Disease relevance of Embolism, Fat

• Prostanoid production and pulmonary hypertension after fat embolism are not modified by methylprednisolone [1].
• Methylprednisolone given prophylactically may reduce the incidence of fat embolism syndrome and can reduce the degree of hypoxemia associated with long bone fractures of the lower extremmity [2].
• We present a case of FES (fat embolism syndrome) with very serious neurologic signs (convulsions, deep coma, decerebrate response to noxious stimuli), without lung lesions [3].
• BACKGROUND: Cerebral fat embolism syndrome is a rare, but potentially lethal, complication of long bone fractures [4].
• A prolonged noradrenaline activity is to be expected in surgical stress states, e.g. multiple injuries, fat embolism syndrome, burns and infections; therapeutic approaches to minimize the sympathoadrenal activity are outlined [5].

High impact information on Embolism, Fat

• Fatal pulmonary and cerebral fat embolism in systemic lupus erythematosus [6].
• Sickling crisis, fat embolism, and coma after steroids [7].
• Encephalopathy associated with fat embolism induced by solvent for cyclosporin [8].
• It is suggested that non-traumatic fat embolism may be caused by agglutination of chylomicrons and VLDL by high levels of plasma CRP [9].
• We conclude that, in the oleic acid or fat embolism model of pulmonary injury, methylprednisolone significantly increases resolution of the pulmonary injury presumably by stimulation of active proliferation and maturation of Type II pneumocytes [10].

Chemical compound and disease context of Embolism, Fat

• Cyclosporin encephalopathy associated with fat embolism induced by the drug's solvent [11].
• Glyceryl trioleate has been injected into greyhounds as a model of the fat embolism syndrome [12].
• Experimental fat embolism induces urine 2,3-dinor-6-ketoprostaglandin F1alpha and 11-dehydrothromboxane B2 excretion in pigs [13].
• Oleic acid infusion, as a model of fat embolism, produces a predominantly peripheral lesion in the dog lung [14].
• In patients with fat embolism, the levels of non-esterified plasma fatty acids, cGMP, 5-hydroxytryptamine (serotonin) and nitrates/nitrites were increased during pulmonary oedema [15].

Gene context of Embolism, Fat

• CONCLUSIONS: Cerebral fat embolism after long-bone fractures can be detected in vivo and monitored over time with the use of transcranial Doppler techniques [16].
• However, fat embolism was not associated with a more severe clinical course, suggesting that bronchoscopy and BAL have little impact on the management of these patients [17].
• Fat embolism associated with an atrial septal defect [18].
• Our findings confirm that MRI can detect cerebral fat embolism with a higher sensitivity than CCT [19].
• An early increase in the alpha1 lipbrotein fraction was noted in the fat embolism patients simultaneously with a decrease in the pre-beta lipoprotein fraction; the values of the other trauma patients were at the control levels [20].

Analytical, diagnostic and therapeutic context of Embolism, Fat

• PURPOSE: The purpose of this study was to evaluate the cerebral hemodynamic change in the hyperacute stage of cerebral fat embolism induced by triolein emulsion, by using MR perfusion imaging in cat brains [21].
• Using a combination of frozen section with oil red O staining and formalin-fixed osmium stained tissues, the immediate cause of death was determined to be diffuse fat embolism [22].
• Prolonged and frequent bedside EEG recordings will demonstrate better these fluctuating abnormalities in cerebral fat embolism (and probably in coma of other origin) than standard less frequent recordings [23].

References