Gene Review:
IAPP - islet amyloid polypeptide
Homo sapiens
Synonyms:
AMYLIN, Amylin, DAP, Diabetes-associated peptide, IAP, ...
- Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells. Westermark, P., Wernstedt, C., Wilander, E., Hayden, D.W., O'Brien, T.D., Johnson, K.H. Proc. Natl. Acad. Sci. U.S.A. (1987)
- Amyloidogenicity and cytotoxicity of recombinant mature human islet amyloid polypeptide (rhIAPP). Lopes, D.H., Colin, C., Degaki, T.L., de Sousa, A.C., Vieira, M.N., Sebollela, A., Martinez, A.M., Bloch, C., Ferreira, S.T., Sogayar, M.C. J. Biol. Chem. (2004)
- Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes. Kahn, S.E., Andrikopoulos, S., Verchere, C.B. Diabetes (1999)
- Estrogen can prevent or reverse obesity and diabetes in mice expressing human islet amyloid polypeptide. Geisler, J.G., Zawalich, W., Zawalich, K., Lakey, J.R., Stukenbrok, H., Milici, A.J., Soeller, W.C. Diabetes (2002)
- Activation of peroxisome proliferator-activated receptor-gamma by rosiglitazone protects human islet cells against human islet amyloid polypeptide toxicity by a phosphatidylinositol 3'-kinase-dependent pathway. Lin, C.Y., Gurlo, T., Haataja, L., Hsueh, W.A., Butler, P.C. J. Clin. Endocrinol. Metab. (2005)
- Amylin and hypertension: association of an amylin -G132A gene mutation and hypertension in humans and amylin-induced endothelium dysfunction in rats. Novials, A., Rodriguez-Mañas, L., Chico, A., El Assar, M., Casas, S., Gomis, R. J. Clin. Endocrinol. Metab. (2007)
- Protofibrillar islet amyloid polypeptide permeabilizes synthetic vesicles by a pore-like mechanism that may be relevant to type II diabetes. Anguiano, M., Nowak, R.J., Lansbury, P.T. Biochemistry (2002)
- Recovery and purification of highly aggregation-prone disulfide-containing peptides: application to islet amyloid polypeptide. Abedini, A., Singh, G., Raleigh, D.P. Anal. Biochem. (2006)
- Anorexia following the intrahypothalamic administration of amylin. Chance, W.T., Balasubramaniam, A., Zhang, F.S., Wimalawansa, S.J., Fischer, J.E. Brain Res. (1991)
- Central nervous system and other effects. Young, A. Adv. Pharmacol. (2005)
- Vascular actions of calcitonin gene-related peptide and adrenomedullin. Brain, S.D., Grant, A.D. Physiol. Rev. (2004)
- Islet amyloid polypeptide in patients with pancreatic cancer and diabetes. Permert, J., Larsson, J., Westermark, G.T., Herrington, M.K., Christmanson, L., Pour, P.M., Westermark, P., Adrian, T.E. N. Engl. J. Med. (1994)
- Islet amyloid, islet-amyloid polypeptide, and diabetes mellitus. Johnson, K.H., O'Brien, T.D., Betsholtz, C., Westermark, P. N. Engl. J. Med. (1989)
- Islet amyloid polypeptide (IAPP). A short review. Stridsberg, M., Wilander, E. Acta oncologica (Stockholm, Sweden) (1991)
- Chronic overproduction of islet amyloid polypeptide/amylin in transgenic mice: lysosomal localization of human islet amyloid polypeptide and lack of marked hyperglycaemia or hyperinsulinaemia. Höppener, J.W., Verbeek, J.S., de Koning, E.J., Oosterwijk, C., van Hulst, K.L., Visser-Vernooy, H.J., Hofhuis, F.M., van Gaalen, S., Berends, M.J., Hackeng, W.H. Diabetologia (1993)
- Adrenomedullin and calcitonin gene-related peptide interact with the same receptor in cultured human neuroblastoma SK-N-MC cells. Zimmermann, U., Fischer, J.A., Muff, R. Peptides (1995)
- Conservation of the sequence of islet amyloid polypeptide in five mammals is consistent with its putative role as an islet hormone. Nishi, M., Chan, S.J., Nagamatsu, S., Bell, G.I., Steiner, D.F. Proc. Natl. Acad. Sci. U.S.A. (1989)
- Antagonistic effect of human alpha-calcitonin gene-related peptide (8-37) on regional hemodynamic actions of rat islet amyloid polypeptide in conscious Long-Evans rats. Gardiner, S.M., Compton, A.M., Kemp, P.A., Bennett, T., Bose, C., Foulkes, R., Hughes, B. Diabetes (1991)
- Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death. Marzban, L., Rhodes, C.J., Steiner, D.F., Haataja, L., Halban, P.A., Verchere, C.B. Diabetes (2006)
- Is islet amyloid polypeptide a significant factor in pathogenesis or pathophysiology of diabetes? Steiner, D.F., Ohagi, S., Nagamatsu, S., Bell, G.I., Nishi, M. Diabetes (1991)
- Identifying structural features of fibrillar islet amyloid polypeptide using site-directed spin labeling. Jayasinghe, S.A., Langen, R. J. Biol. Chem. (2004)
- Two novel immortal pancreatic beta-cell lines expressing and secreting human islet amyloid polypeptide do not spontaneously develop islet amyloid. Andrikopoulos, S., Verchere, C.B., Teague, J.C., Howell, W.M., Fujimoto, W.Y., Wight, T.N., Kahn, S.E. Diabetes (1999)
- Identification of cis- and trans-active factors regulating human islet amyloid polypeptide gene expression in pancreatic beta-cells. Carty, M.D., Lillquist, J.S., Peshavaria, M., Stein, R., Soeller, W.C. J. Biol. Chem. (1997)
- Altered gene structure and tissue expression of islet amyloid polypeptide in the chicken. Fan, L., Westermark, G., Chan, S.J., Steiner, D.F. Mol. Endocrinol. (1994)
- Identification of a heparin binding domain in the N-terminal cleavage site of pro-islet amyloid polypeptide. Implications for islet amyloid formation. Park, K., Verchere, C.B. J. Biol. Chem. (2001)
- The mechanism of insulin action on islet amyloid polypeptide fiber formation. Larson, J.L., Miranker, A.D. J. Mol. Biol. (2004)
- Destabilization of human IAPP amyloid fibrils by proline mutations outside of the putative amyloidogenic domain: is there a critical amyloidogenic domain in human IAPP? Abedini, A., Raleigh, D.P. J. Mol. Biol. (2006)
- Insulin upstream factor 1 and a novel ubiquitous factor bind to the human islet amyloid polypeptide/amylin gene promoter. Bretherton-Watt, D., Gore, N., Boam, D.S. Biochem. J. (1996)
- Amylin receptor phenotypes derived from human calcitonin receptor/RAMP coexpression exhibit pharmacological differences dependent on receptor isoform and host cell environment. Tilakaratne, N., Christopoulos, G., Zumpe, E.T., Foord, S.M., Sexton, P.M. J. Pharmacol. Exp. Ther. (2000)
- Investigation and characterization of binding sites for islet amyloid polypeptide in rat membranes. Bhogal, R., Smith, D.M., Bloom, S.R. Endocrinology (1992)
- Expression of islet amyloid polypeptide in fetal and adult porcine and human pancreatic islet cells. Lukinius, A., Korsgren, O., Grimelius, L., Wilander, E. Endocrinology (1997)
- Whole-body autoradiography of 123I-labelled islet amyloid polypeptide (IAPP). Accumulation in the lung parenchyma and in the villi of the intestinal mucosa in rats. Stridsberg, M., Tjälve, H., Wilander, E. Acta oncologica (Stockholm, Sweden) (1993)
- Islet amyloid polypeptide stimulates cyclic AMP accumulation via the porcine calcitonin receptor. Christmanson, L., Westermark, P., Betsholtz, C. Biochem. Biophys. Res. Commun. (1994)
- Effect of pH and insulin on fibrillogenesis of islet amyloid polypeptide in vitro. Chargé, S.B., de Koning, E.J., Clark, A. Biochemistry (1995)
- Vasodilator responses to calcitonin gene-related peptide (CGRP) and amylin in the rat isolated perfused kidney are mediated via CGRP1 receptors. Chin, S.Y., Hall, J.M., Brain, S.D., Morton, I.K. J. Pharmacol. Exp. Ther. (1994)
- Hypocalcemic actions of amylin amide in humans. Wimalawansa, S.J., Gunasekera, R.D., Datta, H.K. J. Bone Miner. Res. (1992)
- Multiple amylin receptors arise from receptor activity-modifying protein interaction with the calcitonin receptor gene product. Christopoulos, G., Perry, K.J., Morfis, M., Tilakaratne, N., Gao, Y., Fraser, N.J., Main, M.J., Foord, S.M., Sexton, P.M. Mol. Pharmacol. (1999)
- Processing of pro-islet amyloid polypeptide (proIAPP) by the prohormone convertase PC2. Badman, M.K., Shennan, K.I., Jermany, J.L., Docherty, K., Clark, A. FEBS Lett. (1996)
- Phospholipid catalysis of diabetic amyloid assembly. Knight, J.D., Miranker, A.D. J. Mol. Biol. (2004)
- Islet amyloid polypeptide-like immunoreactivity in human tissue and endocrine tumors. Bretherton-Watt, D., Ghatei, M.A., Bloom, S.E., Williams, S., Bloom, S.R. J. Clin. Endocrinol. Metab. (1993)