The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Video Games

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Video Games

  • In this study, able-bodied individuals and people with high-level spinal injury used the LF-ASD brain switch to control a video game in real time [1].
  • CONCLUSION: Playing video games enhanced allergic responses with a concomitant increased release of substance P, vasoactive intestinal peptide and nerve growth factor, and skewing of the cytokine pattern toward Th2 type in the patients with atopic eczema/dermatitis syndrome [2].
  • We assessed blood pressure responses of a multiethnic (Black and White) sample of 120 children of hypertensive families to orthostasis, video game, forehead cold, and dynamic exercise, and monitored the children's ambulatory pressure 24 hours later [3].
  • Systemically infused tritiated norepinephrine (NE) was used to estimate total body NE spillover into arterial blood during mental challenge (playing a video game) in 18 young (mean age 35 years old) patients with essential hypertension and 20 normotensives of similar age [4].

Psychiatry related information on Video Games


High impact information on Video Games

  • Evidence for striatal dopamine release during a video game [6].
  • Binding of raclopride to dopamine receptors in the striatum was significantly reduced during the video game compared with baseline levels of binding, consistent with increased release and binding of dopamine to its receptors [6].
  • Hazard of video games in patients with light-sensitive epilepsy [7].
  • The amplitude of a frontal midline theta (6-7 Hz) signal increased with video-game play relative to the watching and eyes open resting conditions [8].
  • At baseline, the 24-hour urinary potassium/creatinine ratio varied inversely with diastolic CVR to the video game stressor in white children (r = -0.55, p = 0.02) [9].

Biological context of Video Games


Associations of Video Games with chemical compounds

  • This study compared the cardiovascular increases due to a video game stress task plus 1.0 mg nicotine with those of stress or nicotine alone using an aerosol method of presenting nicotine in measured doses [11].
  • No significant changes were found from baseline to after video game play for lactate (18.2% increase; P = .07) and glucose (0.9% decrease; P = .59) levels [12].
  • Six patients with CAD then received intracoronary phentolamine (1.7 micrograms/kg/min for 5 minutes, followed by 0.17 micrograms/kg/min) and played the video game again [13].
  • We thus examined the effect of built-in music on cortisol secretion as a consequence of video game playing [14].
  • They were recommended to avoid playing video-games, but sodium valproate was effective if seizures persisted even after such avoidance [15].

Gene context of Video Games

  • Five other patients (4 with CAD, 1 with NCA) repeated the video game during intracoronary administration of 5% dextrose, with systemic and coronary hemodynamic and noradrenergic responses unchanged from those during the initial video game.(ABSTRACT TRUNCATED AT 250 WORDS)[13]
  • RESULTS: Playing video games had no effect on the normal subjects or the patients with allergic rhinitis [2].
  • We report here the development of Spatial-Temporal Math Video Game software designed to teach fractions and proportional math, and its strikingly successful use in a study involving 237 second-grade children (age range six years eight months-eight years five months) [16].
  • On day 1, each student played three commercially available video games (Top Spin, XSN Sports; Project Gotham Racing 2, Bizarre Creations; and Amped 2, XSN Sports) for 30 minutes on an X-box (Microsoft, Seattle, WA) and was judged both objectively and subjectively [17].
  • Previous exposure to the Mental Rotation Test, American College Test scores and frequent computer or video game play predicted performance on the test [18].

Analytical, diagnostic and therapeutic context of Video Games

  • Diagnosing video game epilepsy requires performing an EEG with IPS and pattern stimulation [19].
  • Basal blood pressure values were measured according to the NIH Task Force. With baseline measures and body mass index controlled for, analysis of covariance showed that the video game provoked significant and incremental cardiovascular reactivity across the games in adolescents when compared with the two other groups of children [20].


  1. Real-time control of a video game with a direct brain--computer interface. Mason, S.G., Bohringer, R., Borisoff, J.F., Birch, G.E. Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society. (2004) [Pubmed]
  2. Enhancement of allergic skin wheal responses in patients with atopic eczema/dermatitis syndrome by playing video games or by a frequently ringing mobile phone. Kimata, H. Eur. J. Clin. Invest. (2003) [Pubmed]
  3. Pressor reactivity, ethnicity, and 24-hour ambulatory monitoring in children from hypertensive families. Treiber, F.A., Murphy, J.K., Davis, H., Raunikar, R.A., Pflieger, K., Strong, W.B. Behavioral medicine (Washington, D.C.) (1994) [Pubmed]
  4. Pharmacologic and tracer methods to study sympathetic function in primary hypertension. Goldstein, D.S., Eisenhofer, G., Garty, M., Sax, F.L., Keiser, H.R., Kopin, I.J. Clinical and experimental hypertension. Part A, Theory and practice. (1989) [Pubmed]
  5. Cardiovascular responses in type A and type B men to a series of stressors. Ward, M.M., Chesney, M.A., Swan, G.E., Black, G.W., Parker, S.D., Rosenman, R.H. Journal of behavioral medicine. (1986) [Pubmed]
  6. Evidence for striatal dopamine release during a video game. Koepp, M.J., Gunn, R.N., Lawrence, A.D., Cunningham, V.J., Dagher, A., Jones, T., Brooks, D.J., Bench, C.J., Grasby, P.M. Nature (1998) [Pubmed]
  7. Hazard of video games in patients with light-sensitive epilepsy. Dahlquist, N.R., Mellinger, J.F., Klass, D.W. JAMA (1983) [Pubmed]
  8. Mental effort-related EEG modulation during video-game play: comparison between juvenile subjects with epilepsy and normal control subjects. Pellouchoud, E., Smith, M.E., McEvoy, L., Gevins, A. Epilepsia (1999) [Pubmed]
  9. Potassium intake and cardiovascular reactivity in children with risk factors for essential hypertension. Sorof, J.M., Forman, A., Cole, N., Jemerin, J.M., Morris, R.C. J. Pediatr. (1997) [Pubmed]
  10. Plasma norepinephrine pharmacokinetics during mental challenge. Goldstein, D.S., Eisenhofer, G., Sax, F.L., Keiser, H.R., Kopin, I.J. Psychosomatic medicine. (1987) [Pubmed]
  11. The cardiovascular effects of nicotine during stress. Perkins, K.A., Epstein, L.H., Jennings, J.R., Stiller, R. Psychopharmacology (Berl.) (1986) [Pubmed]
  12. Metabolic and physiologic responses to video game play in 7- to 10-year-old boys. Wang, X., Perry, A.C. Archives of pediatrics & adolescent medicine. (2006) [Pubmed]
  13. Sympathetically mediated effects of mental stress on the cardiac microcirculation of patients with coronary artery disease. Dakak, N., Quyyumi, A.A., Eisenhofer, G., Goldstein, D.S., Cannon, R.O. Am. J. Cardiol. (1995) [Pubmed]
  14. Physiological stress response to video-game playing: the contribution of built-in music. Hébert, S., Béland, R., Dionne-Fournelle, O., Crête, M., Lupien, S.J. Life Sci. (2005) [Pubmed]
  15. Electroclinical study of video-game epilepsy. Maeda, Y., Kurokawa, T., Sakamoto, K., Kitamoto, I., Ueda, K., Tashima, S. Developmental medicine and child neurology. (1990) [Pubmed]
  16. Enhanced learning of proportional math through music training and spatial-temporal training. Graziano, A.B., Peterson, M., Shaw, G.L. Neurol. Res. (1999) [Pubmed]
  17. Can video games be used to predict or improve laparoscopic skills? Rosenberg, B.H., Landsittel, D., Averch, T.D. J. Endourol. (2005) [Pubmed]
  18. Role of strategies and prior exposure in mental rotation. Cherney, I.D., Neff, N.L. Perceptual and motor skills. (2004) [Pubmed]
  19. Video material and epilepsy. Harding, G.F., Jeavons, P.M., Edson, A.S. Epilepsia (1994) [Pubmed]
  20. Changes in blood pressure reactivity and 24-hour blood pressure profile occurring at puberty. Modesti, P.A., Pela, I., Cecioni, I., Gensini, G.F., Serneri, G.G., Bartolozzi, G. Angiology. (1994) [Pubmed]
WikiGenes - Universities