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Rats, Inbred LEC

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  1. Decreased expression of liver glutathione peroxidase in Long-Evans cinnamon mutant rats predisposed to hepatitis and hepatoma. Suemizu, H., Yoshimura, S., Takeichi, N., Moriuchi, T. Hepatology (1994) [Pubmed]
  2. Dissolution of copper-rich granules in hepatic lysosomes by D-penicillamine prevents the development of fulminant hepatitis in Long-Evans cinnamon rats. Klein, D., Lichtmannegger, J., Heinzmann, U., Summer, K.H. J. Hepatol. (2000) [Pubmed]
  3. Copper-metallothionein distribution in the liver of Long-Evans cinnamon rats: studies on immunohistochemical staining, metal determination, gel filtration and electron spin resonance spectroscopy. Sakurai, H., Nakajima, K., Kamada, H., Satoh, H., Otaki, N., Kimura, M., Kawano, K., Hagino, T. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  4. Inhibition of hereditary hepatitis and liver tumor development in Long-Evans cinnamon rats by the copper-chelating agent trientine dihydrochloride. Sone, K., Maeda, M., Wakabayashi, K., Takeichi, N., Mori, M., Sugimura, T., Nagao, M. Hepatology (1996) [Pubmed]
  5. Prevention of spontaneous hepatocellular carcinoma in Long-Evans cinnamon rats with hereditary hepatitis by the administration of D-penicillamine. Jong-Hon, K., Togashi, Y., Kasai, H., Hosokawa, M., Takeichi, N. Hepatology (1993) [Pubmed]
  6. Biliary excretion of copper, metallothionein, and glutathione into Long-Evans Cinnamon rats: a convincing animal model for Wilson disease. Sugawara, N., Sato, M., Yuasa, M., Sugawara, C. Biochem. Mol. Med. (1995) [Pubmed]
  7. A possible novel src-related tyrosine kinase in cancer cells of LEC rats that develop hepatocellular carcinoma. Masaki, T., Tokuda, M., Shiratori, Y., Shirai, M., Matsumoto, K., Nishioka, M., Omata, M. J. Hepatol. (2000) [Pubmed]
  8. Histological changes in monoaminergic neurons of Long-Evans Cinnamon rats. Kawano, H., Takeuchi, Y., Yoshimoto, K., Matsumoto, K., Sugimoto, T. Brain Res. (2001) [Pubmed]
  9. Unusual generation of hydroxyl radicals in hepatic copper-metallothionein of LEC (Long-Evans cinnamon) rats in the presence of hydrogen peroxide. Sakurai, H., Satoh, H., Hatanaka, A., Sawada, T., Kawano, K., Hagino, T., Nakajima, K. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  10. Elevated level of 8-hydroxydeoxyguanosine in DNA of liver, kidneys, and brain of Long-Evans Cinnamon rats. Yamamoto, F., Kasai, H., Togashi, Y., Takeichi, N., Hori, T., Nishimura, S. Jpn. J. Cancer Res. (1993) [Pubmed]
  11. Analysis of CA repeats in first intron of class I ADH gene in Long-Evans Cinnamon rats developing fatal intoxication after ethanol intake. Katsuki, S., Kato, J., Nakajima, M., Inui, N., Sasaki, K., Kohgo, Y., Niitsu, Y. Alcohol. Clin. Exp. Res. (1996) [Pubmed]
  12. Excess dietary histidine decreases the liver copper level and serum alanine aminotransferase activity in Long-Evans Cinnamon rats. Xu, H., Sakakibara, S., Morifuji, M., Salamatulla, Q., Aoyama, Y. Br. J. Nutr. (2003) [Pubmed]
  13. Proline, ascorbic acid, or thioredoxin affect jaundice and mortality in Long Evans cinnamon rats. Hawkins, R.L., Mori, M., Inoue, M., Torii, K. Pharmacol. Biochem. Behav. (1995) [Pubmed]
  14. Preventive effects of the deleted form of hepatocyte growth factor against various liver injuries. Masunaga, H., Fujise, N., Shiota, A., Ogawa, H., Sato, Y., Imai, E., Yasuda, H., Higashio, K. Eur. J. Pharmacol. (1998) [Pubmed]
  15. D-penicillamine prevents the development of hepatitis in Long-Evans Cinnamon rats with abnormal copper metabolism. Togashi, Y., Li, Y., Kang, J.H., Takeichi, N., Fujioka, Y., Nagashima, K., Kobayashi, H. Hepatology (1992) [Pubmed]
  16. Magnetic resonance imaging of Long-Evans cinnamon rats as a new model of hepatocellular carcinoma. Nakakoshi, T., Kajiyama, M., Fujita, N., Jong-Hon, K., Takeichi, N., Miyasaka, K. Academic radiology. (1995) [Pubmed]
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