Disease relevance of Pancreatitis, Alcoholic

• Failure to produce experimental alcoholic pancreatitis suggests that ethanol may only increase predisposition to pancreatitis [1].
• Bile salt malabsorption in pancreatic insufficiency secondary to alcoholic pancreatitis [2].
• It is concluded that: (1) cimetidine is not superior to a placebo in the management of mild to moderately severe acute alcoholic pancreatitis and (2) serum amylase activity in patients with acute alcoholic pancreatitis given cimetidine tends to be greater and hyperamylasemia is of somewhat longer duration than in those treated with a placebo [3].
• Heterozygotes c1/c2 were present only in patients consuming excessive amounts of ethanol; in 7% of patients with alcoholic cirrhosis and in 4.5% of those with chronic alcoholic pancreatitis [4].
• AIM: To assess the effectiveness of and complications associated with polyvinyl alcohol (PVA) and gelatin sponge particles embolization of splenic artery pseudoaneurysm complicating chronic alcoholic pancreatitis [5].

High impact information on Pancreatitis, Alcoholic

• Gastric lipase in alcoholic pancreatitis. Comparison of secretive profiles following pentagastrin stimulation in normal adults and patients with pancreatic insufficiency [6].
• Duct obstruction with an acrylate glue for treatment of chronic alcoholic pancreatitis [7].
• Failure of glucagon in the treatment of alcoholic pancreatitis [8].
• Screening for mutations of the cationic trypsinogen gene: are they of relevance in chronic alcoholic pancreatitis [9]?
• The role of acetaldehyde in the pathogenesis of acute alcoholic pancreatitis [10].

Chemical compound and disease context of Pancreatitis, Alcoholic

• Acetaminophen hepatotoxicity associated with alcoholic pancreatitis [11].
• Kinetics of [24-14C] cholic acid and [24-14C] chenodeoxycholic acid and biliary lipid composition were determined in patients with chronic alcoholic pancreatitis with (n = 8) and without (n = 8) steatorrhoea [12].
• CONCLUSIONS: Two simple admission laboratory values--white blood cell count and serum glucose level--are useful predictors for development of major systemic complications and/or mortality in patients with first-time alcoholic pancreatitis [13].
• A prior study demonstrated that 41 percent of the patients presenting to our hospital with alcoholic pancreatitis had serum triglyceride elevations [14].
• In this model simulating acute alcoholic pancreatitis, both the early physiologic injury response and the early morphologic changes are mediated at least in part by free radicals, which are generated by xanthine oxidase converted reversibly from xanthine dehydrogenase [15].

Biological context of Pancreatitis, Alcoholic

• Alpha 1 antitrypsin phenotypes, with particular regard to alcoholic pancreatitis, were studied [16].
• As for the ADH 2 genotype, distribution of 2(1)/2(1), 2(1)/2(2), and 2(2)/2(2) was 35%, 30%, and 35% in alcoholics with normal pancreatic function; 4%, 39%, and 57% in the chronic alcoholic pancreatitis group; and 0%, 50%, and 50% in the chronic nonalcoholic pancreatitis group, respectively [17].

Anatomical context of Pancreatitis, Alcoholic

• BACKGROUND: The pathogenesis of alcoholic pancreatitis may involve the metabolism of ethanol (via oxidative and non-oxidative pathways) within the pancreas [18].

Gene context of Pancreatitis, Alcoholic

• RESULTS: BRCA1 expression was down-regulated in chronic alcoholic pancreatitis, in particular on the RNA level [19].
• This study shows that SPINK1 N34S and CFTR Q1352H mutations are uncommon and do not play an important role in chronic alcoholic pancreatitis in Korea [20].
• CONCLUSION: The results classify E32del mesotrypsinogen as a frequent polymorphic variant, which is not associated with chronic alcoholic pancreatitis [21].
• The aim of this study was to investigate if this and other polymorphisms, at position -1019 [C(-1019)T], 4808 [G(4808)A], and 7668 [T(7668)A] of the CYP2E1 gene are associated with alcoholic pancreatitis [22].
• The pancreatitis-associated protein in hereditary and chronic alcoholic pancreatitis [23].

Analytical, diagnostic and therapeutic context of Pancreatitis, Alcoholic

• Oral cholecystography in the early phase of acute alcoholic pancreatitis. A prospective, randomized comparison of Telepaque and Bilopaque [24].
• Disappearance of a large mediastinal pseudocyst in a patient with chronic alcoholic pancreatitis after total parenteral nutrition [25].
• RESULTS: In patients with chronic alcoholic pancreatitis, particularly in those with advanced pancreatic structural damage in imaging techniques, fasting plasma amylin levels were significantly higher (p < 0.01) than in controls [26].

References