Disease relevance of Sleep Bruxism

• Occlusal adjustment and myoelectric activity of the jaw elevator muscles in patients with nocturnal bruxism and craniomandibular disorders [1].
• Chronic headache and nocturnal bruxism in a 5-year-old child treated with an occlusal splint [2].
• A proposed mechanism for diurnal/nocturnal bruxism: hypersensitivity of presynaptic dopamine receptors in the frontal lobe [3].
• Topics include sleep-related bruxism, xerostomia, hypersalivation, gastroesophageal reflux, apnea, and the effect of orofacial pain on sleep quality [4].

Psychiatry related information on Sleep Bruxism

• Under clonidine, duration of sleep stage 2 was prolonged, whereas REM sleep was suppressed in 14 of 16 subjects with sleep bruxism [5].
• On the pharmacotherapy of sleep bruxism: placebo-controlled polysomnographic and psychometric studies with clonazepam [6].

High impact information on Sleep Bruxism

• Sleep and sleep bruxism variables were not significantly influenced by propranolol [5].
• STUDY OBJECTIVE: To examine whether 2 sympatholytic medications decrease sleep bruxism and prevent the rise in sympathetic activity preceding the onset of sleep bruxism: propranolol, a nonselective adrenergic beta-blocker, and clonidine, a selective alpha2-agonist [5].
• CONCLUSIONS: Nocturnal bruxism may be secondary to nocturnal gastroesophageal reflux, occurring via sleep arousal and often together with swallowing [7].
• In addition, they suggest that a decrease in SSRI dosage or the addition of buspirone may relieve SSRI-associated nocturnal bruxism [8].
• RESULTS: Four patients developed nocturnal bruxism within 2 to 4 weeks after initiation of treatment with fluoxetine or sertraline [8].

Chemical compound and disease context of Sleep Bruxism

• CONCLUSION: These observations, which should be confirmed by a controlled study, suggest an association between serotonin selective reuptake inhibitor (SSRI) treatment and the onset or exacerbation of nocturnal bruxism [8].
• An altered dopamine receptor status has been associated with sleep bruxism [9].
• The aim of this study was to investigate the possible impact of nocturnal bruxism on Hg exposure from dental amalgams and to evaluate the effect of an occlusal appliance [10].
• This experiment was designed to study the effect of L-tryptophan on nocturnal bruxism [11].
• They differed from the usual features of nocturnal bruxism in hypoperfusion of the left frontal lobe, a poor response to l-dopa or bromocriptine therapy and a favourable response to metoclopramide [3].

Anatomical context of Sleep Bruxism

• The effects of occlusal adjustments on the myoelectric activity of the anterior temporal and masseter muscles, with the mandible at rest and during maximal clenching in the intercuspal position (ICP), were studied in 24 nocturnal bruxism patients [1].

Gene context of Sleep Bruxism

• It was concluded that an abnormal side imbalance in striatal D2 receptor expression can be associated with sleep bruxism [12].
• Influence of nocturnal bruxism on the stomatognathic system. Part I: a new device for measuring mandibular movements during sleep [13].

Analytical, diagnostic and therapeutic context of Sleep Bruxism

• To assess the significance of this finding, we studied the effects of short-term administration of the preferential dopamine D2 receptor agonist bromocriptine on sleep bruxism in a double-blind, placebo-controlled polysomnographic and neuro-imaging study with a single crossover design [9].
• In association with this polysomnographically established attenuation of sleep bruxism, bromocriptine afforded a decreased normal side distribution of striatal D2 receptor binding, as was evidenced by single-photon-emission computed tomography using the radioactive D2 receptor antagonist iodine-123-iodobenzamide [9].
• This clinical report describes an approach to restore canine guidance on an occlusal splint, with amalgam, for a patient with sleep bruxism [14].
• MATERIAL AND METHODS: Subjects with known history of nocturnal bruxism were given heat-cured full-arch acrylic resin occlusal stabilization splints to be worn nocturnally for 3 months [15].

References