Disease relevance of Cheirogaleidae

• To assess the effect of aging and accelerated aging on the circadian pacemaker of this primate, we measured body weight variations, the daily rhythm in urine 6-sulfatoxymelatonin and the light-induced expression of the immediate early gene (Fos) in the suprachiasmatic nucleus of mouse lemurs that had been exposed to different photoperiodic cycles [1].

Psychiatry related information on Cheirogaleidae

• The role of olfaction/olfactory cues on photoperiodic responses was assessed in Malagasy primate, the gray mouse lemur [2].
• Mouse lemurs remained torpid between 1.7-8.9 h with a daily mean of 3.4 h, and their Tsk s fell to a minimum of 18.8 degrees C. Mean home ranges of mouse lemurs which remained normothermic were similar in the rainy and dry season [3].

High impact information on Cheirogaleidae

• We apply the likelihood models to analyze two mitochondrial protein-coding genes, cytochrome oxidase II and cytochrome b, to estimate divergence times of Malagasy mouse lemurs and related outgroups [4].
• Binding sites for these proteins also occur near the CCAAT box of other embryonically expressed genes, including rabbit, mouse, and dwarf lemur gamma genes and the human epsilon globin gene [5].
• Immunohistochemical analysis of cerebral cortical and vascular lesions in the primate Microcebus murinus reveal distinct amyloid beta1-42 and beta1-40 immunoreactivity profiles [6].
• The nature of the Abeta species in Microcebus murinus brain was investigated immunocytochemically using polyclonal antibodies with clear specificity for the Abeta42 and Abeta40 C-termini [6].
• We assessed cerebral atrophy in mouse lemur primates (Microcebus murinus) by estimating CSF volume in their brains from 4.7 Tesla T2-weighted magnetic resonance images [7].

Biological context of Cheirogaleidae

• Artificially accelerated aging by shortened photoperiod alters early gene expression (Fos) in the suprachiasmatic nucleus and sulfatoxymelatonin excretion in a small primate, Microcebus murinus [1].
• Relationship between urinary estrogen levels before conception and sex ratio at birth in a primate, the gray mouse lemur [8].
• Taste thresholds and suprathreshold responses to tannin-rich plant extracts and quinine in a primate species (Microcebus murinus) [9].
• Seasonal variation of taste threshold for sucrose in a prosimian species, Microcebus murinus [10].

Anatomical context of Cheirogaleidae

• Fos expression following exposure to low levels of irradiance was reduced by 88% in the suprachiasmatic nucleus of aged mouse lemurs [1].
• Given the functional importance of the cholinergic modulation of endocannabinoid signaling, here we studied CB1 cannabinoid receptor distribution in cholinergic basal forebrain territories and their cortical projection areas in a prosimian primate, the gray mouse lemur [11].

Associations of Cheirogaleidae with chemical compounds

• The classical pattern of 6-sulfatoxymelatonin excretion was significantly altered in aged mouse lemurs which failed to show a nocturnal peak [1].
• In 6 isolated adult male lesser mouse lemurs, concentrations of testosterone in plasma were determinated at 6-h intervals over a 24-h period [12].
• Effects of long-term grouping on serum cortisol levels in Microcebus murinus (Prosimii) [13].
• In mouse lemur, DHEA-S met the criteria for a biomarker of aging [14].
• Social influences on oestrous cycle length and plasma progesterone concentrations in the female lesser mouse lemur (Microcebus murinus) [15].

Gene context of Cheirogaleidae

• Cloning of the presenilin 2 cDNA and its distribution in brain of the primate, Microcebus murinus: coexpression with betaAPP and Tau proteins [16].
• Furthermore, the present data indicate that A beta deposition in mouse lemurs is not age dependent, but occurs in a few vulnerable old animals [17].
• beta-Amyloid protein precursor in Microcebus murinus: genotyping and brain localization [18].
• Molecular cloning, sequencing, and brain expression of the presenilin 1 gene in Microcebus murinus [19].
• In all haplorhine species, horizontal cells are densely labeled with parvalbumin whereas in mouse lemur horizontal cells express calbindin but not parvalbumin [20].

References