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MeSH Review


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Disease relevance of Cryosurgery


High impact information on Cryosurgery

  • RESULTS: The MTD for patients who did not undergo cryosurgery was 100 mg/m2 of irinotecan weekly for 3 weeks every 4 weeks with concurrent HAI FUDR (0.16 mg/kg/d x pump volume/flow rate) plus dexamethasone for 14 days of a 28-day cycle [6].
  • Cryoablations were from 4 to 8 min long at -75 degrees C. Acute end points were noninducibility of AVNRT by programmed atrial stimulation at baseline or during isoproterenol performed 30 min after procedure, as well as noninducibility and conduction block over the AP [7].
  • Seventy-eight women with CIN 1-, CIN 2-, and CIN 3-grade lesions were treated with either an MVA E2 recombinant virus vaccine or with cryosurgery [8].
  • CONCLUSION: Image-guided percutaneous cryoablation of small (< or = 4-cm) renal lesions appears to require less analgesia than RF ablation [9].
  • Cryoablation was associated with a significantly lower dose of fentanyl (165.0 microg [RF group] vs 75.0 microg [cryoablation group]; P < .001) and midazolam (2.9 mg [RF group] vs 1.6 mg [cryoablation group]; P = .026) [9].

Chemical compound and disease context of Cryosurgery


Biological context of Cryosurgery


Anatomical context of Cryosurgery

  • Specific immunity to the MCA-10 line following tumor cryosurgery was demonstrated since lymphocytes and sera from cryosurgically treated tumor-bearing mice were not cytotoxic to a different methylcholanthrene-induced sarcoma (MCAP) in C57 mice or a malignant melanoma (S91) being transferred in Balb/C mice [17].
  • Two patients had epicardial cryoablation of the isthmus between the inferior vena cava and the tricuspid valve annulus [18].
  • In conclusion, administration of IGF-1 can facilitate the regeneration of NOS-containing nerve fibers in penile tissue and enhance the recovery of erectile function after bilateral cavernous nerve cryoablation [19].
  • The polysaccharide treatment significantly reduced the production of IL-4 and IL-10 following cryoablation; the production of TNF-alpha and INF-gamma was slightly promoted; the natural killer and cytotoxic T-cell activities of splenocytes were slightly enhanced [11].
  • These results indicated that, the stromas and then the squamous and columnar epithelial cells in turn were regenerated after CO2-laser treatment, and that the regeneration occurred earlier after laser treatment than after cryosurgery [20].

Associations of Cryosurgery with chemical compounds

  • CONCLUSION: Gadolinium-enhanced MR imaging of the prostate after cryosurgery provides a highly accurate means of monitoring success [21].
  • Several methods have been developed, including intratumoral injection of ethanol or acetic acid, and thermal ablation with radiofrequency, laser, microwaves, or cryosurgery [22].
  • PURPOSE: Laparoscopic renal cryoablation is a nephron sparing treatment alternative for selected patients with small renal tumors [23].
  • RESULTS: PSA was undetectable at 6 months in 48% of patients who received no androgen deprivation therapy following cryosurgery [24].
  • We report that freezing facilitates bleomycin penetration into cells making it toxic to cryosurgery surviving cells at concentrations that are non-toxic systemically [25].

Gene context of Cryosurgery


Analytical, diagnostic and therapeutic context of Cryosurgery


  1. Prostate cryoablation: update 1998. Schmidt, J.D., Doyle, J., Larison, S. CA: a cancer journal for clinicians. (1998) [Pubmed]
  2. Cryosurgical ablation of hepatic tumors. Crews, K.A., Kuhn, J.A., McCarty, T.M., Fisher, T.L., Goldstein, R.M., Preskitt, J.T. Am. J. Surg. (1997) [Pubmed]
  3. Aprotinin inhibits local platelet trapping and improves tissue destruction in hepatic cryosurgery. Kollmar, O., Richter, S., Czyborra, J., Menger, M.D., Dietrich, S., Schilling, M.K., Kirsch, C.M., Pistorius, G.A. Surgery (2004) [Pubmed]
  4. A comparison of intralesional triamcinolone and cryosurgery in the treatment of acne keloids. Layton, A.M., Yip, J., Cunliffe, W.J. Br. J. Dermatol. (1994) [Pubmed]
  5. Verrucous carcinoma of the penis. Successful treatment with cryosurgery and topical fluorouracil therapy. Carson, T.E. Archives of dermatology. (1978) [Pubmed]
  6. Phase I study of hepatic arterial infusion of floxuridine and dexamethasone with systemic irinotecan for unresectable hepatic metastases from colorectal cancer. Kemeny, N., Gonen, M., Sullivan, D., Schwartz, L., Benedetti, F., Saltz, L., Stockman, J., Fong, Y., Jarnagin, W., Bertino, J., Tong, W., Paty, P. J. Clin. Oncol. (2001) [Pubmed]
  7. Transvenous cryothermal catheter ablation of re-entry circuit located near the atrioventricular junction in pediatric patients: efficacy, safety, and midterm follow-up. Drago, F., De Santis, A., Grutter, G., Silvetti, M.S. J. Am. Coll. Cardiol. (2005) [Pubmed]
  8. Therapeutic vaccination with MVA E2 can eliminate precancerous lesions (CIN 1, CIN 2, and CIN 3) associated with infection by oncogenic human papillomavirus. Corona Gutierrez, C.M., Tinoco, A., Navarro, T., Contreras, M.L., Cortes, R.R., Calzado, P., Reyes, L., Posternak, R., Morosoli, G., Verde, M.L., Rosales, R. Hum. Gene Ther. (2004) [Pubmed]
  9. Pain control requirements for percutaneous ablation of renal tumors: cryoablation versus radiofrequency ablation--initial observations. Allaf, M.E., Varkarakis, I.M., Bhayani, S.B., Inagaki, T., Kavoussi, L.R., Solomon, S.B. Radiology. (2005) [Pubmed]
  10. Nitrous oxide cryosurgery applied to skin cancers. Boullie, M.C. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. (1997) [Pubmed]
  11. Antitumor effects of residual tumor after cryoablation: the combined effect of residual tumor and a protein-bound polysaccharide on multiple liver metastases in a murine model. Urano, M., Tanaka, C., Sugiyama, Y., Miya, K., Saji, S. Cryobiology (2003) [Pubmed]
  12. Resurfacing of facial angiofibromas in tuberous sclerosis patients using CO2 laser with flashscanner. Song, M.G., Park, K.B., Lee, E.S. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. (1999) [Pubmed]
  13. Local platelet trapping as the cause of thrombocytopenia after hepatic cryotherapy. Pistorius, G.A., Alexander, C., Krisch, C.M., Feifel, G., Schilling, M.K., Menger, M.D. World journal of surgery. (2005) [Pubmed]
  14. A pilot study of cryochemotherapy for hepatic metastases from colorectal cancer. Rodríguez-Bigas, M.A., Klippenstein, D., Meropol, N.J., Weber, T.K., Petrelli, N.J. Cryobiology (1996) [Pubmed]
  15. Directed laparoscopic cryomyolysis: a possible alternative to myomectomy and/or hysterectomy for symptomatic leiomyomas. Zupi, E., Piredda, A., Marconi, D., Townsend, D., Exacoustos, C., Arduini, D., Szabolcs, B. Am. J. Obstet. Gynecol. (2004) [Pubmed]
  16. Effects of scalpel (with and without tissue adhesive) and cryosurgery on wound healing in rat tongues. Camacho-Alonso, F., López-Jornet, P., Bermejo-Fenoll, A. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. (2005) [Pubmed]
  17. In vitro demonstration of cryosurgical augmentation of tumor immunity. Faraci, R.P., Bagley, D.H., Marrone, J., Beazley, R.M. Surgery (1975) [Pubmed]
  18. Atrial flutter: lessons from surgical interventions (musing on atrial flutter mechanism). Guiraudon, G.M., Klein, G.J., van Hemel, N., Guiraudon, C.M., de Bakker, J.M. Pacing and clinical electrophysiology : PACE. (1996) [Pubmed]
  19. Effect of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 complex in cavernous nerve cryoablation. Bochinski, D., Hsieh, P.S., Nunes, L., Lin, G.T., Lin, C.S., Spencer, E.M., Lue, T.F. Int. J. Impot. Res. (2004) [Pubmed]
  20. Wound healing process in the portio vaginalis uteri after CO2-laser treatment. Hoshi, K., Honda, S., Endo, C., Sato, A., Sekimoto, S. Tohoku J. Exp. Med. (1993) [Pubmed]
  21. Prostatic cryosurgery: use of MR imaging in evaluation of success and technical modifications. Vellet, A.D., Saliken, J., Donnelly, B., Raber, E., McLaughlin, R.F., Wiseman, D., Ali-Ridha, N.H. Radiology. (1997) [Pubmed]
  22. Percutaneous ablation of hepatocellular carcinoma: state-of-the-art. Lencioni, R., Cioni, D., Crocetti, L., Bartolozzi, C. Liver Transpl. (2004) [Pubmed]
  23. Histopathology of human renal tumors after laparoscopic renal cryosurgery. Jang, T.L., Wang, R., Kim, S.C., Troe, T., Pins, M.R., Nadler, R.B. J. Urol. (2005) [Pubmed]
  24. Cryosurgical treatment of localized prostate cancer (stages T1 to T4): preliminary results. Shinohara, K., Connolly, J.A., Presti, J.C., Carroll, P.R. J. Urol. (1996) [Pubmed]
  25. Treatment of cancer with cryochemotherapy. Mir, L.M., Rubinsky, B. Br. J. Cancer (2002) [Pubmed]
  26. Immunologic response to cryoablation of breast cancer. Sabel, M.S., Nehs, M.A., Su, G., Lowler, K.P., Ferrara, J.L., Chang, A.E. Breast Cancer Res. Treat. (2005) [Pubmed]
  27. Serum response of hepatocyte growth factor, insulin-like growth factor-I, interleukin-6, and acute phase proteins in patients with colorectal liver metastases treated with partial hepatectomy or cryosurgery. de Jong, K.P., von Geusau, B.A., Rottier, C.A., Bijzet, J., Limburg, P.C., de Vries, E.G., Fidler, V., Slooff, M.J. J. Hepatol. (2001) [Pubmed]
  28. Active rectal wall protection using direct transperineal cryo-needles for histologically proven prostate adenocarcinomas. Cytron, S., Paz, A., Kravchick, S., Shumalinski, D., Moore, J. Eur. Urol. (2003) [Pubmed]
  29. Complement depletion enhances pulmonary inflammatory response after liver injury. Glasgow, S.C., Kanakasabai, S., Ramachandran, S., Mohanakumar, T., Chapman, W.C. J. Gastrointest. Surg. (2006) [Pubmed]
  30. Prostate cancer: gadolinium-enhanced MR imaging at 3 weeks compared with needle biopsy at 6 months after cryoablation. Donnelly, S.E., Donnelly, B.J., Saliken, J.C., Raber, E.L., Vellet, A.D. Radiology. (2004) [Pubmed]
  31. Treatment of organ confined prostate cancer with third generation cryosurgery: preliminary multicenter experience. Han, K.R., Cohen, J.K., Miller, R.J., Pantuck, A.J., Freitas, D.G., Cuevas, C.A., Kim, H.L., Lugg, J., Childs, S.J., Shuman, B., Jayson, M.A., Shore, N.D., Moore, Y., Zisman, A., Lee, J.Y., Ugarte, R., Mynderse, L.A., Wilson, T.M., Sweat, S.D., Zincke, H., Belldegrun, A.S. J. Urol. (2003) [Pubmed]
  32. The efficacy of cryosurgical ablation of prostate cancer: the University of California, San Francisco experience. Koppie, T.M., Shinohara, K., Grossfeld, G.D., Presti, J.C., Carroll, P.R. J. Urol. (1999) [Pubmed]
  33. Nonsurgical treatment of hepatocellular carcinoma. Aguayo, A., Patt, Y.Z. Semin. Oncol. (2001) [Pubmed]
  34. Treatment of nonmelanoma skin cancer in organ transplant recipients: review of responses to a survey. Clayton, A.S., Stasko, T. J. Am. Acad. Dermatol. (2003) [Pubmed]
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