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Gene Review

HAT22  -  homeobox-leucine zipper protein HAT22

Arabidopsis thaliana

Synonyms: HOMEOBOX PROTEIN, T28I19.70, T28I19_70
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Disease relevance of HAT22


High impact information on HAT22

  • AS1 encodes a myb domain protein, closely related to PHANTASTICA in Antirrhinum and ROUGH SHEATH2 in maize, both of which negatively regulate knotted-class homeobox genes [3].
  • The knotted1-like homeobox gene BREVIPEDICELLUS regulates cell differentiation by modulating metabolic pathways [4].
  • The Arabidopsis thaliana ASYMMETRIC LEAVES1 (AS1) and AS2 genes are important for repressing class I KNOTTED1-like homeobox (KNOX) genes and specifying leaf adaxial identity in leaf development [5].
  • The mutant develops ectopic stipules on the petiole-rachis axis, which are associated with ectopic class 1 KNOTTED1-like homeobox (KNOX) gene expression, showing that the interaction between CRISPA and the KNOX gene PISUM SATIVUM KNOTTED2 specifies stipule boundaries [6].
  • In the Arabidopsis thaliana shoot meristem, the homeobox gene WUSCHEL (WUS) is expressed in the organizing center underneath the stem cells and integrates regulatory information from several pathways to define the boundaries of the stem cell niche [7].

Biological context of HAT22


Associations of HAT22 with chemical compounds


Other interactions of HAT22


Analytical, diagnostic and therapeutic context of HAT22


  1. KNAT1 induces lobed leaves with ectopic meristems when overexpressed in Arabidopsis. Chuck, G., Lincoln, C., Hake, S. Plant Cell (1996) [Pubmed]
  2. Developmental regulation and significance of KNOX protein trafficking in Arabidopsis. Kim, J.Y., Yuan, Z., Jackson, D. Development (2003) [Pubmed]
  3. Asymmetric leaves1 mediates leaf patterning and stem cell function in Arabidopsis. Byrne, M.E., Barley, R., Curtis, M., Arroyo, J.M., Dunham, M., Hudson, A., Martienssen, R.A. Nature (2000) [Pubmed]
  4. The knotted1-like homeobox gene BREVIPEDICELLUS regulates cell differentiation by modulating metabolic pathways. Mele, G., Ori, N., Sato, Y., Hake, S. Genes Dev. (2003) [Pubmed]
  5. The Putative RNA-dependent RNA polymerase RDR6 acts synergistically with ASYMMETRIC LEAVES1 and 2 to repress BREVIPEDICELLUS and MicroRNA165/166 in Arabidopsis leaf development. Li, H., Xu, L., Wang, H., Yuan, Z., Cao, X., Yang, Z., Zhang, D., Xu, Y., Huang, H. Plant Cell (2005) [Pubmed]
  6. The mutant crispa reveals multiple roles for PHANTASTICA in pea compound leaf development. Tattersall, A.D., Turner, L., Knox, M.R., Ambrose, M.J., Ellis, T.H., Hofer, J.M. Plant Cell (2005) [Pubmed]
  7. Regulation of WUSCHEL transcription in the stem cell niche of the Arabidopsis shoot meristem. Bäurle, I., Laux, T. Plant Cell (2005) [Pubmed]
  8. Negative autoregulation of the Arabidopsis homeobox gene ATHB-2. Ohgishi, M., Oka, A., Morelli, G., Ruberti, I., Aoyama, T. Plant J. (2001) [Pubmed]
  9. Expression patterns of novel genes encoding homeodomain leucine-zipper proteins in Arabidopsis thaliana. Söderman, E., Mattsson, J., Svenson, M., Borkird, C., Engström, P. Plant Mol. Biol. (1994) [Pubmed]
  10. Identification of a meristem L1 layer-specific gene in Arabidopsis that is expressed during embryonic pattern formation and defines a new class of homeobox genes. Lu, P., Porat, R., Nadeau, J.A., O'Neill, S.D. Plant Cell (1996) [Pubmed]
  11. The expression of the Athb-8 homeobox gene is restricted to provascular cells in Arabidopsis thaliana. Baima, S., Nobili, F., Sessa, G., Lucchetti, S., Ruberti, I., Morelli, G. Development (1995) [Pubmed]
  12. The maize duplicate genes narrow sheath1 and narrow sheath2 encode a conserved homeobox gene function in a lateral domain of shoot apical meristems. Nardmann, J., Ji, J., Werr, W., Scanlon, M.J. Development (2004) [Pubmed]
  13. Structure of homeobox-leucine zipper genes suggests a model for the evolution of gene families. Schena, M., Davis, R.W. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  14. The HAT2 gene, a member of the HD-Zip gene family, isolated as an auxin inducible gene by DNA microarray screening, affects auxin response in Arabidopsis. Sawa, S., Ohgishi, M., Goda, H., Higuchi, K., Shimada, Y., Yoshida, S., Koshiba, T. Plant J. (2002) [Pubmed]
  15. The Arabidopsis homeobox gene ATHB-7 is induced by water deficit and by abscisic acid. Söderman, E., Mattsson, J., Engström, P. Plant J. (1996) [Pubmed]
  16. Induction of a homeodomain-leucine zipper gene by auxin is inhibited by cytokinin in Arabidopsis roots. Son, O., Cho, H.Y., Kim, M.R., Lee, H., Lee, M.S., Song, E., Park, J.H., Nam, K.H., Chun, J.Y., Kim, H.J., Hong, S.K., Chung, Y.Y., Hur, C.G., Cho, H.T., Cheon, C.I. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  17. HD-Zip proteins: members of an Arabidopsis homeodomain protein superfamily. Schena, M., Davis, R.W. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  18. Phytochromes B, D, and E act redundantly to control multiple physiological responses in Arabidopsis. Franklin, K.A., Praekelt, U., Stoddart, W.M., Billingham, O.E., Halliday, K.J., Whitelam, G.C. Plant Physiol. (2003) [Pubmed]
  19. The Arabidopsis Athb-8, -9 and -14 genes are members of a small gene family coding for highly related HD-ZIP proteins. Sessa, G., Steindler, C., Morelli, G., Ruberti, I. Plant Mol. Biol. (1998) [Pubmed]
  20. Regulation of CLV3 expression by two homeobox genes in Arabidopsis. Brand, U., Grünewald, M., Hobe, M., Simon, R. Plant Physiol. (2002) [Pubmed]
  21. Phyllotactic pattern and stem cell fate are determined by the Arabidopsis homeobox gene BELLRINGER. Byrne, M.E., Groover, A.T., Fontana, J.R., Martienssen, R.A. Development (2003) [Pubmed]
  22. A new homeodomain-leucine zipper gene from Arabidopsis thaliana induced by water stress and abscisic acid treatment. Lee, Y.H., Chun, J.Y. Plant Mol. Biol. (1998) [Pubmed]
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