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Gene Review

LCH  -  Lentil agglutinin-binding

Homo sapiens

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Disease relevance of LCH


Psychiatry related information on LCH

  • The etiology of LCH remains unknown, although the evidence indicates that it is a clonal proliferative disorder of Langerhans cells, it has also been characterized as reactive disorder, neoplastic process and a berrant immune response [5].
  • Among those trying to control weight, a significantly higher proportion of current LCHP diet users reported eating fewer calories and meeting physical activity recommendations (38.0%) compared with nonusers (29.8%) [6].

High impact information on LCH

  • Finally, LCH granulomas were the only site where CD154-positive T cells could be identified in close contact with LC intensely expressing CD40 Ags [1].
  • Taken together, these results strongly support the idea that an abnormal immune response initiated by LC may participate in the pathogenesis of pulmonary LCH, and suggest that therapeutic strategies aimed at modifying the lymphostimulatory phenotype of LC may be useful in the treatment of this disorder [1].
  • For R = tBu, the ionic carbenium thiocyanates [LCH]+ SCN- dominate the product spectrum and the respective thioureas are obtained in low yield [7].
  • The left kidney of a rat was perfused either with 200 micrograms of Lens culinaris hemagglutinin (LCH) plus 1 mg of 6D1 (IgG1 fraction) (Group I and III) or with LCH only (Group II) through a cannula placed in the left renal artery [8].
  • The first major stride toward understanding LCH was taken when ultrastructural studies identified the proliferating cells as part of the Langerhans (dendritic) cell system [9].

Chemical compound and disease context of LCH

  • Etoposide should be seriously considered as therapy for patients with LCH in whom the toxicity/benefit ratio of steroid therapy is unacceptably high [10].

Biological context of LCH


Anatomical context of LCH

  • Moreover, the agreement concerning diagnostic criteria provides a solid foundation for current clinical trials and for laboratory research regarding the possible roles of the immune system, clonality, and cytokines in the etiology of LCH [9].
  • Descriptions of patients with LCH whose disease is confined to lymph nodes are rare [16].
  • At term, type a of Con A, type C of LCH and types Y and Z of PHA-E were the main subfractions in amniotic fluid, assumed to be produced by the fetal liver [13].
  • With combined use of concanavalin A (Con A) and lentil agglutinin (LCH) binding tests, AFPs were classified into three subtypes: benign hepatic condition type (six patients), hepatocellular carcinoma type (nine patients) and yolk sac type (12 patients) [17].
  • The mean initial leukocyte count was higher than in the non-HLH/LCH group (270,700 +/- 60,677 microl(-1) vs 134,141 +/- 5,663 microl(-1); p = 0.074) [18].

Associations of LCH with chemical compounds

  • Concanavalin A (Con A) and agglutinins from the pea (PSA), lentil (LCH), and fava bean (VFA) constitute a group of D-mannose/D-glucose binding legume lectins [11].
  • The hapten inhibition assay results reveal that the presence of a methyl or methylene group at the O-2 or O-3 position of the sugar is essential for hydrophobic interaction with PSA, LCH, and VFA [11].
  • Etoposide may become a "first-line" drug in the treatment of systemic LCH, especially when the side effects of steroid therapy are considered unacceptable [19].
  • Comparison of the hydrolysis of polyethylene terephthalate fibers by a hydrolase from Fusarium oxysporum LCH I and Fusarium solani f. sp. pisi [20].
  • The hydrolase from a newly isolated Fusarium oxysporum strain (LCH 1) was more efficient in releasing terephthalic acid from PET fibers compared to the enzyme from F. solani f. sp. pisi DSM 62420 when equal amounts of p-nitrophenyl butyrate-hydrolyzing activity were employed [20].

Regulatory relationships of LCH


Other interactions of LCH


Analytical, diagnostic and therapeutic context of LCH


  1. Evidence that Langerhans cells in adult pulmonary Langerhans cell histiocytosis are mature dendritic cells: importance of the cytokine microenvironment. Tazi, A., Moreau, J., Bergeron, A., Dominique, S., Hance, A.J., Soler, P. J. Immunol. (1999) [Pubmed]
  2. Is high-resolution computed tomography a reliable tool to predict the histopathological activity of pulmonary Langerhans cell histiocytosis? Soler, P., Bergeron, A., Kambouchner, M., Groussard, O., Brauner, M., Grenier, P., Crestani, B., Mal, H., Tazi, A., Battesti, J.P., Loiseau, P., Valeyre, D. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  3. Liver transplantation in Langerhans' cell histiocytosis (histiocytosis X). Concepcion, W., Esquivel, C.O., Terry, A., Nakazato, P., Garcia-Kennedy, R., Houssin, D., Cox, K.L. Semin. Oncol. (1991) [Pubmed]
  4. Need for a cooperative study: Pulmonary Langerhans cell histiocytosis and its management in adults. McClain, K.L., Gonzalez, J.M., Jonkers, R., De Juli, E., Egeler, M. Med. Pediatr. Oncol. (2002) [Pubmed]
  5. Unusual location of eosinophilic granuloma. Haouimi, A.S., Al-Hawsawi, Z.M., Jameel, A.N. Saudi medical journal. (2004) [Pubmed]
  6. Use of low-carbohydrate, high-protein diets among americans: correlates, duration, and weight loss. Blanck, H.M., Gillespie, C., Serdula, M.K., Khan, L.K., Galusk, D.A., Ainsworth, B.E. MedGenMed [electronic resource] : Medscape general medicine. (2006) [Pubmed]
  7. C-H activation with elemental sulfur: synthesis of cyclic thioureas from formaldehyde aminals and S8. Denk, M.K., Gupta, S., Brownie, J., Tajammul, S., Lough, A.J. Chemistry (Weinheim an der Bergstrasse, Germany) (2001) [Pubmed]
  8. Role of CD59 in experimental glomerulonephritis in rats. Matsuo, S., Nishikage, H., Yoshida, F., Nomura, A., Piddlesden, S.J., Morgan, B.P. Kidney Int. (1994) [Pubmed]
  9. Langerhans cell histiocytosis. Egeler, R.M., D'Angio, G.J. J. Pediatr. (1995) [Pubmed]
  10. Etoposide (VP16) in the treatment of multisystem Langerhans cell histiocytosis (histiocytosis X). Broadbent, V., Pritchard, J., Yeomans, E. Med. Pediatr. Oncol. (1989) [Pubmed]
  11. Synthesis of high-affinity, hydrophobic monosaccharide derivatives and study of their interaction with concanavalin A, the pea, the lentil, and fava bean lectins. Loganathan, D., Osborne, S.E., Glick, G.D., Goldstein, I.J. Arch. Biochem. Biophys. (1992) [Pubmed]
  12. Leydig cell hypoplasia: cases with new mutations, new polymorphisms and cases without mutations in the luteinizing hormone receptor gene. Richter-Unruh, A., Martens, J.W., Verhoef-Post, M., Wessels, H.T., Kors, W.A., Sinnecker, G.H., Boehmer, A., Drop, S.L., Toledo, S.P., Brunner, H.G., Themmen, A.P. Clin. Endocrinol. (Oxf) (2002) [Pubmed]
  13. Alpha-fetoprotein subfractions in amniotic fluid identified by a modification of the method of concanavalin A, lentil lectin or phytohemagglutinin-E affinity crossed-line immunoelectrophoresis. Ishiguro, T., Sakaguchi, H., Fukui, M., Sugitachi, I. Tumour Biol. (1985) [Pubmed]
  14. A novel missense homozygous inactivating mutation in the fourth transmembrane helix of the luteinizing hormone receptor in leydig cell hypoplasia. Leung, M.Y., Al-Muslim, O., Wu, S.M., Aziz, A., Inam, S., Awadh, M., Rennert, O.M., Chan, W.Y. Am. J. Med. Genet. A (2004) [Pubmed]
  15. Serum alpha-fetoprotein subfractions in pregnant women identified by the modified method of lectin affinity crossed-line immunoelectrophoresis. Ishiguro, T., Sakaguchi, H., Fukui, M., Sugitachi, I. Biological research in pregnancy and perinatology. (1985) [Pubmed]
  16. Fine needle aspiration cytology of Langerhans cell histiocytosis confined to lymph nodes. A case report. Lee, J.S., Lee, M.C., Park, C.S., Juhng, S.W. Acta Cytol. (1997) [Pubmed]
  17. Three different types of alpha-fetoprotein in the diagnosis of malignant solid tumors: use of a sensitive lectin-affinity immunoelectrophoresis. Tsuchida, Y., Kaneko, M., Fukui, M., Sakaguchi, H., Ishiguro, T. J. Pediatr. Surg. (1989) [Pubmed]
  18. Histiocytosis following T-acute lymphoblastic leukemia: a BFM study. Trebo, M.M., Attarbaschi, A., Mann, G., Minkov, M., Kornmüller, R., Gadner, H. Leuk. Lymphoma (2005) [Pubmed]
  19. Etoposide in the treatment of six children with Langerhans cell histiocytosis (histiocytosis X). Viana, M.B., Oliveira, B.M., Silva, C.M., Rios Leite, V.H. Med. Pediatr. Oncol. (1991) [Pubmed]
  20. Comparison of the hydrolysis of polyethylene terephthalate fibers by a hydrolase from Fusarium oxysporum LCH I and Fusarium solani f. sp. pisi. Nimchua, T., Punnapayak, H., Zimmermann, W. Biotechnology journal (2007) [Pubmed]
  21. Langerin (CD207) staining in normal pediatric tissues, reactive lymph nodes, and childhood histiocytic disorders. Chikwava, K., Jaffe, R. Pediatr. Dev. Pathol. (2004) [Pubmed]
  22. Langerhans cells in Langerhans cell histiocytosis and peripheral adenocarcinomas of the lung. Colasante, A., Poletti, V., Rosini, S., Ferracini, R., Musiani, P. Am. Rev. Respir. Dis. (1993) [Pubmed]
  23. Serum alpha-fetoprotein subfractions in patients with primary hepatoma or hepatic metastasis of gastric cancer. Ishiguro, T., Sugitachi, I., Sakaguchi, H., Itani, S. Cancer (1985) [Pubmed]
  24. Clinical and epidemiologic studies of familial hemophagocytic lymphohistiocytosis in Japan. Japan LCH Study Group. Ishii, E., Ohga, S., Tanimura, M., Imashuku, S., Sako, M., Mizutani, S., Miyazaki, S. Med. Pediatr. Oncol. (1998) [Pubmed]
  25. Lectin-binding characteristics of Wuchereria bancrofti microfilariae. Rao, U.R., Chandrashekar, R., Parab, P.B., Rajasekariah, G.R., Subrahmanyam, D. Acta Trop. (1987) [Pubmed]
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