lung or in the culture supernatants of peribronchial lymph node CD4+ T cells from WSX-1(-/-) mice compared with those from wild-type mice [3].
  • Additionally, since high levels of WSX-1 are evident on resting NK cells, resting NKT cells, effector T cells, regulatory T cells, and memory T cells, the current work demonstrates that IL-27 can influence multiple effector cells of innate and adaptive immunity [5].

Associations of Il27ra with chemical compounds

  • To explore the role of WSX-1 in this model, WSX-1(-/-) mice were immunized with interphotoreceptor retinoid-binding protein peptide 1-20 to induce EAU [14].

Regulatory relationships of Il27ra

  • Previous reports have focused on the ability of IL-27 to promote naive T cell responses but the present study reveals that surface expression of WSX-1, the ligand-specific component of the IL-27R, is low on these cells and that highest levels are found on effector and memory CD4(+) and CD8(+) T cells [5].
  • Surprisingly, IFN-gamma production was also enhanced in WSX-1(-/-) mice, albeit at a low concentration [3].
  • The cytokine overproduction, thus, seems independent from the Th1-promoting property of WSX-1 [3].
  • Importantly, WSX-1 over-expression failed to suppress T(h)2 cytokine production under T(h)2-polarizing conditions [11].

Other interactions of Il27ra

  • In mice deficient for the WSX-1 gene, proper Th1 differentiation was impaired and abnormal Th2 skewing was observed during infection with some intracellular pathogens [1].
  • The initial mounting of Th1 responses depends on the function of the WSX-1 gene, which encodes a subunit of the IL-27R with homology to IL-12R [1].
  • WSX-1 (IL-27R) is a class I cytokine receptor with homology to gp130 and IL-12 receptors and is typically expressed on CD4+ T lymphocytes [3].
  • These data revealed a novel role for WSX-1 as an inhibitory regulator of cytokine production and inflammation in Con A-induced hepatitis [15].
  • Unexpectedly, like activated CD4(+) T cells from WSX-1(-/-) mice, activated CD4(+) T cells from WSX-1 Tg mice showed increased proliferation, augmented IL-2 production and up-regulated surface expression of activation markers [11].

Analytical, diagnostic and therapeutic context of Il27ra

  • Adoptive cell transfer and cell depletion studies revealed that CD4(+) T cells were involved in mediating liver immunopathology and controlling L. donovani growth in TCCR-/- mice [4].


  1. Membranous glomerulonephritis development with Th2-type immune deviations in MRL/lpr mice deficient for IL-27 receptor (WSX-1). Shimizu, S., Sugiyama, N., Masutani, K., Sadanaga, A., Miyazaki, Y., Inoue, Y., Akahoshi, M., Katafuchi, R., Hirakata, H., Harada, M., Hamano, S., Nakashima, H., Yoshida, H. J. Immunol. (2005) [Pubmed]
  2. WSX-1: a key role in induction of chronic intestinal nematode infection. Bancroft, A.J., Humphreys, N.E., Worthington, J.J., Yoshida, H., Grencis, R.K. J. Immunol. (2004) [Pubmed]
  3. Exacerbation of experimental allergic asthma by augmented Th2 responses in WSX-1-deficient mice. Miyazaki, Y., Inoue, H., Matsumura, M., Matsumoto, K., Nakano, T., Tsuda, M., Hamano, S., Yoshimura, A., Yoshida, H. J. Immunol. (2005) [Pubmed]
  4. Interleukin-27R (WSX-1/T-cell cytokine receptor) gene-deficient mice display enhanced resistance to leishmania donovani infection but develop severe liver immunopathology. Rosas, L.E., Satoskar, A.A., Roth, K.M., Keiser, T.L., Barbi, J., Hunter, C., de Sauvage, F.J., Satoskar, A.R. Am. J. Pathol. (2006) [Pubmed]
  5. Positive and negative regulation of the IL-27 receptor during lymphoid cell activation. Villarino, A.V., Larkin, J., Saris, C.J., Caton, A.J., Lucas, S., Wong, T., de Sauvage, F.J., Hunter, C.A. J. Immunol. (2005) [Pubmed]
  6. The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection. Villarino, A., Hibbert, L., Lieberman, L., Wilson, E., Mak, T., Yoshida, H., Kastelein, R.A., Saris, C., Hunter, C.A. Immunity (2003) [Pubmed]
  7. WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of proinflammatory cytokine production. Hamano, S., Himeno, K., Miyazaki, Y., Ishii, K., Yamanaka, A., Takeda, A., Zhang, M., Hisaeda, H., Mak, T.W., Yoshimura, A., Yoshida, H. Immunity (2003) [Pubmed]
  8. WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection. Yoshida, H., Hamano, S., Senaldi, G., Covey, T., Faggioni, R., Mu, S., Xia, M., Wakeham, A.C., Nishina, H., Potter, J., Saris, C.J., Mak, T.W. Immunity (2001) [Pubmed]
  9. Cutting edge: early IL-4 production governs the requirement for IL-27-WSX-1 signaling in the development of protective Th1 cytokine responses following Leishmania major infection. Artis, D., Johnson, L.M., Joyce, K., Saris, C., Villarino, A., Hunter, C.A., Scott, P. J. Immunol. (2004) [Pubmed]
  10. Analysis of cytokine regulators inducing interferon production by mouse uterine natural killer cells. Zhang, J.H., He, H., Borzychowski, A.M., Takeda, K., Akira, S., Croy, B.A. Biol. Reprod. (2003) [Pubmed]
  11. WSX-1 over-expression in CD4(+) T cells leads to hyperproliferation and cytokine hyperproduction in response to TCR stimulation. Takeda, A., Hamano, S., Shiraishi, H., Yoshimura, T., Ogata, H., Ishii, K., Ishibashi, T., Yoshimura, A., Yoshida, H. Int. Immunol. (2005) [Pubmed]
  12. The IL-27 receptor chain WSX-1 differentially regulates antibacterial immunity and survival during experimental tuberculosis. Hölscher, C., Hölscher, A., Rückerl, D., Yoshimoto, T., Yoshida, H., Mak, T., Saris, C., Ehlers, S. J. Immunol. (2005) [Pubmed]
  13. Induction of IgG2a class switching in B cells by IL-27. Yoshimoto, T., Okada, K., Morishima, N., Kamiya, S., Owaki, T., Asakawa, M., Iwakura, Y., Fukai, F., Mizuguchi, J. J. Immunol. (2004) [Pubmed]
  14. WSX-1 plays a significant role for the initiation of experimental autoimmune uveitis. Sonoda, K.H., Yoshimura, T., Takeda, A., Ishibashi, T., Hamano, S., Yoshida, H. Int. Immunol. (2007) [Pubmed]
  15. Hyperproduction of proinflammatory cytokines by WSX-1-deficient NKT cells in concanavalin A-induced hepatitis. Yamanaka, A., Hamano, S., Miyazaki, Y., Ishii, K., Takeda, A., Mak, T.W., Himeno, K., Yoshimura, A., Yoshida, H. J. Immunol. (2004) [Pubmed]
WikiGenes - Universities