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Disease relevance of Bupleurum


High impact information on Bupleurum

  • 1. The mechanisms involved in the apoptotic effect of saikosaponin-d, a triterpene saponin from Bupleurum falcatum L., were studied in human CEM lymphocytes and compared with those of dexamethasone (3 x 10(-7) M) [4].
  • Bupleuran 2IIc, a pectic polysaccharide isolated from the roots of Bupleurum falcatum L., was characterized as a T-cell-independent B cell mitogen, that activates, proliferates and differentiates B cells in vivo and in vitro (Immunology 97 (1999) 540) [5].
  • B-cell proliferation activity of pectic polysaccharide from a medicinal herb, the roots of Bupleurum falcatum L. and its structural requirement [6].
  • Therefore, SS-d is believed to have an important role both in saiko agent-induced CRF release and CRF gene expression in the hypothalamus [7].
  • We examined the immunoregulatory action of saikosaponin-d (SSd), which was isolated from the root of Bupleurum talcatum L. and had a steroid-like structure, on murine thymocytes, and compared the action with that on spleen cells [8].

Biological context of Bupleurum


Anatomical context of Bupleurum


Associations of Bupleurum with chemical compounds

  • A water-soluble crude polysaccharide fraction (BR-1) prepared from the root of Bupleurum falcatum L [11].
  • The effects of saikosaponin-d extracted from the roots of Bupleurum falcatum L. on carbon tetrachloride-induced hepatic injury were studied in rats [12].
  • Unusual component sugars such as 2-methylfucose (2-Me-Fuc), 2-methylxylose (2-Me-Xyl), apiose (Api), and aceric acid (AceA) are contained in the bioactive pectins from Bupleurum falcatum, Glycyrrhiza uralensis, and Angelica acutiloba, but not in the other bioactive pectic heteroglycans and arabinogalactans from Chinese and Japanese herbs tested [13].
  • Triterpenoid saponins from Bupleurum smithii var. parvifolium [14].
  • More importantly, CHEMS did not interact with saikosaponin-d (SSD), a triterpene saponin from Bupleurum species, unlike CHOL [15].

Gene context of Bupleurum


Analytical, diagnostic and therapeutic context of Bupleurum

  • These Kampo medicines are classified into two categories; eight prescriptions containing Bupleurum root (Bupleurum falcatum L.) such as Sho-saiko-to and Saiko-keishi-to, and eight prescriptions not containing Bupleurum root such as Juzen-taiho-to and Ninjin-yoei-to [18].


  1. Effects of saikosaponin-d on aminonucleoside nephrosis in rats. Abe, H., Orita, M., Konishi, H., Arichi, S., Odashima, S. Eur. J. Pharmacol. (1986) [Pubmed]
  2. Effects of a polysaccharide fraction from the roots of Bupleurum falcatum L. on experimental gastric ulcer models in rats and mice. Sun, X.B., Matsumoto, T., Yamada, H. J. Pharm. Pharmacol. (1991) [Pubmed]
  3. Antiproliferative constituents from Umbelliferae plants VI. New ursane-type saikosaponin analogs from the fruits of Bupleurum rotundifolium. Fujioka, T., Yoshida, K., Fujii, H., Nagao, T., Okabe, H., Mihashi, K. Chem. Pharm. Bull. (2003) [Pubmed]
  4. Effect of saikosaponin, a triterpene saponin, on apoptosis in lymphocytes: association with c-myc, p53, and bcl-2 mRNA. Hsu, M.J., Cheng, J.S., Huang, H.C. Br. J. Pharmacol. (2000) [Pubmed]
  5. Induction of cell cycle regulatory proteins by murine B cell proliferating pectic polysaccharide from the roots of Bupleurum falcatum L. Matsumoto, T., Guo, Y.J., Ikejima, T., Yamada, H. Immunol. Lett. (2003) [Pubmed]
  6. B-cell proliferation activity of pectic polysaccharide from a medicinal herb, the roots of Bupleurum falcatum L. and its structural requirement. Sakurai, M.H., Matsumoto, T., Kiyohara, H., Yamada, H. Immunology (1999) [Pubmed]
  7. Central administration of saikosaponin-d increases corticotropin-releasing factor mRNA levels in the rat hypothalamus. Dobashi, I., Tozawa, F., Horiba, N., Sakai, Y., Sakai, K., Suda, T. Neurosci. Lett. (1995) [Pubmed]
  8. Cell type-oriented differential modulatory actions of saikosaponin-d on growth responses and DNA fragmentation of lymphocytes triggered by receptor-mediated and receptor-bypassed pathways. Kato, M., Pu, M.Y., Isobe, K., Hattori, T., Yanagita, N., Nakashima, I. Immunopharmacology (1995) [Pubmed]
  9. A possible signal transduction pathway for cyclin D2 expression by a pectic polysaccharide from the roots of bupleurum falcatum L. in murine B cell. Matsumoto, T., Hosono-Nishiyama, K., Guo, Y.J., Ikejima, T., Yamada, H. Int. Immunopharmacol. (2005) [Pubmed]
  10. Regulation of immune complexes binding of macrophages by pectic polysaccharide from Bupleurum falcatum L.: pharmacological evidence for the requirement of intracellular calcium/calmodulin on Fc receptor up-regulation by bupleuran 2IIb. Matsumoto, T., Yamada, H. J. Pharm. Pharmacol. (1995) [Pubmed]
  11. Purification of anti-ulcer polysaccharides from the roots of Bupleurum falcatum. Yamada, H., Sun, X.B., Matsumoto, T., Ra, K.S., Hirano, M., Kiyohara, H. Planta Med. (1991) [Pubmed]
  12. Protective effect of saikosaponin-d isolated from Bupleurum falcatum L. on CCl4-induced liver injury in the rat. Abe, H., Sakaguchi, M., Odashima, S., Arichi, S. Naunyn Schmiedebergs Arch. Pharmacol. (1982) [Pubmed]
  13. Existence of a rhamnogalacturonan II-like region in bioactive pectins from medicinal herbs. Hirano, M., Kiyohara, H., Yamada, H. Planta Med. (1994) [Pubmed]
  14. Triterpenoid saponins from Bupleurum smithii var. parvifolium. Zhao, Y.Y., Luo, H.S., Wang, B., Ma, L.B., Tu, G.Z., Zhang, R.Y. Phytochemistry (1996) [Pubmed]
  15. Cholesteryl hemisuccinate as a membrane stabilizer in dipalmitoylphosphatidylcholine liposomes containing saikosaponin-d. Ding, W.X., Qi, X.R., Li, P., Maitani, Y., Nagai, T. International journal of pharmaceutics. (2005) [Pubmed]
  16. Dual inhibition of cyclooxygenase-1 and 5-lipoxygenase by aerial part of Bupleurum fruticescens methanol extract. Prieto, J.M., Giner, R.M., Recio, M.C., Máñez, S., Ríos, J.L. Fitoterapia (2004) [Pubmed]
  17. Analysis of mitogenic substances in Bupleurum chinense by ESR spectroscopy. Ohtsu, S., Izumi, S., Iwanaga, S., Ohno, N., Yadomae, T. Biol. Pharm. Bull. (1997) [Pubmed]
  18. Toxicological aspects of Kampo medicines in clinical use. Ikegami, F., Fujii, Y., Ishihara, K., Satoh, T. Chem. Biol. Interact. (2003) [Pubmed]
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