The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Sialorrhea


Psychiatry related information on Sialorrhea


High impact information on Sialorrhea


Chemical compound and disease context of Sialorrhea


Biological context of Sialorrhea


Anatomical context of Sialorrhea

  • The sialorrhea was associated with salivary gland enlargement and was reversed by discontinuation of lithium [11].
  • Oro-facial manifestations include bilateral facial nerve palsy resulting in a mask like facies, drooling, incomplete eye closure, and strabismus secondary to the extra-ocular muscle imbalance [22].
  • PATIENTS AND METHODS: Thirteen patients with drooling caused by head and neck carcinoma, neurodegenerative diseases, or stroke received injections of 50 to 65 U botulinum toxin A (Botox; Allergan, Irvine, CA) in both submandibular and both parotid glands under sonographic control [23].
  • Except for the deficiency of dehydratase, an enzyme catalyzing a reaction in the recycling pathway, all other variants of BH4 deficiency are characterized by developmental delay, progressive neurological deterioration, hypokinesis, drooling, swallowing difficulty, truncal hypotonia, increased limb tone, myoclonus and brisk deep tendon reflexes [24].
  • These results suggest that GR-205171 acts on the afferent pathway in the bulb and diminishes hypersalivation and antral contraction related to emesis as well as fictive retching but does not affect gastric relaxation or hypersalivation induced by the vagovagal, vagosalivary, and linguosalivary reflexes [25].

Gene context of Sialorrhea


Analytical, diagnostic and therapeutic context of Sialorrhea


  1. Extrapyramidal involvement in Rett's syndrome. FitzGerald, P.M., Jankovic, J., Glaze, D.G., Schultz, R., Percy, A.K. Neurology (1990) [Pubmed]
  2. A randomized controlled trial of risperidone in the treatment of aggression in hospitalized adolescents with subaverage cognitive abilities. Buitelaar, J.K., van der Gaag, R.J., Cohen-Kettenis, P., Melman, C.T. The Journal of clinical psychiatry. (2001) [Pubmed]
  3. Glycopyrrolate treatment of chronic drooling. Blasco, P.A., Stansbury, J.C. Archives of pediatrics & adolescent medicine. (1996) [Pubmed]
  4. A qualitative assessment of the neurological safety of antipsychotic drugs; an analysis of a risperidone database. Fleischhacker, W.W., Lemmens, P., van Baelen, B. Pharmacopsychiatry (2001) [Pubmed]
  5. Sublingual atropine for sialorrhea secondary to parkinsonism: a pilot study. Hyson, H.C., Johnson, A.M., Jog, M.S. Mov. Disord. (2002) [Pubmed]
  6. Concurrent use of clozapine and valproate in affective and psychotic disorders. Kando, J.C., Tohen, M., Castillo, J., Centorrino, F. The Journal of clinical psychiatry. (1994) [Pubmed]
  7. Biphasic illness pattern due to early relapse in Japanese-B virus encephalitis. Pradhan, S., Gupta, R.K., Singh, M.B., Mathur, A. J. Neurol. Sci. (2001) [Pubmed]
  8. Atypical experience: a case series of pediatric aripiprazole exposures. Lofton, A.L., Klein-Schwartz, W. Clinical toxicology (Philadelphia, Pa.) (2005) [Pubmed]
  9. The mechanism of nitrazepam-induced drooling and aspiration. Wyllie, E., Wyllie, R., Cruse, R.P., Rothner, A.D., Erenberg, G. N. Engl. J. Med. (1986) [Pubmed]
  10. Intermittent cough, sulfur-tasting sputum, and hypersalivation associated with captopril. Biron, P. Arch. Intern. Med. (1988) [Pubmed]
  11. Sialorrhea as a side effect of lithium: a case report. Donaldson, S.R. The American journal of psychiatry. (1982) [Pubmed]
  12. Clozapine-induced sialorrhea treated with sublingual ipratropium spray: a case series. Freudenreich, O., Beebe, M., Goff, D.C. Journal of clinical psychopharmacology. (2004) [Pubmed]
  13. Guanfacine treatment of clozapine-induced sialorrhea. Webber, M.A., Szwast, S.J., Steadman, T.M., Frazer, A., Malloy, F.W., Lightfoot, J.D., Shekhar, A. Journal of clinical psychopharmacology. (2004) [Pubmed]
  14. Clonidine treatment of clozapine-induced hypersalivation. Grabowski, J. Journal of clinical psychopharmacology. (1992) [Pubmed]
  15. Potentiation by propofol of the response of rat submandibular acinar cells to purinergic agonists. Fernandez, M., Pochet, S., Chaïb, N., Métioui, M., Gómez-Muñoz, A., Marino, A., Dehaye, J.P. Cell Calcium (2001) [Pubmed]
  16. Peroxidase antimicrobial system of human saliva: hypothiocyanite levels in resting and stimulated saliva. Tenovuo, J., Pruitt, K.M., Thomas, E.L. J. Dent. Res. (1982) [Pubmed]
  17. Treatment of sialorrhea with glycopyrrolate: A double-blind, dose-ranging study. Mier, R.J., Bachrach, S.J., Lakin, R.C., Barker, T., Childs, J., Moran, M. Archives of pediatrics & adolescent medicine. (2000) [Pubmed]
  18. Crossover clinical trial of benapryzine and trihexyphenidyl in Parkinsonian patients. Lamid, S., Jenkins, R.B. Journal of clinical pharmacology. (1975) [Pubmed]
  19. Modafinil for drooling in cerebral palsy. Hurst, D., Cedrone, N. J. Child Neurol. (2006) [Pubmed]
  20. Sialorrhea: a review of a vexing, often unrecognized sign of oropharyngeal and esophageal disease. Boyce, H.W., Bakheet, M.R. J. Clin. Gastroenterol. (2005) [Pubmed]
  21. Hyperkalaemic periodic paralysis in homozygous and heterozygous horses: a co-dominant genetic condition. Naylor, J.M., Nickel, D.D., Trimino, G., Card, C., Lightfoot, K., Adams, G. Equine Vet. J. (1999) [Pubmed]
  22. Anesthetic management of children with Moebius sequence. Ames, W.A., Shichor, T.M., Speakman, M., Zuker, R.M., McCaul, C. Canadian journal of anaesthesia = Journal canadien d'anesthésie. (2005) [Pubmed]
  23. Up-to-date report of botulinum toxin therapy in patients with drooling caused by different etiologies. Ellies, M., Laskawi, R., Rohrbach-Volland, S., Arglebe, C. J. Oral Maxillofac. Surg. (2003) [Pubmed]
  24. Guanosine triphosphate cyclohydrolase I deficiency: a rare cause of hyperphenylalaninemia. Coşkun, T., Karagöz, T., Kalkanoğlu, S., Tokatli, A., Ozalp, I., Thöny, B., Blau, N. Turk. J. Pediatr. (1999) [Pubmed]
  25. A neurokinin-1 receptor antagonist reduced hypersalivation and gastric contractility related to emesis in dogs. Furukawa, N., Fukuda, H., Hatano, M., Koga, T., Shiroshita, Y. Am. J. Physiol. (1998) [Pubmed]
  26. General pharmacological studies on N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate. 2nd communication: effect on the peripheral nervous system and peripheral organs. Hirotsu, I., Kihara, T., Hattori, Y., Hatta, M., Hirose, N., Ishihara, T., Satoh, F. Arzneimittel-Forschung. (1988) [Pubmed]
  27. Hypersalivation in temporal lobe epilepsy. Shah, J., Zhai, H., Fuerst, D., Watson, C. Epilepsia (2006) [Pubmed]
  28. Macrocephaly with hamartomas: Bannayan-Zonana syndrome. Miles, J.H., Zonana, J., Mcfarlane, J., Aleck, K.A., Bawle, E. Am. J. Med. Genet. (1984) [Pubmed]
  29. Dyslipidaemia in a boy with recurrent abdominal pain, hypersalivation and decreased lipoprotein lipase activity. Matern, D., Seydewitz, H., Niederhoff, H., Wiebusch, H., Brandis, M. Eur. J. Pediatr. (1996) [Pubmed]
  30. Multiple dose-activated charcoal as a cause of acute appendicitis. Eroglu, A., Kucuktulu, U., Erciyes, N., Turgutalp, H. J. Toxicol. Clin. Toxicol. (2003) [Pubmed]
  31. Amisulpride treatment of clozapine-induced hypersalivation in schizophrenia patients: a randomized, double-blind, placebo-controlled cross-over study. Kreinin, A., Novitski, D., Weizman, A. International clinical psychopharmacology. (2006) [Pubmed]
  32. Kainic acid may enhance hippocampal NO generation of awake rats in a seizure stage-related fashion. Kashihara, K., Sakai, K., Marui, K., Shohmori, T. Neurosci. Res. (1998) [Pubmed]
WikiGenes - Universities