Gene Review:
F2rl1 - coagulation factor II (thrombin) receptor...
Rattus norvegicus
Synonyms:
Coagulation factor II receptor-like 1, PAR-2, Par-2, Par2, Proteinase-activated receptor 2, ...
Kawabata,
Kinoshita,
Nishikawa,
Kuroda,
Nishida,
Araki,
Arizono,
Oda,
Kakehi,
Bhattacharya,
Cohen,
Masamune,
Kikuta,
Satoh,
Suzuki,
Shimosegawa,
Kawabata,
Kawao,
Itoh,
Shimada,
Takebe,
Kuroda,
Masuko,
Kataoka,
Ogawa,
Kawabata,
Nakaya,
Ishiki,
Kubo,
Kuroda,
Sekiguchi,
Kawao,
Nishikawa,
Kawai,
Dinh,
Cryer,
Dinh,
Trevisani,
Georgiewa,
Chung,
Geppetti,
Heppt,
Klapp,
Fischer,
Kawabata,
Morimoto,
Nishikawa,
Kuroda,
Oda,
Kakehi,
Sobey,
Moffatt,
Cocks,
- Proteinases and proteinase-activated receptor 2: a possible role to promote visceral hyperalgesia in rats. Coelho, A.M., Vergnolle, N., Guiard, B., Fioramonti, J., Bueno, L. Gastroenterology (2002)
- Redundant signaling mechanisms contribute to the vasodilatory response of the afferent arteriole to proteinase-activated receptor-2. Wang, X., Hollenberg, M.D., Loutzenhiser, R. Am. J. Physiol. Renal Physiol. (2005)
- Protease-activated receptor-2 modulates myocardial ischemia-reperfusion injury in the rat heart. Napoli, C., Cicala, C., Wallace, J.L., de Nigris, F., Santagada, V., Caliendo, G., Franconi, F., Ignarro, L.J., Cirino, G. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Evidence for selective effects of chronic hypertension on cerebral artery vasodilatation to protease-activated receptor-2 activation. Sobey, C.G., Moffatt, J.D., Cocks, T.M. Stroke (1999)
- Neurogenic components of trypsin- and thrombin-induced inflammation in rat skin, in vivo. Obreja, O., Rukwied, R., Steinhoff, M., Schmelz, M. Exp. Dermatol. (2006)
- The protease-activated receptor-2 agonist induces gastric mucus secretion and mucosal cytoprotection. Kawabata, A., Kinoshita, M., Nishikawa, H., Kuroda, R., Nishida, M., Araki, H., Arizono, N., Oda, Y., Kakehi, K. J. Clin. Invest. (2001)
- Role of N-methyl-D-aspartate receptors and the nitric oxide pathway in nociception/hyperalgesia elicited by protease-activated receptor-2 activation in mice and rats. Kawabata, A., Kawao, N., Itoh, H., Shimada, C., Takebe, K., Kuroda, R., Masuko, T., Kataoka, K., Ogawa, S. Neurosci. Lett. (2002)
- Intrathecal protease-activated receptor stimulation produces thermal hyperalgesia through spinal cyclooxygenase activity. Koetzner, L., Gregory, J.A., Yaksh, T.L. J. Pharmacol. Exp. Ther. (2004)
- Protease-activated receptor-2-mediated proliferation and collagen production of rat pancreatic stellate cells. Masamune, A., Kikuta, K., Satoh, M., Suzuki, N., Shimosegawa, T. J. Pharmacol. Exp. Ther. (2005)
- Protease-activated receptor-2-mediated contraction of urinary bladder is enhanced in cyclophosphamide-treated rats. Nakahara, T., Kubota, Y., Saito, M., Sakamoto, K., Ishii, K. Naunyn Schmiedebergs Arch. Pharmacol. (2004)
- PAR-2 elicits afferent arteriolar vasodilation by NO-dependent and NO-independent actions. Trottier, G., Hollenberg, M., Wang, X., Gui, Y., Loutzenhiser, K., Loutzenhiser, R. Am. J. Physiol. Renal Physiol. (2002)
- Proteinase-activated receptor 2 (PAR2)-activating peptides: identification of a receptor distinct from PAR2 that regulates intestinal transport. Vergnolle, N., Macnaughton, W.K., Al-Ani, B., Saifeddine, M., Wallace, J.L., Hollenberg, M.D. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Evidence for the presence of a proteinase-activated receptor distinct from the thrombin receptor in vascular endothelial cells. Hwa, J.J., Ghibaudi, L., Williams, P., Chintala, M., Zhang, R., Chatterjee, M., Sybertz, E. Circ. Res. (1996)
- Vascular contraction and relaxation to thrombin and trypsin: thrombomodulin preferentially attenuates thrombin-induced contraction. Bhattacharya, A., Cohen, M.L. J. Pharmacol. Exp. Ther. (2000)
- Four subtypes of protease-activated receptors, co-expressed in rat astrocytes, evoke different physiological signaling. Wang, H., Ubl, J.J., Reiser, G. Glia (2002)
- Proteinase-activated receptor (PAR)-1 and -2 agonists induce mediator release from mast cells by pathways distinct from PAR-1 and PAR-2. Stenton, G.R., Nohara, O., Déry, R.E., Vliagoftis, H., Gilchrist, M., Johri, A., Wallace, J.L., Hollenberg, M.D., Moqbel, R., Befus, A.D. J. Pharmacol. Exp. Ther. (2002)
- Rat proteinase-activated receptor-2 (PAR-2): cDNA sequence and activity of receptor-derived peptides in gastric and vascular tissue. Saifeddine, M., al-Ani, B., Cheng, C.H., Wang, L., Hollenberg, M.D. Br. J. Pharmacol. (1996)
- Receptor-activating peptides for PAR-1 and PAR-2 relax rat gastric artery via multiple mechanisms. Kawabata, A., Nakaya, Y., Ishiki, T., Kubo, S., Kuroda, R., Sekiguchi, F., Kawao, N., Nishikawa, H., Kawai, K. Life Sci. (2004)
- Bidirectional regulation of renal hemodynamics by activation of PAR1 and PAR2 in isolated perfused rat kidney. Gui, Y., Loutzenhiser, R., Hollenberg, M.D. Am. J. Physiol. Renal Physiol. (2003)
- Proteinase activated receptor 2: Role of extracellular loop 2 for ligand-mediated activation. Al-Ani, B., Saifeddine, M., Kawabata, A., Hollenberg, M.D. Br. J. Pharmacol. (1999)
- Protease-activated receptor 2 expression in trigeminal neurons innervating the rat nasal mucosa. Dinh, Q.T., Cryer, A., Dinh, S., Trevisani, M., Georgiewa, P., Chung, F., Geppetti, P., Heppt, W., Klapp, B.F., Fischer, A. Neuropeptides (2005)
- Activation of protease-activated receptor-2 (PAR-2) triggers mucin secretion in the rat sublingual gland. Kawabata, A., Morimoto, N., Nishikawa, H., Kuroda, R., Oda, Y., Kakehi, K. Biochem. Biophys. Res. Commun. (2000)
- Capsazepine inhibits thermal hyperalgesia but not nociception triggered by protease-activated receptor-2 in rats. Kawao, N., Shimada, C., Itoh, H., Kuroda, R., Kawabata, A. Jpn. J. Pharmacol. (2002)
- Expression of protease-activated receptors (PARs) in OLN-93 oligodendroglial cells and mechanism of PAR-1-induced calcium signaling. Wang, Y., Richter-Landsberg, C., Reiser, G. Neuroscience (2004)
- Four different types of protease-activated receptors are widely expressed in the brain and are up-regulated in hippocampus by severe ischemia. Striggow, F., Riek-Burchardt, M., Kiesel, A., Schmidt, W., Henrich-Noack, P., Breder, J., Krug, M., Reymann, K.G., Reiser, G. Eur. J. Neurosci. (2001)
- Suppression by protease-activated receptor-2 activation of gastric acid secretion in rats. Nishikawa, H., Kawai, K., Nishimura, S., Tanaka, S., Araki, H., Al-Ani, B., Hollenberg, M.D., Kuroda, R., Kawabata, A. Eur. J. Pharmacol. (2002)
- Protease-activated receptor-2 activation improves efficiency of experimental ischemic preconditioning. Napoli, C., De Nigris, F., Cicala, C., Wallace, J.L., Caliendo, G., Condorelli, M., Santagada, V., Cirino, G. Am. J. Physiol. Heart Circ. Physiol. (2002)