Disease relevance of Ischemic Preconditioning, Myocardial

• The results suggest that (1) preconditioning protects coronary endothelial cells against anoxia and reoxygenation injury, (2) the protection is probably mediated by activation of adenosine A2 receptors through the PKC pathway, and (3) the preservation of endothelial cells may be one of the mechanisms of myocardial preconditioning [1].
• CONCLUSION: Preadministration of isoflurane, before myocardial ischemia, reduces myocardial infarct size, and mimics myocardial preconditioning [2].
• For the first time, we have applied siRNA technique in the field of myocardial preconditioning to demonstrate HSF1 activation as an essential step in WBH preconditioning against cardiac ischemia-reperfusion injury [3].
• Because brief ischemia in kidneys or skeletal muscle limits infarct size produced by coronary artery occlusion, we investigated whether cardiac norepinephrine release during transient cerebral ischemia also elicits remote myocardial preconditioning [4].

High impact information on Ischemic Preconditioning, Myocardial

• In some animal species, myocardial preconditioning appears to be due to activation of ATP-sensitive K+ (KATP) channels [5].
• Myocardial preconditioning. Part of the adenosine revival [6].
• CONCLUSIONS: It is concluded that intracoronary application of dipyridamole may result in the induction of myocardial preconditioning by improving systolic and diastolic ventricular performance during percutaneous transluminal coronary angioplasty, thereby potentially reducing the risk of the angioplasty procedure [7].
• CONCLUSION: Nicorandil pretreatment resulted in the induction of myocardial preconditioning independent of the severity of ischaemia [8].
• CONCLUSION: These results show that glimepiride maintains myocardial preconditioning, while glibenclamide might be able to prevent it [9].

Anatomical context of Ischemic Preconditioning, Myocardial

• Possible role of cardiac mast cells in norepinephrine-induced myocardial preconditioning [10].

Associations of Ischemic Preconditioning, Myocardial with chemical compounds

• Mechanisms of isoflurane-induced myocardial preconditioning in rabbits [11].
• Role of bradykinin in myocardial preconditioning [12].
• Exercise-induced and nitroglycerin-induced myocardial preconditioning improves hemodynamics in patients with angina [13].
• Myocardial ischemic preconditioning in rodents is dependent on poly (ADP-ribose) synthetase [14].
• Mechanisms of sevoflurane-induced myocardial preconditioning in isolated human right atria in vitro [15].

Gene context of Ischemic Preconditioning, Myocardial

• COX-2: an in vivo evidence of its participation in heat stress-induced myocardial preconditioning [16].
• The objective of this study was to investigate the effects of PAR-2 in experimental myocardial ischemic preconditioning [17].
• We investigated the role of inducible heat shock proteins 70.1 and 70.3 (HSP70.1 and HSP70.3, respectively) in myocardial ischemic preconditioning (IP) in mice [18].
• Because protein kinase C (PKC)epsilon activation is necessary for myocardial ischemic preconditioning (IPC) and PKC activators increase SK activity, we tested the hypothesis that SK may be a central mediator of IPC [19].
• Since iNOS also appears to mediate various forms of myocardial preconditioning, the goal of this study was to investigate its role as a mediator of the HS response [20].

Analytical, diagnostic and therapeutic context of Ischemic Preconditioning, Myocardial

• Influence of selective 5-HT agonists and myocardial preconditioning on ischaemia/reperfusion induced changes in isolated heart of the rat [21].
• For example, although ACE inhibitors and calcium channel blockers are suitable agents, potassium channel openers cause myocardial preconditioning and decrease the infarct size in animal models, but they inhibit the insulin release after glucose administration in healthy subjects [22].

References