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Gene Review

RRP8  -  ribosomal RNA processing 8,...

Homo sapiens

Synonyms: Cerebral protein 1, KIAA0409, NML, Nucleomethylin, Ribosomal RNA-processing protein 8, ...
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Disease relevance of KIAA0409


Psychiatry related information on KIAA0409


High impact information on KIAA0409


Chemical compound and disease context of KIAA0409

  • The Controlled trial of Aspirin in Cerebral Ischemia compared aspirin (650 mg twice daily) with placebo in medically and surgically treated groups of patients who had experienced transient ischemic attacks [16].
  • METHODS: Cerebral vasomotor reactivity was assessed using transcranial Doppler ultrasonology and the Diamox test (intravenous administration of 1.0 g acetazolamide) in 44 asymptomatic patients with severe (> 70%) internal carotid artery stenosis [17].
  • These findings support the hypothesis that estrogen attenuates stimulation of BBB Na-K-Cl cotransporter activity, reducing edema formation during stroke.Journal of Cerebral Blood Flow & Metabolism (2006) 26, 1234-1249. doi:10.1038/sj.jcbfm.9600278; published online 18 January 2006 [18].
  • Eight normal male volunteers (not suffering from migraine) received 0.5 mg ergotamine and 1 mg dihydroergotamine i.v. Cerebral blood flow was measured by the xenon-133 inhalation method and single-photon-emission computerized tomography before and after intravenous acetazolamide administration (1 g) [19].
  • RESULTS: Cerebral vasomotor reactivity was estimated as good (> 40% increase of blood flow velocity in the middle cerebral artery ipsilateral to the carotid stenosis after undergoing the Diamox test) in 23 patients; it was impaired in the other 21 [17].

Biological context of KIAA0409


Anatomical context of KIAA0409


Associations of KIAA0409 with chemical compounds

  • Lithium carbonate and brain function. I. Cerebral-evoked potentials, EEG, and symptom changes during lithium carbonate treatment [30].
  • TNF Is Important for Pathogen Control and Limits Brain Damage in Murine Cerebral Listeriosis [31].
  • METHOD: Cerebral glucose utilization, as determined by position emission tomography (PET), was studied in 18 male schizophrenic subjects before and after chronic treatment with haloperidol at a standardized plasma level [32].
  • METHODS: Cerebral blood flow before and after 1 g acetazolamide was analyzed by 99mTc-HMPAO-SPECT in 21 symptomatic patients with documented extracranial obstructions [33].
  • The authors investigated the relationship between total cholesterol, high-density lipoprotein (HDL), their ratio, and cerebral CO2 reactivity in 826 participants from the Rotterdam Study. Cerebral CO2 reactivity increased significantly with increasing levels of HDL and decreased significantly with an increasing total cholesterol/HDL ratio [34].

Regulatory relationships of KIAA0409


Other interactions of KIAA0409

  • Our data show that the time window of BMSC therapy is at least 1 month after stroke; the interaction of SDF-1/CXCR4 may contribute to the trafficking of transplanted BMSCs.Journal of Cerebral Blood Flow & Metabolism (2007) 27, 6-13. doi:10.1038/sj.jcbfm.9600311; published online 5 April 2006 [36].
  • An animal model for the molecular genetics of CADASIL. (Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) [37].
  • These findings indicate TACE proteolysis as a promoter of stroke-induced SVZ progenitor cell neurogenesis, and suggest this protease activity may represent an attractive therapeutic target for stroke recovery.Journal of Cerebral Blood Flow & Metabolism (2007) 27, 669-678. doi:10.1038/sj.jcbfm.9600390; published online 23 August 2006 [38].
  • BACKGROUND: The MERCI (Mechanical Embolus Removal in Cerebral Ischemia) trial reported efficacy of the Merci Retriever for opening intracranial vessels in patients ineligible for intravenous (IV) tissue plasminogen activator (tPA) [39].
  • All of their heights were under "mean-4.0 S.D.". Cerebral tomography of brothers and their mother all showed "empty sella", and GH-releasing hormone (GRH) tests showed no responses of GH not only to bolus intravenous injections but also after repeated intramuscular injections of GRH (100 micrograms/day) for 7 days [40].

Analytical, diagnostic and therapeutic context of KIAA0409


  1. Images in clinical medicine. Cerebral venous thrombosis. Jaffer, A., Leifer, D. N. Engl. J. Med. (1997) [Pubmed]
  2. Letter: Cerebral metastases and carcinoembryonic antigen in CSF. Snitzer, L.S., McKinney, E.C., Tejada, F., Sigel, M.M., Rosomoff, H.L., Zubrod, C.G. N. Engl. J. Med. (1975) [Pubmed]
  3. Risk factors for cerebral edema in children with diabetic ketoacidosis. The Pediatric Emergency Medicine Collaborative Research Committee of the American Academy of Pediatrics. Glaser, N., Barnett, P., McCaslin, I., Nelson, D., Trainor, J., Louie, J., Kaufman, F., Quayle, K., Roback, M., Malley, R., Kuppermann, N. N. Engl. J. Med. (2001) [Pubmed]
  4. Cerebral sinovenous thrombosis in children. deVeber, G., Andrew, M., Adams, C., Bjornson, B., Booth, F., Buckley, D.J., Camfield, C.S., David, M., Humphreys, P., Langevin, P., MacDonald, E.A., Gillett, J., Meaney, B., Shevell, M., Sinclair, D.B., Yager, J. N. Engl. J. Med. (2001) [Pubmed]
  5. Images in clinical medicine. Cerebral histoplasmosis. Tabbal, S.D., Harik, S.I. N. Engl. J. Med. (1999) [Pubmed]
  6. Longitudinal PET Evaluation of Cerebral Metabolic Decline in Dementia: A Potential Outcome Measure in Alzheimer's Disease Treatment Studies. Alexander, G.E., Chen, K., Pietrini, P., Rapoport, S.I., Reiman, E.M. The American journal of psychiatry. (2002) [Pubmed]
  7. Mitochondrial dysfunction associated with a mutation in the Notch3 gene in a CADASIL family. de la Peña, P., Bornstein, B., del Hoyo, P., Fernández-Moreno, M.A., Martín, M.A., Campos, Y., Gómez-Escalonilla, C., Molina, J.A., Cabello, A., Arenas, J., Garesse, R. Neurology (2001) [Pubmed]
  8. Neuropsychological impairment correlates with hypoperfusion and hypometabolism but not with severity of white matter lesions on MRI in patients with cerebral microangiopathy. Sabri, O., Ringelstein, E.B., Hellwig, D., Schneider, R., Schreckenberger, M., Kaiser, H.J., Mull, M., Buell, U. Stroke (1999) [Pubmed]
  9. Cerebral abnormalities in myotonic dystrophy. Cerebral blood flow, magnetic resonance imaging, and neuropsychological tests. Chang, L., Anderson, T., Migneco, O.A., Boone, K., Mehringer, C.M., Villanueva-Meyer, J., Berman, N., Mena, I. Arch. Neurol. (1993) [Pubmed]
  10. Creutzfeldt-Jakob disease and cerebral amyloid angiopathy. Gray, F., Chrétien, F., Cesaro, P., Chatelain, J., Beaudry, P., Laplanche, J.L., Mikol, J., Bell, J., Gambetti, P., Degos, J.D. Acta Neuropathol. (1994) [Pubmed]
  11. Images in clinical medicine. Cerebral arteriovenous malformation. Lee, K., Holman, B.L. N. Engl. J. Med. (1995) [Pubmed]
  12. Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism. Furlan, A., Higashida, R., Wechsler, L., Gent, M., Rowley, H., Kase, C., Pessin, M., Ahuja, A., Callahan, F., Clark, W.M., Silver, F., Rivera, F. JAMA (1999) [Pubmed]
  13. Silent embolism in diagnostic cerebral angiography and neurointerventional procedures: a prospective study. Bendszus, M., Koltzenburg, M., Burger, R., Warmuth-Metz, M., Hofmann, E., Solymosi, L. Lancet (1999) [Pubmed]
  14. Increased risk of cerebral venous sinus thrombosis with third-generation oral contraceptives. Cerebral Venous Sinus Thrombosis Study Group. de Bruijn, S.F., Stam, J., Vandenbroucke, J.P. Lancet (1998) [Pubmed]
  15. Prediction of recovery from post-traumatic vegetative state with cerebral magnetic-resonance imaging. Kampfl, A., Schmutzhard, E., Franz, G., Pfausler, B., Haring, H.P., Ulmer, H., Felber, S., Golaszewski, S., Aichner, F. Lancet (1998) [Pubmed]
  16. Summary of design features: clinical trials of platelet-active drugs in cerebrovascular disease. Friedman, L.M. Circulation (1980) [Pubmed]
  17. Is impaired cerebral vasomotor reactivity a predictive factor of stroke in asymptomatic patients? Gur, A.Y., Bova, I., Bornstein, N.M. Stroke (1996) [Pubmed]
  18. Estradiol reduces activity of the blood-brain barrier Na-K-Cl cotransporter and decreases edema formation in permanent middle cerebral artery occlusion. O'donnell, M.E., Lam, T.I., Tran, L.Q., Foroutan, S., Anderson, S.E. J. Cereb. Blood Flow Metab. (2006) [Pubmed]
  19. The effect of ergotamine and dihydroergotamine on cerebral blood flow in man. Andersen, A.R., Tfelt-Hansen, P., Lassen, N.A. Stroke (1987) [Pubmed]
  20. Cerebral oedema and increased intracranial pressure in chronic liver disease. Donovan, J.P., Schafer, D.F., Shaw, B.W., Sorrell, M.F. Lancet (1998) [Pubmed]
  21. The magnitude of the central response to esophageal electrical stimulation is intensity dependent. Hollerbach, S., Kamath, M.V., Chen, Y., Fitzpatrick, D., Upton, A.R., Tougas, G. Gastroenterology (1997) [Pubmed]
  22. Determinants of cerebral oxygenation during cardiac surgery. Nollert, G., Möhnle, P., Tassani-Prell, P., Reichart, B. Circulation (1995) [Pubmed]
  23. Abnormalities of regional distribution of cerebral vasculature in schizophrenia detected by dynamic susceptibility contrast MRI. Cohen, B.M., Yurgelun-Todd, D., English, C.D., Renshaw, P.F. The American journal of psychiatry. (1995) [Pubmed]
  24. Images in neuroscience. Brain development, III. Cerebral cortex. Roberts, R.C. The American journal of psychiatry. (1998) [Pubmed]
  25. Circulatory management with retrograde cerebral perfusion for acute type A aortic dissection. Bavaria, J.E., Woo, Y.J., Hall, R.A., Wahl, P.M., Acker, M.A., Gardner, T.J. Circulation (1996) [Pubmed]
  26. Cerebral and corpus callosum atrophy in systemic lupus erythematosus. Appenzeller, S., Rondina, J.M., Li, L.M., Costallat, L.T., Cendes, F. Arthritis Rheum. (2005) [Pubmed]
  27. Middle cerebral artery occlusion due to hydatid cysts of myocardial and intraventricular cavity cardiac origin. Two cases. Benomar, A., Yahyaoui, M., Birouk, N., Vidailhet, M., Chkili, T. Stroke (1994) [Pubmed]
  28. Time course of symptoms in extracranial carotid artery dissections. A series of 80 patients. Biousse, V., D'Anglejan-Chatillon, J., Touboul, P.J., Amarenco, P., Bousser, M.G. Stroke (1995) [Pubmed]
  29. Grading of cerebral dynamic autoregulation from spontaneous fluctuations in arterial blood pressure. Panerai, R.B., White, R.P., Markus, H.S., Evans, D.H. Stroke (1998) [Pubmed]
  30. Lithium carbonate and brain function. I. Cerebral-evoked potentials, EEG, and symptom changes during lithium carbonate treatment. Heninger, G.R. Arch. Gen. Psychiatry (1978) [Pubmed]
  31. TNF Is Important for Pathogen Control and Limits Brain Damage in Murine Cerebral Listeriosis. Virna, S., Deckert, M., Lütjen, S., Soltek, S., Foulds, K.E., Shen, H., Körner, H., Sedgwick, J.D., Schlüter, D. J. Immunol. (2006) [Pubmed]
  32. Blunted change in cerebral glucose utilization after haloperidol treatment in schizophrenic patients with prominent negative symptoms. Wolkin, A., Sanfilipo, M., Duncan, E., Angrist, B., Wolf, A.P., Cooper, T.B., Brodie, J.D., Laska, E., Rotrosen, J.P. The American journal of psychiatry. (1996) [Pubmed]
  33. 99mTc-HMPAO-SPECT with acetazolamide challenge to detect hemodynamic compromise in occlusive cerebrovascular disease. Knop, J., Thie, A., Fuchs, C., Siepmann, G., Zeumer, H. Stroke (1992) [Pubmed]
  34. Cerebral CO2 reactivity, cholesterol, and high-density lipoprotein cholesterol in the elderly. Bakker, S.L., de Leeuw, F.E., Koudstaal, P.J., Hofman, A., Breteler, M.M. Neurology (2000) [Pubmed]
  35. Use of a Poly(ADP-Ribose) Polymerase Inhibitor to Suppress Inflammation and Neuronal Death After Cerebral Ischemia-Reperfusion. Hamby, A.M., Suh, S.W., Kauppinen, T.M., Swanson, R.A. Stroke (2007) [Pubmed]
  36. Therapeutic benefit of bone marrow stromal cells administered 1 month after stroke. Shen, L.H., Li, Y., Chen, J., Zacharek, A., Gao, Q., Kapke, A., Lu, M., Raginski, K., Vanguri, P., Smith, A., Chopp, M. J. Cereb. Blood Flow Metab. (2007) [Pubmed]
  37. An animal model for the molecular genetics of CADASIL. (Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy). Fryxell, K.J., Soderlund, M., Jordan, T.V. Stroke (2001) [Pubmed]
  38. Stroke-induced subventricular zone proliferation is promoted by tumor necrosis factor-alpha-converting enzyme protease activity. Katakowski, M., Chen, J., Zhang, Z.G., Santra, M., Wang, Y., Chopp, M. J. Cereb. Blood Flow Metab. (2007) [Pubmed]
  39. Safety of mechanical thrombectomy and intravenous tissue plasminogen activator in acute ischemic stroke. Results of the multi Mechanical Embolus Removal in Cerebral Ischemia (MERCI) trial, part I. Smith, W.S. AJNR. American journal of neuroradiology. (2006) [Pubmed]
  40. A family case with autosomal-dominantly inherited pituitary dwarfism. Tani, N., Kaneko, K., Momotsu, T., Takasawa, T., Ito, S., Shibata, A., Miki, T., Tateishi, H., Kumahara, Y. Tohoku J. Exp. Med. (1987) [Pubmed]
  41. Predictive value of Glasgow coma score for awakening after out-of-hospital cardiac arrest. Cerebral Resuscitation Study Group of the Belgian Society for Intensive Care. Mullie, A., Verstringe, P., Buylaert, W., Houbrechts, H., Michem, N., Delooz, H., Verbruggen, H., Van den Broeck, L., Corne, L., Lauwaert, D. Lancet (1988) [Pubmed]
  42. Anterior paralimbic mediation of procaine-induced emotional and psychosensory experiences. Ketter, T.A., Andreason, P.J., George, M.S., Lee, C., Gill, D.S., Parekh, P.I., Willis, M.W., Herscovitch, P., Post, R.M. Arch. Gen. Psychiatry (1996) [Pubmed]
  43. Regional cerebral blood flow in familial hypercholesterolemia. Rodriguez, G., Bertolini, S., Nobili, F., Arrigo, A., Masturzo, P., Elicio, N., Gambaro, M., Rosadini, G. Stroke (1994) [Pubmed]
  44. Macrovascular contribution in activation patterns of working memory. Tomasi, D.G., Caparelli, E.C. J. Cereb. Blood Flow Metab. (2007) [Pubmed]
  45. Outcome of carotid artery occlusion is predicted by cerebrovascular reactivity. Vernieri, F., Pasqualetti, P., Passarelli, F., Rossini, P.M., Silvestrini, M. Stroke (1999) [Pubmed]
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