The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Spinal Injuries

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Spinal Injuries


Psychiatry related information on Spinal Injuries

  • PARTICIPANTS: Nine men with T5 to T12 paraplegia, 8 of whom had complete lesions and 1 with some sacral sparing (American Spinal Injury Association grade B) without proprioception, matched to 9 able-bodied men [6].

High impact information on Spinal Injuries


Chemical compound and disease context of Spinal Injuries


Biological context of Spinal Injuries

  • Since upregulation alone of CGRP would occur in an acute temporal window (by 2 to 3 days following spinal injury), these results are interpreted to be invasion of laminae III and IV by sprouting of CGRP containing fine primary afferents [16].
  • Because noradrenergic receptors proliferate after spinal injury and descending noradrenergic pathways contribute to regulation of bladder control, we examined the effects of administering an alpha-1A-adrenergic antagonist, Tamsulosin, on urodynamics [17].
  • Effects of TRH and high-dose corticosteroid therapy on evoked potentials, and tissue Na+,K+ and water content in experimental spinal injury [18].

Anatomical context of Spinal Injuries

  • We examined whether fibroblasts, genetically modified to express BDNF and NT-3 (Fb-BDNF/NT3) and transplanted into a thoracic spinal injury site, would enhance recovery of bladder function and whether this treatment would be associated with reorganization of lumbosacral spinal circuits implicated in bladder function [19].
  • STUDY DESIGN: Acute respiratory compromise is occasionally observed in a subgroup of patients with upper spinal injuries involving the C2 vertebrae [20].
  • CONCLUSION: Twenty microlitres of intrathecal bupivacaine before or after acute photochemical spinal injury improves hindlimb motor recovery and SEP parameters in rats [21].
  • Our report describes the course of a 70-year-old man with C5 American Spinal Injury Association class A tetraplegia who developed a perforated cecum secondary to Crohn's disease [22].
  • Serial measurement of CRP in patients with spinal injury may help distinguish between urinary tract colonisation and infection and be useful in monitoring the response to the treatment of clinical UTI [23].

Gene context of Spinal Injuries

  • VEGF is a key mediator of the angiogenic response to cerebral and peripheral ischaemia, and promotes nerve repair following traumatic spinal injury [24].
  • These results demonstrate that NT-3 may be of benefit in preventing the secondary cell loss that occurs following spinal injury [25].
  • The nursing management of MRSA on a spinal injuries unit [26].
  • We measured immunoglobulins in the sera of 33 patients on days 1, 3, 6, 10, and 17 and three to four weeks after surgical operations (mostly hysterectomy or appendectomy) or (six patients) after spinal injury [27].
  • Combined treatment with neurotrophin-3 and LSD facilitates behavioral recovery from double-hemisection spinal injury in neonatal rats [28].

Analytical, diagnostic and therapeutic context of Spinal Injuries


  1. Trauma and multiple sclerosis: a population-based cohort study from Olmsted County, Minnesota. Siva, A., Radhakrishnan, K., Kurland, L.T., O'Brien, P.C., Swanson, J.W., Rodriguez, M. Neurology (1993) [Pubmed]
  2. Glutamate- and GABA-immunoreactive synapses on sympathetic preganglionic neurons caudal to a spinal cord transection in rats. Llewellyn-Smith, I.J., Cassam, A.K., Krenz, N.R., Krassioukov, A.V., Weaver, L.C. Neuroscience (1997) [Pubmed]
  3. Effect of high-dose corticosteroid therapy on blood flow, evoked potentials, and extracellular calcium in experimental spinal injury. Young, W., Flamm, E.S. J. Neurosurg. (1982) [Pubmed]
  4. Shoulder mass and pain in a patient with C5 American spinal injury association grade a tetraplegia. Bruel, B.M., Dajoyag-Mejia, M.A. American journal of physical medicine & rehabilitation / Association of Academic Physiatrists. (2005) [Pubmed]
  5. Baclofen reduces tone-evoked activity of cochlear nucleus neurons. Caspary, D.M., Rybak, L.P., Faingold, C.L. Hear. Res. (1984) [Pubmed]
  6. Postural control during stance in paraplegia: effects of medially linked versus unlinked knee-ankle-foot orthoses. Middleton, J.W., Sinclair, P.J., Smith, R.M., Davis, G.M. Archives of physical medicine and rehabilitation. (1999) [Pubmed]
  7. Thyrotropin-releasing hormone improves neurologic recovery after spinal trauma in cats. Faden, A.I., Jacobs, T.P., Holaday, J.W. N. Engl. J. Med. (1981) [Pubmed]
  8. Transgenic inhibition of Nogo-66 receptor function allows axonal sprouting and improved locomotion after spinal injury. Li, S., Kim, J.E., Budel, S., Hampton, T.G., Strittmatter, S.M. Mol. Cell. Neurosci. (2005) [Pubmed]
  9. Comparison of thyrotropin-releasing hormone (TRH), naloxone, and dexamethasone treatments in experimental spinal injury. Faden, A.I., Jacobs, T.P., Smith, M.T., Holaday, J.W. Neurology (1983) [Pubmed]
  10. Tizanidine. A review of its pharmacology, clinical efficacy and tolerability in the management of spasticity associated with cerebral and spinal disorders. Wagstaff, A.J., Bryson, H.M. Drugs (1997) [Pubmed]
  11. Positive and negative contrast myelography in spinal trauma. Pay, N.T., George, A.E., Benjamin, V., Bergeron, T., Lin, J.P., Kricheff, I.I. Radiology. (1977) [Pubmed]
  12. Effect of flunarizine and methylprednisolone on functional recovery after experimental spinal injury. De Ley, G., Leybaert, L. J. Neurotrauma (1993) [Pubmed]
  13. Induction of VEGF and VEGF receptors in the spinal cord after mechanical spinal injury and prostaglandin administration. Sköld, M., Cullheim, S., Hammarberg, H., Piehl, F., Suneson, A., Lake, S., Sjögren, A., Walum, E., Risling, M. Eur. J. Neurosci. (2000) [Pubmed]
  14. Characteristics of the electrical oscillations evoked by 4-aminopyridine on dorsal root fibers and their relation to fictive locomotor patterns in the rat spinal cord in vitro. Taccola, G., Nistri, A. Neuroscience (2005) [Pubmed]
  15. Intraspinal injection of adenosine agonists protect against L-NAME induced neuronal loss in the rat. Dora, C.D., Koch, S., Sanchez, A., Ruenes, G., Liu, S., Yezierski, R.P. J. Neurotrauma (1998) [Pubmed]
  16. Spinal cord injury and anti-NGF treatment results in changes in CGRP density and distribution in the dorsal horn in the rat. Christensen, M.D., Hulsebosch, C.E. Exp. Neurol. (1997) [Pubmed]
  17. Transplantation of neuronal and glial restricted precursors into contused spinal cord improves bladder and motor functions, decreases thermal hypersensitivity, and modifies intraspinal circuitry. Mitsui, T., Shumsky, J.S., Lepore, A.C., Murray, M., Fischer, I. J. Neurosci. (2005) [Pubmed]
  18. Effects of TRH and high-dose corticosteroid therapy on evoked potentials, and tissue Na+,K+ and water content in experimental spinal injury. Akdemir, H., Paşaoğlu, H., Arman, F., Coksevim, B., Paşaoğlu, A. Research in experimental medicine. Zeitschrift für die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie. (1993) [Pubmed]
  19. Transplants of fibroblasts expressing BDNF and NT-3 promote recovery of bladder and hindlimb function following spinal contusion injury in rats. Mitsui, T., Fischer, I., Shumsky, J.S., Murray, M. Exp. Neurol. (2005) [Pubmed]
  20. Acute respiratory compromise associated with flexed cervical traction after C2 fractures. Harrop, J.S., Vaccaro, A., Przybylski, G.J. Spine. (2001) [Pubmed]
  21. Intrathecal bupivacaine protects against extension of lesions in an acute photochemical spinal cord injury model. Lopez, S., Privat, A., Bernard, N., Ohanna, F., Vergnes, C., Capdevila, X. Canadian journal of anaesthesia = Journal canadien d'anesthésie. (2004) [Pubmed]
  22. Crohn's disease in a patient with acute spinal cord injury: a case report of diagnostic challenges in the rehabilitation setting. Yung, J.C., Groah, S.L. Archives of physical medicine and rehabilitation. (2001) [Pubmed]
  23. Serial concentrations of C-reactive protein as an indicator of urinary tract infection in patients with spinal injury. Galloway, A., Green, H.T., Windsor, J.J., Menon, K.K., Gardner, B.P., Krishnan, K.R. J. Clin. Pathol. (1986) [Pubmed]
  24. Neuroprotective role of vascular endothelial growth factor: signalling mechanisms, biological function, and therapeutic potential. Zachary, I. Neurosignals (2005) [Pubmed]
  25. NT-3, but not BDNF, prevents atrophy and death of axotomized spinal cord projection neurons. Bradbury, E.J., King, V.R., Simmons, L.J., Priestley, J.V., McMahon, S.B. Eur. J. Neurosci. (1998) [Pubmed]
  26. The nursing management of MRSA on a spinal injuries unit. Tyler, C. British journal of nursing (Mark Allen Publishing) (1997) [Pubmed]
  27. Serum immunoglobulins after surgical operation. Fuller, J.M., Keyser, J.W. Clin. Chem. (1975) [Pubmed]
  28. Combined treatment with neurotrophin-3 and LSD facilitates behavioral recovery from double-hemisection spinal injury in neonatal rats. Arvanian, V.L., Manuzon, H., Davenport, M., Bushell, G., Mendell, L.M., Robinson, J.K. J. Neurotrauma (2006) [Pubmed]
  29. A new instrument for outcome assessment in rehabilitation medicine: Spinal cord injury ability realization measurement index. Catz, A., Greenberg, E., Itzkovich, M., Bluvshtein, V., Ronen, J., Gelernter, I. Archives of physical medicine and rehabilitation. (2004) [Pubmed]
  30. The effect of residual neurological deficit on oral glucose tolerance in persons with chronic spinal cord injury. Bauman, W.A., Adkins, R.H., Spungen, A.M., Waters, R.L. Spinal Cord (1999) [Pubmed]
  31. Tendon transfers and functional electrical stimulation for restoration of hand function in spinal cord injury. Keith, M.W., Kilgore, K.L., Peckham, P.H., Wuolle, K.S., Creasey, G., Lemay, M. The Journal of hand surgery. (1996) [Pubmed]
  32. Post-traumatic myelopathy following flopping high jump: a pilot case of spinal manipulation. Woo, C.C. Journal of manipulative and physiological therapeutics. (1993) [Pubmed]
WikiGenes - Universities