Disease relevance of Video Games

• In this study, able-bodied individuals and people with high-level spinal injury used the LF-ASD brain switch to control a video game in real time [1].
• CONCLUSION: Playing video games enhanced allergic responses with a concomitant increased release of substance P, vasoactive intestinal peptide and nerve growth factor, and skewing of the cytokine pattern toward Th2 type in the patients with atopic eczema/dermatitis syndrome [2].
• We assessed blood pressure responses of a multiethnic (Black and White) sample of 120 children of hypertensive families to orthostasis, video game, forehead cold, and dynamic exercise, and monitored the children's ambulatory pressure 24 hours later [3].
• Systemically infused tritiated norepinephrine (NE) was used to estimate total body NE spillover into arterial blood during mental challenge (playing a video game) in 18 young (mean age 35 years old) patients with essential hypertension and 20 normotensives of similar age [4].

Psychiatry related information on Video Games

• They were monitored for systolic (SBP) and diastolic blood pressure (DBP) and heart rate (HR) responses during a series of six challenging tasks: Mental Arithmetic, Hypothesis Testing, Reaction Time, Video Game, Handgrip, and Cold Pressor [5].

High impact information on Video Games

• Evidence for striatal dopamine release during a video game [6].
• Binding of raclopride to dopamine receptors in the striatum was significantly reduced during the video game compared with baseline levels of binding, consistent with increased release and binding of dopamine to its receptors [6].
• Hazard of video games in patients with light-sensitive epilepsy [7].
• The amplitude of a frontal midline theta (6-7 Hz) signal increased with video-game play relative to the watching and eyes open resting conditions [8].
• At baseline, the 24-hour urinary potassium/creatinine ratio varied inversely with diastolic CVR to the video game stressor in white children (r = -0.55, p = 0.02) [9].

Biological context of Video Games

• We simultaneously infused tracer-labeled norepinephrine (NE) and isoproterenol (ISO) intravenously into 14 subjects to measure forearm and total body NE pharmacokinetics at rest and in response to mental challenge (video game or cognitive task) [10].

Associations of Video Games with chemical compounds

• This study compared the cardiovascular increases due to a video game stress task plus 1.0 mg nicotine with those of stress or nicotine alone using an aerosol method of presenting nicotine in measured doses [11].
• No significant changes were found from baseline to after video game play for lactate (18.2% increase; P = .07) and glucose (0.9% decrease; P = .59) levels [12].
• Six patients with CAD then received intracoronary phentolamine (1.7 micrograms/kg/min for 5 minutes, followed by 0.17 micrograms/kg/min) and played the video game again [13].
• We thus examined the effect of built-in music on cortisol secretion as a consequence of video game playing [14].
• They were recommended to avoid playing video-games, but sodium valproate was effective if seizures persisted even after such avoidance [15].

Gene context of Video Games

• Five other patients (4 with CAD, 1 with NCA) repeated the video game during intracoronary administration of 5% dextrose, with systemic and coronary hemodynamic and noradrenergic responses unchanged from those during the initial video game.(ABSTRACT TRUNCATED AT 250 WORDS)[13]
• RESULTS: Playing video games had no effect on the normal subjects or the patients with allergic rhinitis [2].
• We report here the development of Spatial-Temporal Math Video Game software designed to teach fractions and proportional math, and its strikingly successful use in a study involving 237 second-grade children (age range six years eight months-eight years five months) [16].
• On day 1, each student played three commercially available video games (Top Spin, XSN Sports; Project Gotham Racing 2, Bizarre Creations; and Amped 2, XSN Sports) for 30 minutes on an X-box (Microsoft, Seattle, WA) and was judged both objectively and subjectively [17].
• Previous exposure to the Mental Rotation Test, American College Test scores and frequent computer or video game play predicted performance on the test [18].

Analytical, diagnostic and therapeutic context of Video Games

• Diagnosing video game epilepsy requires performing an EEG with IPS and pattern stimulation [19].
• Basal blood pressure values were measured according to the NIH Task Force. With baseline measures and body mass index controlled for, analysis of covariance showed that the video game provoked significant and incremental cardiovascular reactivity across the games in adolescents when compared with the two other groups of children [20].

References