The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Croup


High impact information on Croup

  • A comparison of nebulized budesonide, intramuscular dexamethasone, and placebo for moderately severe croup [6].
  • CONCLUSIONS: In children with moderately severe croup, treatment with intramuscular dexamethasone or nebulized budesonide resulted in more rapid clinical improvement than did the administration of placebo, with dexamethasone offering the greatest improvement [6].
  • As compared with the placebo group, the children who received vitamin A recovered more rapidly from pneumonia (mean, 6.3 vs. 12.4 days, respectively; P less than 0.001) and diarrhea (mean, 5.6 vs. 8.5 days; P less than 0.001), had less croup (13 vs. 27 cases; P = 0.03), and spent fewer days in the hospital (mean, 10.6 vs. 14.8 days; P = 0.01) [7].
  • Many studies have attempted to find out whether steroid treatment is beneficial in children with croup, but the results have been inconclusive [8].
  • Placebo-controlled trial of prednisolone in children intubated for croup [8].

Chemical compound and disease context of Croup

  • We performed a prospective, blinded comparison of PP in children with croup versus healthy control subjects, analyzed the relationship between PP and Westley croup score (WCS), and observed the effect of racemic epinephrine (RE) on PP and WCS in a subgroup of patients with severe croup [9].
  • There was no consistent response to isoproterenol inhalation among those who had had croup and normal subjects [10].
  • In comparison to patients with upper respiratory illness alone, patients with croup had increased production of PV-specific IgE antibody, increased lymphoproliferative responses to PV antigen, and diminished histamine-induced suppression of lymphocyte transformation responses to PV [11].
  • Sevoflurane for intubation of an infant with croup [12].
  • Dexamethasone IM, or an equivalent dose of oral prednisone, may be considered in children with moderately severe croup who do not require hospitalization [13].

Biological context of Croup

  • In children with croup, single 2 or 4mg dosages of budesonide inhalation suspension were significantly more effective than placebo and as effective as oral dexamethasone 0.6 mg/kg or nebulised L-epinephrine (adrenaline) 4mg in alleviating croup symptoms and preventing or reducing the duration of hospitalisation [14].
  • The dexamethasone group had a lower frequency of stridor, Croup Score, and pulsus paradoxus measurement at 10 mins and at 6 and 12 hrs after extubation [15].
  • Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Nebulised epinephrine or corticosteroids in croup [16].

Gene context of Croup


Analytical, diagnostic and therapeutic context of Croup


  1. Acute bronchiolitis in tropical Africa: a hospital-based perspective in Ibadan, Nigeria. Johnson, A.W., Aderele, W.I., Osinusi, K., Gbadero, D.A., Fagbami, A.H., Rotowa, N.A. Pediatr. Pulmonol. (1996) [Pubmed]
  2. Bacterial tracheitis: report of eight new cases and review. Donnelly, B.W., McMillan, J.A., Weiner, L.B. Rev. Infect. Dis. (1990) [Pubmed]
  3. A randomized trial of a single dose of oral dexamethasone for mild croup. Bjornson, C.L., Klassen, T.P., Williamson, J., Brant, R., Mitton, C., Plint, A., Bulloch, B., Evered, L., Johnson, D.W. N. Engl. J. Med. (2004) [Pubmed]
  4. Antibiotics: their true place in the treatment of viral disease. Vance, J.C. Australian family physician. (1978) [Pubmed]
  5. Relationship between recurrent croup and airway hyperreactivity. Litmanovitch, M., Kivity, S., Soferman, R., Topilsky, M. Annals of allergy. (1990) [Pubmed]
  6. A comparison of nebulized budesonide, intramuscular dexamethasone, and placebo for moderately severe croup. Johnson, D.W., Jacobson, S., Edney, P.C., Hadfield, P., Mundy, M.E., Schuh, S. N. Engl. J. Med. (1998) [Pubmed]
  7. A randomized, controlled trial of vitamin A in children with severe measles. Hussey, G.D., Klein, M. N. Engl. J. Med. (1990) [Pubmed]
  8. Placebo-controlled trial of prednisolone in children intubated for croup. Tibballs, J., Shann, F.A., Landau, L.I. Lancet (1992) [Pubmed]
  9. Pulsus paradoxus: an objective measure of severity in croup. Steele, D.W., Santucci, K.A., Wright, R.O., Natarajan, R., McQuillen, K.K., Jay, G.D. Am. J. Respir. Crit. Care Med. (1998) [Pubmed]
  10. Pulmonary function in children with a history of laryngotracheobronchitis. Loughlin, G.M., Taussig, L.M. J. Pediatr. (1979) [Pubmed]
  11. Defective regulation of immune responses in croup due to parainfluenza virus. Welliver, R.C., Sun, M., Rinaldo, D. Pediatr. Res. (1985) [Pubmed]
  12. Sevoflurane for intubation of an infant with croup. Thurlow, J.A., Madden, A.P. British journal of anaesthesia. (1998) [Pubmed]
  13. Croup. Skolnik, N. The Journal of family practice. (1993) [Pubmed]
  14. Budesonide inhalation suspension: a review of its use in infants, children and adults with inflammatory respiratory disorders. Hvizdos, K.M., Jarvis, B. Drugs (2000) [Pubmed]
  15. Dexamethasone for the prevention of postextubation airway obstruction: a prospective, randomized, double-blind, placebo-controlled trial. Anene, O., Meert, K.L., Uy, H., Simpson, P., Sarnaik, A.P. Crit. Care Med. (1996) [Pubmed]
  16. Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Nebulised epinephrine or corticosteroids in croup. Ghosh, A., Morton, R. Emergency medicine journal : EMJ. (2001) [Pubmed]
  17. The indoor air and children's health study: methods and incidence rates. Marbury, M.C., Maldonado, G., Waller, L. Epidemiology (Cambridge, Mass.) (1996) [Pubmed]
  18. The incidence of gastroesophageal reflux in recurrent croup. Waki, E.Y., Madgy, D.N., Belenky, W.M., Gower, V.C. Int. J. Pediatr. Otorhinolaryngol. (1995) [Pubmed]
  19. Relation of two different subtypes of croup before age three to wheezing, atopy, and pulmonary function during childhood: a prospective study. Castro-Rodríguez, J.A., Holberg, C.J., Morgan, W.J., Wright, A.L., Halonen, M., Taussig, L.M., Martinez, F.D. Pediatrics (2001) [Pubmed]
  20. Pulmonary function and bronchial reactivity in children after croup. Gurwitz, D., Corey, M., Levison, H. Am. Rev. Respir. Dis. (1980) [Pubmed]
  21. Racemic epinephrine in the treatment of croup: nebulization alone versus nebulization with intermittent positive pressure breathing. Fogel, J.M., Berg, I.J., Gerber, M.A., Sherter, C.B. J. Pediatr. (1982) [Pubmed]
  22. Transcutaneous carbon dioxide pressure for monitoring patients with severe croup. Fanconi, S., Burger, R., Maurer, H., Uehlinger, J., Ghelfi, D., Mühlemann, C. J. Pediatr. (1990) [Pubmed]
  23. Outpatient treatment of croup with nebulized dexamethasone. Johnson, D.W., Schuh, S., Koren, G., Jaffee, D.M. Archives of pediatrics & adolescent medicine. (1996) [Pubmed]
  24. Intramuscular versus oral dexamethasone for the treatment of moderate-to-severe croup: a randomized, double-blind trial. Donaldson, D., Poleski, D., Knipple, E., Filips, K., Reetz, L., Pascual, R.G., Jackson, R.E. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine. (2003) [Pubmed]
  25. Oral dexamethasone in the treatment of croup: 0.15 mg/kg versus 0.3 mg/kg versus 0.6 mg/kg. Geelhoed, G.C., Macdonald, W.B. Pediatr. Pulmonol. (1995) [Pubmed]
WikiGenes - Universities