Disease relevance of Research Personnel

• PATIENTS AND OTHER PARTICIPANTS--A sample of 23 patients with chronic fatigue syndrome (five men and 18 women; mean age, 34 years), each of whom fulfilled the strict diagnostic criteria of the Centers for Disease Control and Prevention, was recruited from regional chronic fatigue support groups and from the investigators' clinical practices [1].
• The availability of antibodies reactive with antigens expressed only by hematopoietic cells has provided clinical investigators with new tools for use in developing therapies for acute myeloid leukemia (AML) [2].
• The identification of new agents active against small-cell lung cancer (SCLC) remains a high priority for clinical investigators [3].
• This ability to determine easily the long-term blood glucose should enable the clinical investigator to gain insights into the relationship of glycemia and the complications resulting from long-standing diabetes mellitus [4].
• This model of fulminant hepatic failure induced by acetaminophen and its modulation with ranitidine provides clinical investigators with a research tool that will be useful in the future investigation of putative medical and surgical therapies being investigated for use in the clinical management of fulminant hepatic failure [5].

High impact information on Research Personnel

• Cyclosporin and the clinical investigator [6].
• Citation for the 1996 Rhône-Poulenc Rorer Clinical Investigator Award of The Endocrine Society to Andrea Dunaif [7].
• Larsen, an active clinical investigator at the University of Southern California School of Medicine, to review his current recommendations for the use of the azoles in AIDS patients [8].
• Examples of agents currently in clinical trials that illustrate some of the challenges presented to clinical investigators include monoterpenes such as perillyl alcohol (POH), vitamin D analogs, flavones such as flavopiridol, and angiogenesis inhibitors [9].
• Clinical investigators recently have studied at least 21 new antiepileptic drugs (AEDs) in people with epilepsy [10].

Biological context of Research Personnel

• The former led clinical investigators to claim a false emergence of drug resistance after one year's treatment with a potent antileprosy drug, B663, which was almost abandoned for later clinical use [11].
• Mary's Medical Center, were asked to be clinical investigators for a comparison study of the current Hepcon System Four (HSF) and the next generation Hemostasis Management System (HMS) manufactured by HemoTec, Inc. The HSF has been in place at St [12].

Associations of Research Personnel with chemical compounds

• Coincident with this deficiency of experimental guidance, the independent clinical investigator has developed an array of therapeutic strategies applying different doses and sequences of cisplatin and radiation to a variety of tumor types [13].
• Significant improvement was observed in the investigators' Clinical Global Impression (CGI) score for 57% of patients taking paroxetine and 52% on amitriptyline [14].
• In general, this group of clinical investigators uses the steroids primarily out of tradition, feeling that steroid therapy may be of some benefit [15].
• Hydroxymethylglutaryl coenzyme a reductase inhibition: fluvastatin, a clinical investigators' update. Introduction [16].
• Cefaclor, a new semisynthetic cephalosporin antibiotic for oral use, was studied by 62 clinical investigators in six countries in 1493 adult and paediatric patients [17].

Gene context of Research Personnel

• The next wave of clinical studies will provide clinical investigators with opportunities to develop and evaluate P-glycoprotein tests and correlate test results with clinical outcomes [18].
• Polycystic ovary syndrome (PCOS) is a complex and heterogeneous disorder presenting a challenge for clinical investigators [19].
• The National Cancer Institute Organ Systems Program-sponsored Upper Aerodigestive Cancer Task Force workshops are specifically designed to enhance interactions between basic science and clinical investigators and between academic institutions and the community, and ultimately will contribute to more expeditious clinical advances [20].
• The cloning and expression of human IL-1 gene products has enabled clinical investigators to expand the role of IL-1 in various diseases through improved detection systems and by use of cDNA or cRNA probes [21].
• Clinical investigators studying anabolic drugs such as PTH should be aware of potential long-term interactions of bisphosphonates when assessing the outcome of their experiments [22].

Analytical, diagnostic and therapeutic context of Research Personnel

• For the clinical investigator, the success of chelation therapy with deferoxamine should prompt an intensive search for new chelators [23].

References