Disease relevance of Intermittent Positive-Pressure Breathing

• Corticosteroids and racemic epinephrine with IPPB in the treatment of croup [1].
• During CO2-induced hyperventilation, considerable differences in power of breathing were found between the two IPPB devices and the other two modes [2].
• The experiments were carried out to observe certain functional changes in the respiratory system which develop in the early stage of aspiration pneumonia and to study the possibility of influencing these changes by application of artificial ventilation (IPPB) and/or administration of dehydrobenzperidol [3].
• 11 patients with asthma and 3 with chronic bronchitis participated in a comparison, over 15 treatment periods, of the efficacy of 0.5 mg fenoterol and 5 mg of salbutamol, administered using intermittent positive pressure breathing [4].
• Pentobarbital-anesthetized greyhounds were passively hyperventilated using intermittent positive-pressure breathing (IPPV) and the effects of raised airway pressure, accompanied by hypocapnia and then by normocapnia, on liver blood flow and oxygen consumption were studied [5].

High impact information on Intermittent Positive-Pressure Breathing

• Albuterol is superior to isoproterenol as a bronchodilator when administered by IPPB because, for a given peak bronchodilation, cardiovascular side effects are fewer and bronchodilation persists longer with albuterol [6].
• The optimal dose of isoproterenol hydrochloride is 2.5 to 5.0 mg and the optimal dose of albuterol is 10 mg when these drugs are given by IPPB [6].
• A 37 year old man with pulmonary alveolar proteinosis and severe pulmonary physiologic impairment was treated empirically for 12 months with continuous oxygen, intermittent positive pressure breathing and aerosolized saline solution, heparin and acetylcysteine [7].
• Aerosol fenoterol by intermittent positive pressure breathing in asthmatic patients [8].
• Dose-response curves were compared for terbutaline from a metered-dose aerosol, and pressure nebulized with and without intermittent positive pressure breathing (IPPB) [9].

Chemical compound and disease context of Intermittent Positive-Pressure Breathing

• Use of racemic epinephrine hydrochloride (Vaponefrin), delivered by intermittent positive-pressure breathing, in the treatment of laryngotracheobronchitis (croup) produced acute beneficial results in a controlled study [10].

Biological context of Intermittent Positive-Pressure Breathing

• 5 mg salbutamol nebulized with IPPB resulted in a significant increase in peak expiratory flow rate when given before or after either Rotacaps or salbutamol nebulized without IPPB, whereas neither the dry powder nor the nebulized drug without IPPB resulted in significant change when given after salbutamol nebulized with IPPB [11].
• It was concluded that the use of IPPB to administer nebulized salbutamol in oxygen had no advantage over passive inhalation in the initial treatment of patients with severe acute asthma [12].

Associations of Intermittent Positive-Pressure Breathing with chemical compounds

• Studies were performed on the 14 patients, each of whom was randomly assigned to one of two treatment groups: distilled water or racemic epinephrine (RE), both being nebulized and delivered by manual IPPB [13].
• Double-blind comparison of metaproterenol and isoetharine-phenylephrine solutions in intermittent positive pressure breathing in bronchospastic conditions [14].
• Aerosolized lidocaine, administered by IPPB, is a safe and effective topical anesthetic agent which may be useful for instrumentation of the upper airway [15].
• Five minutes after IPPB, Pao2 decreased to 69.2 +/- 8 torr; alveolar-arterial Po2 difference, breathing 21% O2, increased significantly; and serum K+ concentration decreased significantly [16].
• Serum levels were measured in 13 subjects who received gentamicin either by inspiratory intermittent positive pressure breathing (IPPB-I) or by tracheal instillation [17].

Gene context of Intermittent Positive-Pressure Breathing

• Previous trials with aerosols given by intermittent positive-pressure breathing were unrewarding, but BiPAP is unique in that inspiratory (IPAP) and expiratory (EPAP) support pressures may be set separately [18].
• The physiology of mechanical ventilation and the mechanical zoo: IPPB, PEEP, CPAP [19].
• A beta2-receptor agonist, terbutaline (Bricanyl), in doses of 2.5 and 5 mg was inhaled by IPPB with a Bird Mark 8 in a double-blind cross-over randomized study on consecutive days in 12 patients with at least 15% reversibility of PEFR or FEV 1 [20].

Analytical, diagnostic and therapeutic context of Intermittent Positive-Pressure Breathing

• Predictors of patient adherence to long-term home nebulizer therapy for COPD. The IPPB Study Group. Intermittent Positive Pressure Breathing [21].
• OBJECTIVE: We investigated the clinical response to equivalent doses of salbutamol delivered, via metered dose inhaler (MDI) during non-invasive mechanical ventilation (NIMV-MDI), during spontaneous breathing using a spacer (MDI-Spacer), and also during intermittent positive pressure breathing (IPPB) [22].
• The effects of five different doses of a 5% inhalant solution of metaproterenol on pulmonary function were compared in a placebo-controlled double-blind cross-over study in 40 asthmatic patients who received the drug via intermittent positive pressure breathing (IPPB) [23].
• It is concluded that salbutamol given by IPPB is better than that given by slow intravenous injection in severe acute asthma [24].

References