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Gene Review

LIPF  -  lipase, gastric

Homo sapiens

Synonyms: GL, Gastric lipase, Gastric triacylglycerol lipase, HGL, HLAL
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Disease relevance of LIPF

  • To ascertain if an inadequate selection of patients might explain part of this variability, two different groups of patients with interstitial pulmonary fibrosis, those with the "lone" form of the disease (LIPF) and those with associated collagen vascular disorders (AIPF), were studied separately [1].
  • Recombinant HGL (r-HGL) was expressed in the baculovirus/insect cell system in the form of an active protein with a molecular mass of 45 kDa [2].
  • These observations suggest a significant role for nonpancreatic lipolytic activity (lingual lipase and gastric lipase) in fat digestion in patients with pancreatic insufficiency secondary to chronic alcohol abuse [3].
  • The aims of this study were to evaluate the amount of gastric lipase secreted by the stomach in normal adults and to elucidate a possible adaptative secretion of this enzyme in response to pancreatic insufficiency secondary to alcoholic chronic pancreatitis [4].
  • On the other hand, high gastric lipase outputs were found in eight patients with duodenal ulcers and no evidence of pancreatic dysfunction (23,180 +/- 262 U/h) [4].

High impact information on LIPF


Chemical compound and disease context of LIPF


Biological context of LIPF


Anatomical context of LIPF

  • RESULTS: At enrollment, patients with LIPF and AIPF were of similar age, and had similar symptoms and derangement of lung function, but patients with LIPF presented with finger clubbing, more obvious radiographic abnormalities, and a greater percentage of eosinophils in bronchoalveolar lavage fluid [1].
  • While no further activation occurred in the group of normal-hearing subjects, CI patients additionally recruited the right perirhinal/fusiform and mid-fusiform, the right temporo-occipito-parietal (TOP) junction and the left inferior prefrontal cortex (LIPF, Broca's area) [11].
  • Gastric lipase remained active in the duodenum where it might still hydrolyze 7.5% of the triglyceride acyl chains [8].
  • Comparison of the lipase activity levels in the gastric mucosa with lingual lipase activity levels in specimens of lingual serous glands indicates that in humans, gastric lipase is the main lipase active in the stomach [12].
  • RESULTS: HGL was localized in the secretory granules of gastric chief cells as early as 13 weeks [7].

Associations of LIPF with chemical compounds


Regulatory relationships of LIPF


Other interactions of LIPF

  • BACKGROUND & AIMS: It was recently reported that human gastric lipase (HGL) activity is modulated by epidermal growth factor (EGF) [7].
  • RESULTS: On a weight basis, the ratio of pancreatic lipase to gastric lipase total secretory outputs was found to be around four after 3 hours of digestion [8].
  • Hepatic LAL differed from fibroblast acid lipase at the N-terminus and revealed extensive similarities with human gastric lipase and rat lingual lipase, confirming a gene family of acid lipases [18].
  • The aim of this study was to examine the effect of gastrin on the gastric lipase secretion in patients with pancreatic insufficiency [19].
  • GLP-1 infused intravenously in amounts corresponding to the postprandial release significantly inhibited pentagastrin-stimulated gastric lipase secretion and lipolytic activity [20].

Analytical, diagnostic and therapeutic context of LIPF


  1. Interstitial pulmonary fibrosis with and without associated collagen vascular disease: results of a two year follow up. Agustí, C., Xaubet, A., Roca, J., Agustí, A.G., Rodriguez-Roisin, R. Thorax (1992) [Pubmed]
  2. Digestive lipases: from three-dimensional structure to physiology. Miled, N., Canaan, S., Dupuis, L., Roussel, A., Rivière, M., Carrière, F., de Caro, A., Cambillau, C., Verger, R. Biochimie (2000) [Pubmed]
  3. Role of nonpancreatic lipolytic activity in exocrine pancreatic insufficiency. Abrams, C.K., Hamosh, M., Dutta, S.K., Hubbard, V.S., Hamosh, P. Gastroenterology (1987) [Pubmed]
  4. Gastric lipase in alcoholic pancreatitis. Comparison of secretive profiles following pentagastrin stimulation in normal adults and patients with pancreatic insufficiency. Moreau, J., Bouisson, M., Balas, D., Ravaud, A., Stupnik, S., Buscail, L., Vaysse, N., Ribet, A. Gastroenterology (1990) [Pubmed]
  5. The complete digestion of human milk triacylglycerol in vitro requires gastric lipase, pancreatic colipase-dependent lipase, and bile salt-stimulated lipase. Bernbäck, S., Bläckberg, L., Hernell, O. J. Clin. Invest. (1990) [Pubmed]
  6. The specific activities of human digestive lipases measured from the in vivo and in vitro lipolysis of test meals. Carrière, F., Renou, C., Lopez, V., De Caro, J., Ferrato, F., Lengsfeld, H., De Caro, A., Laugier, R., Verger, R. Gastroenterology (2000) [Pubmed]
  7. Epidermal growth factor and transforming growth factor alpha down-regulate human gastric lipase gene expression. Tremblay, E., Basque, J.R., Rivard, N., Ménard, D. Gastroenterology (1999) [Pubmed]
  8. Secretion and contribution to lipolysis of gastric and pancreatic lipases during a test meal in humans. Carriere, F., Barrowman, J.A., Verger, R., Laugier, R. Gastroenterology (1993) [Pubmed]
  9. Mechanisms of inhibition of triacylglycerol hydrolysis by human gastric lipase. Pafumi, Y., Lairon, D., de la Porte, P.L., Juhel, C., Storch, J., Hamosh, M., Armand, M. J. Biol. Chem. (2002) [Pubmed]
  10. The acid lipase gene family: three enzymes, one highly conserved gene structure. Lohse, P., Lohse, P., Chahrokh-Zadeh, S., Seidel, D. J. Lipid Res. (1997) [Pubmed]
  11. The contribution of visual areas to speech comprehension: a PET study in cochlear implants patients and normal-hearing subjects. Giraud, A.L., Truy, E. Neuropsychologia. (2002) [Pubmed]
  12. Gastric lipase: localization in the human stomach. Abrams, C.K., Hamosh, M., Lee, T.C., Ansher, A.F., Collen, M.J., Lewis, J.H., Benjamin, S.B., Hamosh, P. Gastroenterology (1988) [Pubmed]
  13. Human lysosomal acid lipase/cholesteryl ester hydrolase and human gastric lipase: site-directed mutagenesis of Cys227 and Cys236 results in substrate-dependent reduction of enzymatic activity. Lohse, P., Lohse, P., Chahrokh-Zadeh, S., Seidel, D. J. Lipid Res. (1997) [Pubmed]
  14. The cysteine residues of recombinant human gastric lipase. Canaan, S., Rivière, M., Verger, R., Dupuis, L. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  15. Site-directed removal of N-glycosylation sites in human gastric lipase. Wicker-Planquart, C., Canaan, S., Rivière, M., Dupuis, L. Eur. J. Biochem. (1999) [Pubmed]
  16. Green tea extract (AR25) inhibits lipolysis of triglycerides in gastric and duodenal medium in vitro. Juhel, C., Armand, M., Pafumi, Y., Rosier, C., Vandermander, J., Lairon, D. J. Nutr. Biochem. (2000) [Pubmed]
  17. Secretin and gastric lipase secretion. Olsen, O., Wøjdemann, M., Berner, B., Christiansen, G., Sternby, B. Digestion (1998) [Pubmed]
  18. Purification, characterization and molecular cloning of human hepatic lysosomal acid lipase. Ameis, D., Merkel, M., Eckerskorn, C., Greten, H. Eur. J. Biochem. (1994) [Pubmed]
  19. Deficient gastric lipase secretion in pancreatic insufficiency. Wøjdemann, M., Olsen, O., Larsen, S., Sternby, B., Rehfeld, J.F. Scand. J. Gastroenterol. (1997) [Pubmed]
  20. Inhibition of human gastric lipase secretion by glucagon-like peptide-1. Wøjdemann, M., Wettergren, A., Sternby, B., Holst, J.J., Larsen, S., Rehfeld, J.F., Olsen, O. Dig. Dis. Sci. (1998) [Pubmed]
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