Disease relevance of Iguanas

• Cellular and extracellular dehydration, and angiotensin as stimuli to drinking in the common iguana Iguana iguana [1].
• PROCEDURE: Anesthesia was induced in 4 iguanas with propofol (10 mg/kg [4.5 mg/lb] of body weight, intraosseously) [2].
• The results of this investigation demonstrated that experimental iguanas fed diets low in calcium developed hypocalcemia and compensatory hyperparathyroidism resulting in progressive osteoporosis due to osteoclastic and osteocytic osteolysis [3].

High impact information on Iguanas

• Corticosterone levels predict survival probabilities of Galapagos marine iguanas during El Nino events [4].
• We evaluated the rate of isomerization of previtamin D3 to vitamin D3 in the skin of iguanas and found the isomerization rate was enhanced by 1100% and 1700% at 25 degrees C and 5 degrees C, respectively [5].
• Frogs have unique pyrimidine base-specific RNases, with structures similar to those of turtle, iguana and chicken RNases [6].
• 2. In response to systemic injections of hypertonic solutions of NaCl and sucrose, the iguana drank and retained enough water to dilute the injected load to isotonicity irrespective of whether water was offered immediately or after 3 hr, and irrespective of whether the solute was administered I.V. or I.P. 3 [1].
• The iguana RNase is expressed primarily in pancreas, and represents the majority of the specific enzymatic activity in this tissue [7].

Biological context of Iguanas

• Circadian rhythm of iguana electroretinogram: the role of dopamine and melatonin [8].
• The C. subcristatus sequence Tcs1 is present in multiple copies in both its host genome (Galapagos land iguana) and the genome of the related Galapagos marine iguana (A. cristatus) [9].
• OBJECTIVE: To determine the pharmacokinetics of ceftiofur sodium after IM and SC administration in green iguanas [10].
• The pineal complex and melatonin affect the expression of the daily rhythm of behavioral thermoregulation in the green iguana [11].
• OBJECTIVE: To assess the cardiovascular effects (arterial blood pressure, heart rate, and metabolic acid-base status) of three doses (MAC multiples) of isoflurane alone and combined with butorphanol in the green iguana (Iguana iguana) [12].

Anatomical context of Iguanas

• Cerebrospinal fluid (CSF)-contacting bipolar neurons in the lizards Anolis carolinensis and Iguana iguana were immunolabeled with antisera generated against vertebrate retinal opsins and vasoactive intestinal polypeptide (VIP) [13].
• Calcitonin gene-related peptide relaxes cholecystokinin-induced tension in Iguana iguana gallbladder strips [14].

Associations of Iguanas with chemical compounds

• Steroid hormones and aggression in female Galápagos marine iguanas [15].
• ND4 to leucine tRNA sequence data were collected from multiple individuals of each of the eight species of Cyclura (including 15 of 16 subspecies) and from four localities of Iguana iguana (representative of this species' broad geographic range) [16].
• The cardiac anesthetic index of isoflurane in green iguanas [17].
• Ten additional iguanas were given propofol intraosseously for induction (5 mg/kg [2.3 mg/lb] and maintenance (0.5 mg/kg/min [0.23 mg/lb/min], q 30 min) of anesthesia [2].
• CONCLUSIONS AND CLINICAL RELEVANCE: A suggested dosing schedule for ceftiofur sodium in green iguanas for microbes susceptible at > 2 microg/mL would be 5 mg/kg, IM or SC, every 24 hours [10].

Gene context of Iguanas

• Complementary DNA and putative gene sequences for iguana Y3 (iY3) and iguana Y4 (iY4) Ro RNAs have been determined and used, along with previously sequenced human and frog Ro YRNA sequences, to construct the most likely Y3 and Y4 RNA secondary structures [18].
• Iguana ribonuclease contains no carbohydrate, although the enzyme possesses three recognition sites for carbohydrate attachment, and has a high number of acidic residues in a localized part of the sequence [19].
• The phylogenetic analysis suggests that basic L-FABP from catfish, chicken and iguana diverged from the mammalian protein before the fish-tetrapod divergence, thus implying that the two types are encoded by different genes [20].
• All the brain extracts except those from the trout, goldfish, and iguana demonstrated the presence of IR-CGRP [21].
• The link between parathyroid hormone and renal disease in humans has been well documented and, given the high prevalence of clinical (and subclinical) secondary nutritional hyperparathyroidism in iguanas, this certainly warrants further investigation in saurians [31,32,34,35] [22].

Analytical, diagnostic and therapeutic context of Iguanas

• PROCEDURE: In a crossover design, 5 iguanas received a single dose of ceftiofur sodium (5 mg/kg) IM, and 5 iguanas received the same dose SC [10].

References