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Gene Review

CYTIP  -  cytohesin 1 interacting protein

Homo sapiens

Synonyms: B3-1, CASP, CYBR, CYTHIP, Cbp HE, ...
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Disease relevance of PSCDBP

  • But P. radiora RP-C, P. fluorescens B3-1, E. coli B/r and E. coli K-12 were hardly sensitized by N2O [1].

High impact information on PSCDBP

  • Acceleration of guanosine 5prime prime or minute-O-(thiotriphosphate) binding to ARF by cytohesin-1 in vitro was enhanced by Cybr [2].
  • However, competitive stem cell repopulation experiments showed a defect in the abilities of Cybr-deficient T cells to develop in the presence of wild-type precursors [3].
  • Cytohesin binder and regulator (cybr) is not essential for T- and dendritic-cell activation and differentiation [3].
  • These data suggest that Cybr is not absolutely required for hematopoietic cell development or function, but stem cells lacking Cybr are at a developmental disadvantage compared to wild-type cells [3].
  • Despite the selective expression in hematopoietic cells, there was no intrinsic defect in T- or B-cell development or function in Cybr-deficient mice [3].

Biological context of PSCDBP

  • Assignment of the human B3-1 gene (PSCDBP) to chromosome 2 band q11.2 by radiation hybrid mapping [4].
  • The effects of Cybr on nuclear factor of activated T cells and AP-1 are dependent on MAPK activation, and enhanced activation of this cascade results in cooperation between the two transcription factors in the regulation of gene expression [5].
  • A 1724 base pair (bp) clone, B3-1, was obtained from a human NK subtracted cDNA library and sequenced [6].
  • METHOD: A sample of 12 research papers on support for breast-feeding was appraised by six qualitative reviewers using three appraisal methods: unprompted judgement, based on expert opinion; a UK Cabinet Office quality framework; and CASP, a Critical Appraisal Skills Programme tool [7].

Anatomical context of PSCDBP

  • Yeast two-hybrid screening of a B cell library using the cytohesin N terminus as bait, identified CASP, a scaffolding protein of previously unknown function, as a binding partner [8].
  • CASP contains an internal coiled coil motif that is required for cytohesin binding both in vitro and in COS-1 cells [8].
  • Here we show that Cybr mRNA and protein levels are increased upon T cell receptor engagement [5].
  • Cybr protein associates with members of the cytohesin family, which are known ADP-ribosylation factors-GDP/GTP exchange factors, and its functions appear to regulate lymphocyte adhesion and cell-cell contact [5].
  • All fragments gave rise to at least some colonies, but colony-forming ability was mostly marked in the intermediate part (B2) and the lower half of the central part (B3-1); approximately 60% of colony-forming cells of a hair follicle localized to the fragment B3-1 and 28% to the fragment B3-2 (upper half of the central part, including bulge) [9].

Associations of PSCDBP with chemical compounds


Other interactions of PSCDBP


Analytical, diagnostic and therapeutic context of PSCDBP

  • In immunofluorescence experiments, CASP localizes to perinuclear tubulovesicular structures that are in close proximity to the Golgi [8].
  • CYTIP, which is induced during maturation of DCs, shortly accumulates to the contact zones with T cells within the first hour of coculture [10].
  • The adoptive transfer of Cybr-deficient DCs showed that they migrated efficiently and stimulated proliferation and cytokine production by T cells in vivo [3].
  • By microdissection, five fragments of the outer root sheath (B1, B2, B3-1, B3-2, B4) were separated, dispersed by trypsin into single cell suspensions, and grown on human feeder fibroblasts [9].
  • However, the allele-specific LC PCR with CYBR green 1 method is most rapid, easier to perform, and least expensive technique, and it can be readily performed in most molecular diagnostic laboratories [11].


  1. The role of cellular catalase on the radiosensitization of bacterial vegetative cells by N2O. Watanabe, H., Takehisa, M., Iizuka, H. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. (1983) [Pubmed]
  2. Cybr, a cytokine-inducible protein that binds cytohesin-1 and regulates its activity. Tang, P., Cheng, T.P., Agnello, D., Wu, C.Y., Hissong, B.D., Watford, W.T., Ahn, H.J., Galon, J., Moss, J., Vaughan, M., O'Shea, J.J., Gadina, M. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  3. Cytohesin binder and regulator (cybr) is not essential for T- and dendritic-cell activation and differentiation. Watford, W.T., Li, D., Agnello, D., Durant, L., Yamaoka, K., Yao, Z.J., Ahn, H.J., Cheng, T.P., Hofmann, S.R., Cogliati, T., Chen, A., Hissong, B.D., Husa, M.R., Schwartzberg, P., O'Shea, J.J., Gadina, M. Mol. Cell. Biol. (2006) [Pubmed]
  4. Assignment of the human B3-1 gene (PSCDBP) to chromosome 2 band q11.2 by radiation hybrid mapping. Kim, H.S. Cytogenet. Cell Genet. (1999) [Pubmed]
  5. Cytohesin binder and regulator augments T cell receptor-induced nuclear factor of activated T Cells.AP-1 activation through regulation of the JNK pathway. Chen, Q., Coffey, A., Bourgoin, S.G., Gadina, M. J. Biol. Chem. (2006) [Pubmed]
  6. Cloning a cDNA from human NK/T cells which codes for an unusual leucine zipper containing protein. Dixon, B., Sahely, B., Liu, L., Pohajdak, B. Biochim. Biophys. Acta (1993) [Pubmed]
  7. Appraising qualitative research for inclusion in systematic reviews: a quantitative and qualitative comparison of three methods. Dixon-Woods, M., Sutton, A., Shaw, R., Miller, T., Smith, J., Young, B., Bonas, S., Booth, A., Jones, D. Journal of health services research & policy (2007) [Pubmed]
  8. The N-terminal coiled coil domain of the cytohesin/ARNO family of guanine nucleotide exchange factors interacts with the scaffolding protein CASP. Mansour, M., Lee, S.Y., Pohajdak, B. J. Biol. Chem. (2002) [Pubmed]
  9. Proliferative potential of different keratinocytes of plucked human hair follicles. Moll, I. J. Invest. Dermatol. (1995) [Pubmed]
  10. Dendritic cells regulate T-cell deattachment through the integrin-interacting protein CYTIP. Hofer, S., Pfeil, K., Niederegger, H., Ebner, S., Nguyen, V.A., Kremmer, E., Auffinger, M., Neyer, S., Fürhapter, C., Heufler, C. Blood (2006) [Pubmed]
  11. BRAF mutation analysis in fine needle aspiration (FNA) cytology of the thyroid. Jin, L., Sebo, T.J., Nakamura, N., Qian, X., Oliveira, A., Majerus, J.A., Johnson, M.R., Lloyd, R.V. Diagn. Mol. Pathol. (2006) [Pubmed]
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