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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Multiple Trauma

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Disease relevance of Multiple Trauma


Psychiatry related information on Multiple Trauma

  • Trends were found to suggest that patients sustaining associated multiple trauma also remain in coma longer, and experience more difficulties in social interaction and overall psychosocial functioning, but less difficulties in mobility compared with pure-head-injured patients [6].

High impact information on Multiple Trauma


Chemical compound and disease context of Multiple Trauma


Biological context of Multiple Trauma


Anatomical context of Multiple Trauma


Gene context of Multiple Trauma

  • Both measurement of GFAP and S100B is a useful non-invasive means of identifying brain damage with some differences based on the pattern of TBI and accompanying multiple trauma and/or shock [23].
  • Our data demonstrate elevated levels of systemic IL-11 after multiple injuries; however, the role of a posttraumatic increase of IL-11 has to be further analyzed [24].
  • Association between injury pattern of patients with multiple injuries and circulating levels of soluble tumor necrosis factor receptors, interleukin-6 and interleukin-10, and polymorphonuclear neutrophil elastase [25].
  • Thus, though S 100 B may be a reliable marker of brain damage in TBI without multiple trauma 24 h after trauma and thereafter, it appears to be less reliable in TBI with multiple trauma [26].
  • Plasma GH, IGF-1, insulin, C-peptide, and cortisol levels were measured at 1-hour intervals during 24 hours (8 AM to 8 AM) in 10 severely injured adults with multiple trauma during the early catabolic flow phase 24 to 48 hours after injury, when patients received maintenance fluids without calories or nitrogen [27].

Analytical, diagnostic and therapeutic context of Multiple Trauma


  1. Serum phospholipases A2 in inflammatory diseases. Nevalainen, T.J. Clin. Chem. (1993) [Pubmed]
  2. Changes in carnitine in polymorphonuclear leukocytes, mononuclear cells, and plasma from patients with inflammatory disorders. Adlouni, H.A., Katrib, K., Férard, G. Clin. Chem. (1988) [Pubmed]
  3. Failure of ceftazidime-amikacin therapy for bacteremia and meningitis due to Klebsiella pneumoniae producing an extended-spectrum beta-lactamase. Smith, C.E., Tillman, B.S., Howell, A.W., Longfield, R.N., Jorgensen, J.H. Antimicrob. Agents Chemother. (1990) [Pubmed]
  4. Assessment of urinary retinol-binding protein as an index of proximal tubular injury. Bernard, A.M., Vyskocil, A.A., Mahieu, P., Lauwerys, R.R. Clin. Chem. (1987) [Pubmed]
  5. Enhanced urinary excretion of leukotriene E4 by patients with multiple trauma with or without adult respiratory distress syndrome. Fauler, J., Tsikas, D., Holch, M., Seekamp, A., Nerlich, M.L., Sturm, J., Frölich, J.C. Clin. Sci. (1991) [Pubmed]
  6. Long-term multi-dimensional outcome following isolated traumatic brain injuries and traumatic brain injuries associated with multiple trauma. Moore, A.D., Stambrook, M., Peters, L.C., Cardoso, E.R., Kassum, D.A. Brain injury : [BI]. (1990) [Pubmed]
  7. Randomised trial of glutamine-enriched enteral nutrition on infectious morbidity in patients with multiple trauma. Houdijk, A.P., Rijnsburger, E.R., Jansen, J., Wesdorp, R.I., Weiss, J.K., McCamish, M.A., Teerlink, T., Meuwissen, S.G., Haarman, H.J., Thijs, L.G., van Leeuwen, P.A. Lancet (1998) [Pubmed]
  8. Relationship between admission hyperglycemia and neurologic outcome of severely brain-injured patients. Young, B., Ott, L., Dempsey, R., Haack, D., Tibbs, P. Ann. Surg. (1989) [Pubmed]
  9. Plasma elastase levels and the development of the adult respiratory distress syndrome. Donnelly, S.C., MacGregor, I., Zamani, A., Gordon, M.W., Robertson, C.E., Steedman, D.J., Little, K., Haslett, C. Am. J. Respir. Crit. Care Med. (1995) [Pubmed]
  10. Cimetidine dynamics after repeated intravenous injection. Pancorbo, S., Bubrick, M.P., Chin, T.W., Miller, K.W., Onstad, G. Clin. Pharmacol. Ther. (1984) [Pubmed]
  11. Parenterally administered dipeptide alanyl-glutamine prevents worsening of insulin sensitivity in multiple-trauma patients. Bakalar, B., Duska, F., Pachl, J., Fric, M., Otahal, M., Pazout, J., Andel, M. Crit. Care Med. (2006) [Pubmed]
  12. Death related to propofol use in an adult patient. Perrier, N.D., Baerga-Varela, Y., Murray, M.J. Crit. Care Med. (2000) [Pubmed]
  13. Traumatic avulsion of the innominate and left carotid arteries: successful repair. Wernly, J.A., Campbell, C.D., Replogle, R.L. J. Thorac. Cardiovasc. Surg. (1982) [Pubmed]
  14. Determinants of urea nitrogen production in sepsis. Muscle catabolism, total parenteral nutrition, and hepatic clearance of amino acids. Pittiruti, M., Siegel, J.H., Sganga, G., Coleman, B., Wiles, C.E., Placko, R. Archives of surgery (Chicago, Ill. : 1960) (1989) [Pubmed]
  15. Pharmacokinetics and pharmacodynamics of enoxaparin in multiple trauma patients. Haas, C.E., Nelsen, J.L., Raghavendran, K., Mihalko, W., Beres, J., Ma, Q., Forrest, A. The Journal of trauma. (2005) [Pubmed]
  16. Nicotine inhibits human gingival fibroblast migration via modulation of Rac signalling pathways. Fang, Y., Svoboda, K.K. Journal of clinical periodontology. (2005) [Pubmed]
  17. The influence of hemocoagulative disorders on the outcome of children with head injury. Chiaretti, A., Pezzotti, P., Mestrovic, J., Piastra, M., Polidori, G., Storti, S., Velardi, F., Di Rocco, C. Pediatric neurosurgery. (2001) [Pubmed]
  18. The potential pattern of circulating lymphocytes TH1/TH2 is not altered after multiple injuries. Wick, M., Kollig, E., Muhr, G., Köller, M. Archives of surgery (Chicago, Ill. : 1960) (2000) [Pubmed]
  19. L-selectin in trauma patients: a marker for organ dysfunction and outcome? Kerner, T., Ahlers, O., Spielmann, S., Keh, D., Bührer, C., Gerlach, M., Höfler, S., Gerlach, H. Eur. J. Clin. Invest. (1999) [Pubmed]
  20. Lipopolysaccharide-induced tumor necrosis factor alpha production and not monocyte human leukocyte antigen-DR expression is correlated with survival in septic trauma patients. Ploder, M., Pelinka, L., Schmuckenschlager, C., Wessner, B., Ankersmit, H.J., Fuerst, W., Redl, H., Roth, E., Spittler, A. Shock (2006) [Pubmed]
  21. Immunonutrition. Singh, R., Gopalan, S., Sibal, A. Indian journal of pediatrics. (2002) [Pubmed]
  22. Traumatic atlanto-occipital dislocation with survival in children. Labbe, J.L., Leclair, O., Duparc, B. Journal of pediatric orthopaedics. Part B / European Paediatric Orthopaedic Society, Pediatric Orthopaedic Society of North America. (2001) [Pubmed]
  23. GFAP versus S100B in serum after traumatic brain injury: relationship to brain damage and outcome. Pelinka, L.E., Kroepfl, A., Leixnering, M., Buchinger, W., Raabe, A., Redl, H. J. Neurotrauma (2004) [Pubmed]
  24. Analysis of systemic interleukin-11 after major trauma. Schinkel, C., Wick, M., Muhr, G., Köller, M. Shock (2005) [Pubmed]
  25. Association between injury pattern of patients with multiple injuries and circulating levels of soluble tumor necrosis factor receptors, interleukin-6 and interleukin-10, and polymorphonuclear neutrophil elastase. Hensler, T., Sauerland, S., Bouillon, B., Raum, M., Rixen, D., Helling, H.J., Andermahr, J., Neugebauer, E.A. The Journal of trauma. (2002) [Pubmed]
  26. Serum S 100 B: a marker of brain damage in traumatic brain injury with and without multiple trauma. Pelinka, L.E., Toegel, E., Mauritz, W., Redl, H. Shock (2003) [Pubmed]
  27. Pulsatile nature of growth hormone levels in critically ill trauma victims. Melarvie, S., Jeevanandam, M., Holaday, N.J., Petersen, S.R. Surgery (1995) [Pubmed]
  28. Continuous intravenous infusion fentanyl for sedation and analgesia of the multiple trauma patient. Walsh, M., Smith, G.A., Yount, R.A., Ferlic, F.J., Wieschhaus, M.F. Annals of emergency medicine. (1991) [Pubmed]
  29. Influence of granulocyte-macrophage colony-stimulating factor (GM-CSF) on whole blood endotoxin responsiveness following trauma, cardiopulmonary bypass, and severe sepsis. Flohé, S., Börgermann, J., Domínguez, F.E., Majetschak, M., Lim, L., Kreuzfelder, E., Obertacke, U., Nast-Kolb, D., Schade, F.U. Shock (1999) [Pubmed]
  30. Response to pancuronium after loss of atracurium-induced neuromuscular blockade. Kelly, K.J., Clarens, D.M., Kohls, P.R., Nahum, A., Vance-Bryan, K. The Annals of pharmacotherapy. (1993) [Pubmed]
  31. Serum phospholipase A2 in patients with multiple injuries. Uhl, W., Büchler, M., Nevalainen, T.J., Deller, A., Beger, H.G. The Journal of trauma. (1990) [Pubmed]
  32. Strongly enhanced serum levels of vascular endothelial growth factor (VEGF) after polytrauma and burn. Grad, S., Ertel, W., Keel, M., Infanger, M., Vonderschmitt, D.J., Maly, F.E. Clin. Chem. Lab. Med. (1998) [Pubmed]
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