Disease relevance of HAT22

• Using in situ hybridization, we analyzed the expression of KNAT1 and another kn1-like homeobox gene, SHOOT MERISTEMLESS, in cauliflower mosaic virus 35S::KNAT1 transformants [1].
• We have compared the intercellular trafficking of green fluorescent protein (GFP) fusions of KN1 and Arabidopsis KN1-related homeobox proteins to that of the viral movement protein from turnip vein clearing tobamovirus [2].

High impact information on HAT22

• AS1 encodes a myb domain protein, closely related to PHANTASTICA in Antirrhinum and ROUGH SHEATH2 in maize, both of which negatively regulate knotted-class homeobox genes [3].
• The knotted1-like homeobox gene BREVIPEDICELLUS regulates cell differentiation by modulating metabolic pathways [4].
• The Arabidopsis thaliana ASYMMETRIC LEAVES1 (AS1) and AS2 genes are important for repressing class I KNOTTED1-like homeobox (KNOX) genes and specifying leaf adaxial identity in leaf development [5].
• The mutant develops ectopic stipules on the petiole-rachis axis, which are associated with ectopic class 1 KNOTTED1-like homeobox (KNOX) gene expression, showing that the interaction between CRISPA and the KNOX gene PISUM SATIVUM KNOTTED2 specifies stipule boundaries [6].
• In the Arabidopsis thaliana shoot meristem, the homeobox gene WUSCHEL (WUS) is expressed in the organizing center underneath the stem cells and integrates regulatory information from several pathways to define the boundaries of the stem cell niche [7].

Biological context of HAT22

• Negative autoregulation of the Arabidopsis homeobox gene ATHB-2 [8].
• These observations indicate that these Athb genes have major functions in the mature plant, and therefore, in contrast to homeobox genes in other eukaryotes and to the kn-1 gene in maize, are unlikely to function in the primary control of developmental processes during embryogenesis or organogenesis [9].
• Identification of a meristem L1 layer-specific gene in Arabidopsis that is expressed during embryonic pattern formation and defines a new class of homeobox genes [10].
• We have characterized an Arabidopsis homeobox gene coding for a putative DNA binding protein that represents an early marker for vascular development [11].
• The maize duplicate genes narrow sheath1 and narrow sheath2 encode a conserved homeobox gene function in a lateral domain of shoot apical meristems [12].

Associations of HAT22 with chemical compounds

• The model postulates that a primordial homeobox gene acquired a leucine zipper by exon capture [13].
• Of the genes that responded to auxin, the expression of the homeobox gene, HAT2, was induced rapidly [14].
• The Arabidopsis homeobox gene ATHB-7 is induced by water deficit and by abscisic acid [15].
• We chose eight putative Arabidopsis homeobox genes not previously characterized and examined their expression in response to treatment with auxin/cytokinin [16].

Other interactions of HAT22

• Homeobox genes encode a large family of homeodomain proteins in animal systems [17].
• The creation of triple and quadruple mutants in Arabidopsis, deficient in multiple phytochromes, has revealed functional redundancy between phyB, D, and E in controlling flowering time, leaf development, and regulation of the homeobox gene, ATHB-2 [18].
• We report the isolation and characterization of two Arabidopsis homeobox genes highly related to the Athb-8 gene [19].
• Regulation of CLV3 expression by two homeobox genes in Arabidopsis [20].
• Phyllotactic pattern and stem cell fate are determined by the Arabidopsis homeobox gene BELLRINGER [21].

Analytical, diagnostic and therapeutic context of HAT22

• We report the isolation and characterization of a new homeobox gene from Arabidopsis thaliana using a polymerase chain reaction (PCR) cloning strategy [22].

References