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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Buchnera

  • The genomic organization of the Buchnera groE operon is similar to that of the groE operon of E. coli except that a constitutive promoter sequence could not be identified; only the heat shock promoter was present [1].
  • Molecular characterization of the leucine cluster in Buchnera sp. strain PSY, a primary endosymbiont of the aphid Pemphigus spyrothecae [2].

High impact information on Buchnera

  • Genetic and physiological studies indicate that Buchnera can synthesize methionine, cysteine, and tryptophan and supply these amino acids to the aphid host [3].
  • In the case of some fast-growing species of aphids, the overproduction of tryptophan by Buchnera involves plasmid-amplification of the gene coding for anthranilate synthase, the first enzyme of the tryptophan biosynthetic pathway [3].
  • One exception to the overall lack of bias is groEL, which is known to be constitutively overexpressed in Buchnera and other endosymbionts [4].
  • To gain more knowledge of the nature of the association between PLRV and Buchnera GroEL, the groE operon of the primary endosymbiont of M. persicae (MpB groE) and its flanking sequences were characterized and the PLRV-binding domain of Buchnera GroEL was identified by deletion mutant analysis [1].
  • The gene encoding elongation factor Tu (tuf) in aphid endosymbionts (genus Buchnera) evolves at rates of 1.3 x 10(-10) to 2.5 x 10(-10) nonsynonymous substitutions and 3.9 x 10(-9) to 8.0 x 10(-9) synonymous substitutions per position per year [5].

Chemical compound and disease context of Buchnera

  • The spermidine content of Buchnera was considerably higher in young aphids and tended to decrease with the age of the host [6].
  • Prephenate dehydratase from the aphid endosymbiont (Buchnera) displays changes in the regulatory domain that suggest its desensitization to inhibition by phenylalanine [7].
  • Second, the regulatory domain of the Buchnera prephenate dehydratase shows changes in the ESRP sequence, which is involved in the allosteric binding of phenylalanine and is strongly conserved in prephenate dehydratase proteins from practically all known organisms [7].
  • Aphids experimentally deprived of Buchnera did not synthesize essential amino acids from dietary glutamic acid [8].
  • Incorporation into isoleucine was significantly elevated by the omission of dietary isoleucine, indicating that dietary supply may affect the biosynthetic rates of certain amino acids by Buchnera [8].

Biological context of Buchnera


Anatomical context of Buchnera

  • The data of principal interest was NOS presence in bacteriocytes, cells that host symbiotic prokaryotes belonging to the species Buchnera aphidicola, and in nuclei of adipocytes and gut cells [13].

Gene context of Buchnera


  1. Potato leafroll virus binds to the equatorial domain of the aphid endosymbiotic GroEL homolog. Hogenhout, S.A., van der Wilk, F., Verbeek, M., Goldbach, R.W., van den Heuvel, J.F. J. Virol. (1998) [Pubmed]
  2. Molecular characterization of the leucine cluster in Buchnera sp. strain PSY, a primary endosymbiont of the aphid Pemphigus spyrothecae. Sabater-Muñoz, B., Gómez-Valero, L., van Ham, R.C., Silva, F.J., Latorre, A. Appl. Environ. Microbiol. (2002) [Pubmed]
  3. Genetics, physiology, and evolutionary relationships of the genus Buchnera: intracellular symbionts of aphids. Baumann, P., Baumann, L., Lai, C.Y., Rouhbakhsh, D., Moran, N.A., Clark, M.A. Annu. Rev. Microbiol. (1995) [Pubmed]
  4. Evidence for genetic drift in endosymbionts (Buchnera): analyses of protein-coding genes. Wernegreen, J.J., Moran, N.A. Mol. Biol. Evol. (1999) [Pubmed]
  5. Evolutionary rates for tuf genes in endosymbionts of aphids. Brynnel, E.U., Kurland, C.G., Moran, N.A., Andersson, S.G. Mol. Biol. Evol. (1998) [Pubmed]
  6. Polyamine composition and expression of genes related to polyamine biosynthesis in an aphid endosymbiont, Buchnera. Nakabachi, A., Ishikawa, H. Appl. Environ. Microbiol. (2000) [Pubmed]
  7. Prephenate dehydratase from the aphid endosymbiont (Buchnera) displays changes in the regulatory domain that suggest its desensitization to inhibition by phenylalanine. Jiménez, N., González-Candelas, F., Silva, F.J. J. Bacteriol. (2000) [Pubmed]
  8. Quantifying nutrient production by the microbial symbionts in an aphid. Douglas, A.E., Minto, L.B., Wilkinson, T.L. J. Exp. Biol. (2001) [Pubmed]
  9. The tryptophan biosynthetic pathway of aphid endosymbionts (Buchnera): genetics and evolution of plasmid-associated anthranilate synthase (trpEG) within the aphididae. Rouhbakhsh, D., Lai, C.Y., von Dohlen, C.D., Clark, M.A., Baumann, L., Baumann, P., Moran, N.A., Voegtlin, D.J. J. Mol. Evol. (1996) [Pubmed]
  10. A conservative test of genetic drift in the endosymbiotic bacterium Buchnera: slightly deleterious mutations in the chaperonin groEL. Herbeck, J.T., Funk, D.J., Degnan, P.H., Wernegreen, J.J. Genetics (2003) [Pubmed]
  11. Putative evolutionary origin of plasmids carrying the genes involved in leucine biosynthesis in Buchnera aphidicola (endosymbiont of aphids). van Ham, R.C., Moya, A., Latorre, A. J. Bacteriol. (1997) [Pubmed]
  12. Evolution of the leucine gene cluster in Buchnera aphidicola: insights from chromosomal versions of the cluster. Sabater-Muñoz, B., van Ham, R.C., Moya, A., Silva, F.J., Latorre, A. J. Bacteriol. (2004) [Pubmed]
  13. Occurrence of nitric oxide synthase in Megoura viciae Buckton (Homoptera, Aphididae): an histochemical and immunohistochemical localisation. Ganassi, S., Tagliazucchi, D., Mola, L. European journal of histochemistry : EJH. (2005) [Pubmed]
  14. Structure and evolution of the leucine plasmids carried by the endosymbiont (Buchnera aphidicola) from aphids of the family Aphididae. Silva, F.J., van Ham, R.C., Sabater, B., Latorre, A. FEMS Microbiol. Lett. (1998) [Pubmed]
  15. Sequence analysis of a 34.7-kb DNA segment from the genome of Buchnera aphidicola (endosymbiont of aphids) containing groEL, dnaA, the atp operon, gidA, and rho. Clark, M.A., Baumann, L., Baumann, P. Curr. Microbiol. (1998) [Pubmed]
  16. Structure of the dnaA region of the endosymbiont, Buchnera aphidicola, of aphid Schizaphis graminum. Hassan, A.K., Moriya, S., Baumann, P., Yoshikawa, H., Ogasawara, N. DNA Res. (1996) [Pubmed]
  17. Structure and expression of the dnaKJ operon of Buchnera, an intracellular symbiotic bacteria of aphid. Sato, S., Ishikawa, H. J. Biochem. (1997) [Pubmed]
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