Disease relevance of KIAA0409

• Images in clinical medicine. Cerebral venous thrombosis [1].
• Letter: Cerebral metastases and carcinoembryonic antigen in CSF [2].
• BACKGROUND: Cerebral edema is an uncommon but devastating complication of diabetic ketoacidosis in children [3].
• BACKGROUND: Cerebral sinovenous thrombosis in children is a serious disorder, and information is needed about its prevention and treatment [4].
• Images in clinical medicine. Cerebral histoplasmosis [5].

Psychiatry related information on KIAA0409

• Longitudinal PET Evaluation of Cerebral Metabolic Decline in Dementia: A Potential Outcome Measure in Alzheimer's Disease Treatment Studies [6].
• BACKGROUND: Cerebral autosomal arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is characterized by recurrent subcortical ischemic strokes and dementia caused by mutations in the Notch3 gene [7].
• BACKGROUND AND PURPOSE: Cerebral microangiopathy, indicated on MRI by lacunar infarctions (LI) and deep white matter lesions (DWML), is said to lead to vascular dementia [8].
• Cerebral abnormalities in myotonic dystrophy. Cerebral blood flow, magnetic resonance imaging, and neuropsychological tests [9].
• Association of Creutzfeldt-Jakob disease and Cerebral amyloid angiopathy in the absence of Alzheimer changes in unusual [10].

High impact information on KIAA0409

• Images in clinical medicine. Cerebral arteriovenous malformation [11].
• Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism [12].
• BACKGROUND: Cerebral angiography is associated with a small but definite risk of neurological complications with an unknown incidence of clinically silent embolism [13].
• Increased risk of cerebral venous sinus thrombosis with third-generation oral contraceptives. Cerebral Venous Sinus Thrombosis Study Group [14].
• INTERPRETATION: Cerebral MRI findings in the subacute stage after head injury can predict the outcome of the post-traumatic VS [15].

Chemical compound and disease context of KIAA0409

• The Controlled trial of Aspirin in Cerebral Ischemia compared aspirin (650 mg twice daily) with placebo in medically and surgically treated groups of patients who had experienced transient ischemic attacks [16].
• METHODS: Cerebral vasomotor reactivity was assessed using transcranial Doppler ultrasonology and the Diamox test (intravenous administration of 1.0 g acetazolamide) in 44 asymptomatic patients with severe (> 70%) internal carotid artery stenosis [17].
• These findings support the hypothesis that estrogen attenuates stimulation of BBB Na-K-Cl cotransporter activity, reducing edema formation during stroke.Journal of Cerebral Blood Flow & Metabolism (2006) 26, 1234-1249. doi:10.1038/sj.jcbfm.9600278; published online 18 January 2006 [18].
• Eight normal male volunteers (not suffering from migraine) received 0.5 mg ergotamine and 1 mg dihydroergotamine i.v. Cerebral blood flow was measured by the xenon-133 inhalation method and single-photon-emission computerized tomography before and after intravenous acetazolamide administration (1 g) [19].
• RESULTS: Cerebral vasomotor reactivity was estimated as good (> 40% increase of blood flow velocity in the middle cerebral artery ipsilateral to the carotid stenosis after undergoing the Diamox test) in 23 patients; it was impaired in the other 21 [17].

Biological context of KIAA0409

• INTERPRETATION: Cerebral oedema and increased intracranial pressure can occur in chronic liver disease and presents as neurological deterioration [20].
• BACKGROUND & AIMS: Cerebral evoked potential (EP) responses to visceral stimulation represent a powerful method to assess visceral afferent pathways [21].
• CONCLUSIONS: Cerebral oxygenation is autoregulated during cardiac surgery before and after CPB [22].
• RESULTS: Cerebral blood volume was greater in the schizophrenic subjects in every region studied [23].
• Images in neuroscience. Brain development, III. Cerebral cortex [24].

Anatomical context of KIAA0409

• BACKGROUND: Cerebral circulation during urgent repair of acute type A aortic dissection has traditionally been managed with cardiopulmonary bypass and aortic cross clamping proximal to the innominate artery or by the use of hypothermic circulatory arrest (HCA) [25].
• RESULTS: Cerebral and corpus callosum volumes were significantly smaller in patients with SLE compared with healthy volunteers (P < 0.001) [26].
• CASE DESCRIPTIONS: Cerebral angiography demonstrated occlusion of the initial segment of the middle cerebral artery [27].
• BACKGROUND AND PURPOSE: Cerebral infarction is the most frequent and severe manifestation of extracranial internal carotid artery dissection [28].
• METHODS: Cerebral blood flow velocity (determined by transcranial Doppler) and arterial blood pressure (determined by noninvasive servo-controlled plethysmograph) were recorded in 20 patients with carotid artery stenosis and 18 age-matched controls [29].

Associations of KIAA0409 with chemical compounds

• Lithium carbonate and brain function. I. Cerebral-evoked potentials, EEG, and symptom changes during lithium carbonate treatment [30].
• TNF Is Important for Pathogen Control and Limits Brain Damage in Murine Cerebral Listeriosis [31].
• METHOD: Cerebral glucose utilization, as determined by position emission tomography (PET), was studied in 18 male schizophrenic subjects before and after chronic treatment with haloperidol at a standardized plasma level [32].
• METHODS: Cerebral blood flow before and after 1 g acetazolamide was analyzed by 99mTc-HMPAO-SPECT in 21 symptomatic patients with documented extracranial obstructions [33].
• The authors investigated the relationship between total cholesterol, high-density lipoprotein (HDL), their ratio, and cerebral CO2 reactivity in 826 participants from the Rotterdam Study. Cerebral CO2 reactivity increased significantly with increasing levels of HDL and decreased significantly with an increasing total cholesterol/HDL ratio [34].

Regulatory relationships of KIAA0409

• Use of a Poly(ADP-Ribose) Polymerase Inhibitor to Suppress Inflammation and Neuronal Death After Cerebral Ischemia-Reperfusion [35].

Other interactions of KIAA0409

• Our data show that the time window of BMSC therapy is at least 1 month after stroke; the interaction of SDF-1/CXCR4 may contribute to the trafficking of transplanted BMSCs.Journal of Cerebral Blood Flow & Metabolism (2007) 27, 6-13. doi:10.1038/sj.jcbfm.9600311; published online 5 April 2006 [36].
• An animal model for the molecular genetics of CADASIL. (Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) [37].
• These findings indicate TACE proteolysis as a promoter of stroke-induced SVZ progenitor cell neurogenesis, and suggest this protease activity may represent an attractive therapeutic target for stroke recovery.Journal of Cerebral Blood Flow & Metabolism (2007) 27, 669-678. doi:10.1038/sj.jcbfm.9600390; published online 23 August 2006 [38].
• BACKGROUND: The MERCI (Mechanical Embolus Removal in Cerebral Ischemia) trial reported efficacy of the Merci Retriever for opening intracranial vessels in patients ineligible for intravenous (IV) tissue plasminogen activator (tPA) [39].
• All of their heights were under "mean-4.0 S.D.". Cerebral tomography of brothers and their mother all showed "empty sella", and GH-releasing hormone (GRH) tests showed no responses of GH not only to bolus intravenous injections but also after repeated intramuscular injections of GRH (100 micrograms/day) for 7 days [40].

Analytical, diagnostic and therapeutic context of KIAA0409

• Predictive value of Glasgow coma score for awakening after out-of-hospital cardiac arrest. Cerebral Resuscitation Study Group of the Belgian Society for Intensive Care [41].
• METHODS: Cerebral blood flow was assessed by positron emission tomography with oxygen-15-labeled water in 32 healthy volunteers [42].
• CONCLUSIONS: Cerebral perfusion and cerebrovascular reactivity were maintained within the normal range despite long-lasting, severe hypercholesterolemia, even if a somewhat lower CBF was found in those patients with the highest LDL-C pretreatment levels [43].
• This study suggests that the phase information embedded in the MRI signal can be used to suppress unwanted macrovascular contributions in fMRI studies.Journal of Cerebral Blood Flow & Metabolism (2007) 27, 33-42. doi:10.1038/sj.jcbfm.9600314; published online 12 April 2006 [44].
• METHODS: Cerebral hemodynamics were studied with transcranial Doppler ultrasonography [45].

References