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Chemical Compound Review

CID6327012     bismuth; 2-hydroxybenzoic acid; hydrate

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Disease relevance of o-hydroxybenzoic acid


High impact information on o-hydroxybenzoic acid


Chemical compound and disease context of o-hydroxybenzoic acid


Biological context of o-hydroxybenzoic acid


Anatomical context of o-hydroxybenzoic acid


Associations of o-hydroxybenzoic acid with other chemical compounds


Gene context of o-hydroxybenzoic acid

  • RBC also may be substituted for bismuth subsalicylate and an + H2-receptor antagonist in standard bismuth-based triple therapy [29].
  • In ultrastructural studies 30-90 min after single oral doses of CBS or bismuth subsalicylate, CP had detached from the gastric epithelial cells and exhibited structural degradation associated with the selective deposition of a particulate bismuth complex within and upon the surface of the organisms [30].
  • Decreased guaiac test sensitivity was associated with activated charcoal, dimethylaminoethanol, red chile, N-acetylcysteine, rifampin, red Jell-O (General Foods Corp, White Plains, NY), orange juice, Pepto-Bismol (Norwich Eaton Pharmaceuticals, Norwich, NY), simethicone, spaghetti sauce, and several red wines [31].

Analytical, diagnostic and therapeutic context of o-hydroxybenzoic acid


  1. A controlled trial of bismuth subsalicylate in infants with acute watery diarrheal disease. Figueroa-Quintanilla, D., Salazar-Lindo, E., Sack, R.B., León-Barúa, R., Sarabia-Arce, S., Campos-Sánchez, M., Eyzaguirre-Maccan, E. N. Engl. J. Med. (1993) [Pubmed]
  2. Comparison of loperamide with bismuth subsalicylate for the treatment of acute travelers' diarrhea. Johnson, P.C., Ericsson, C.D., DuPont, H.L., Morgan, D.R., Bitsura, J.A., Wood, L.V. JAMA (1986) [Pubmed]
  3. Prevention of travelers' diarrhea by the tablet formulation of bismuth subsalicylate. DuPont, H.L., Ericsson, C.D., Johnson, P.C., Bitsura, J.A., DuPont, M.W., de la Cabada, F.J. JAMA (1987) [Pubmed]
  4. Efficacy of open-label bismuth subsalicylate for the treatment of microscopic colitis. Fine, K.D., Lee, E.L. Gastroenterology (1998) [Pubmed]
  5. Bismuth therapy in gastrointestinal diseases. Gorbach, S.L. Gastroenterology (1990) [Pubmed]
  6. Treatment of Helicobacter pylori infection in rhesus monkeys using a novel antiadhesion compound. Mysore, J.V., Wigginton, T., Simon, P.M., Zopf, D., Heman-Ackah, L.M., Dubois, A. Gastroenterology (1999) [Pubmed]
  7. Bismuth subsalicylate markedly decreases hydrogen sulfide release in the human colon. Suarez, F.L., Furne, J.K., Springfield, J., Levitt, M.D. Gastroenterology (1998) [Pubmed]
  8. Bismuth subsalicylate therapy of viral gastroenteritis. Steinhoff, M.C., Douglas, R.G., Greenberg, H.B., Callahan, D.R. Gastroenterology (1980) [Pubmed]
  9. Symptomatic treatment of diarrhea with bismuth subsalicylate among students attending a Mexican university. DuPont, H.L., Sullivan, P., Pickering, L.K., Haynes, G., Ackerman, P.B. Gastroenterology (1977) [Pubmed]
  10. Protective effect of Pepto-Bismol liquid on the gastric mucosa of rats. Goldenberg, M.M., Honkomp, L.J., Burrous, S.E., Castellion, A.W. Gastroenterology (1975) [Pubmed]
  11. Interaction of bismuth subsalicylate with fruit juices, ascorbic acid, and thiol-containing substrates to produce soluble bismuth products active against Clostridium difficile. Mahony, D.E., Woods, A., Eelman, M.D., Burford, N., Veldhuyzen van Zanten, S.J. Antimicrob. Agents Chemother. (2005) [Pubmed]
  12. Treatment of Campylobacter pylori does not alter gastric acid secretion. Montbriand, J.R., Appelman, H.D., Cotner, E.K., Nostrant, T.T., Elta, G.H. Am. J. Gastroenterol. (1989) [Pubmed]
  13. 14C-urea breath test for the detection of Helicobacter pylori. Veldhuyzen van Zanten, S.J., Tytgat, K.M., Hollingsworth, J., Jalali, S., Rshid, F.A., Bowen, B.M., Goldie, J., Goodacre, R.L., Riddell, R.H., Hunt, R.H. Am. J. Gastroenterol. (1990) [Pubmed]
  14. Reduction of capsular polysaccharide and potentiation of aminoglycoside inhibition in gram-negative bacteria by bismuth subsalicylate. Domenico, P., Landolphi, D.R., Cunha, B.A. J. Antimicrob. Chemother. (1991) [Pubmed]
  15. Simple noninvasive method to test efficacy of drugs in the eradication of Helicobacter pylori infection: the example of combined bismuth subsalicylate and nitrofurantoin. Graham, D.Y., Klein, P.D., Evans, D.G., Evans, D.J., Alpert, L.C., Opekun, A., Jerdack, G.R., Morgan, D.R. Am. J. Gastroenterol. (1991) [Pubmed]
  16. Effect of bismuth subsalicylate on ciprofloxacin bioavailability. Rambout, L., Sahai, J., Gallicano, K., Oliveras, L., Garber, G. Antimicrob. Agents Chemother. (1994) [Pubmed]
  17. Metabolism of bismuth subsalicylate and intracellular accumulation of bismuth by Fusarium sp. strain BI. Dodge, A.G., Wackett, L.P. Appl. Environ. Microbiol. (2005) [Pubmed]
  18. Cytoprotective effect of bismuth subsalicylate in indomethacin-treated rats is associated with enhanced mucus bismuth concentration. Tanaka, S., Guth, P.H., Carryl, O.R., Kaunitz, J.D. Aliment. Pharmacol. Ther. (1997) [Pubmed]
  19. Effect of bismuth salts on systemic and mucosal immune responses to orally administered cholera toxin. Horowitz, N.S., Staats, H.F., Palker, T.J. Immunopharmacology (1995) [Pubmed]
  20. Bismuth subsalicylate reduces peptic injury of the oesophagus in rabbits. Tay, H.P., Chaparala, R.C., Harmon, J.W., Huesken, J., Saini, N., Hakki, F.Z., Schweitzer, E.J. Gut (1990) [Pubmed]
  21. Bismuth subsalicylate in the cecum. Hellmig, S., Stüber, E., Katsoulis, S., Fölsch, U.R. Gastrointest. Endosc. (2002) [Pubmed]
  22. Acalculous cholecystitis and septicemia caused by non-O1 Vibrio cholerae: first reported case and review of biliary infections with Vibrio cholerae. West, B.C., Silberman, R., Otterson, W.N. Diagn. Microbiol. Infect. Dis. (1998) [Pubmed]
  23. Bismuth subsalicylate increases intracellular Ca2+, MAP-kinase activity, and cell proliferation in normal human gastric mucous epithelial cells. Gilster, J., Bacon, K., Marlink, K., Sheppard, B., Deveney, C., Rutten, M. Dig. Dis. Sci. (2004) [Pubmed]
  24. Eradication of Helicobacter mustelae from the ferret stomach: an animal model of Helicobacter (Campylobacter) pylori chemotherapy. Otto, G., Fox, J.G., Wu, P.Y., Taylor, N.S. Antimicrob. Agents Chemother. (1990) [Pubmed]
  25. A practical guide to the management of distal ulcerative colitis. Ardizzone, S., Porro, G.B. Drugs (1998) [Pubmed]
  26. Systematic review: microscopic colitis. Nyhlin, N., Bohr, J., Eriksson, S., Tysk, C. Aliment. Pharmacol. Ther. (2006) [Pubmed]
  27. Decreased tetracycline bioavailability caused by a bismuth subsalicylate antidiarrheal mixture. Albert, K.S., Welch, R.D., DeSante, K.A., DiSanto, A.R. Journal of pharmaceutical sciences. (1979) [Pubmed]
  28. Natural and experimental Helicobacter mustelae reinfection following successful antimicrobial eradication in ferrets. Batchelder, M., Fox, J.G., Hayward, A., Yan, L., Shames, B., Murphy, J.C., Palley, L. Helicobacter (1996) [Pubmed]
  29. Randomized comparison of ranitidine bismuth citrate-based triple therapies for Helicobacter pylori. Laine, L., Estrada, R., Trujillo, M., Emami, S. Am. J. Gastroenterol. (1997) [Pubmed]
  30. Antibacterial action of bismuth in relation to Campylobacter pyloridis colonization and gastritis. Marshall, B.J., Armstrong, J.A., Francis, G.J., Nokes, N.T., Wee, S.H. Digestion (1987) [Pubmed]
  31. Substances that interfere with guaiac card tests: implications for gastric aspirate testing. Gogel, H.K., Tandberg, D., Strickland, R.G. The American journal of emergency medicine. (1989) [Pubmed]
  32. Evaluation of bismuth subsalicylate in relieving symptoms of indigestion. Hailey, F.J., Newsom, J.H. Arch. Intern. Med. (1984) [Pubmed]
  33. Prevention of traveler's diarrhea by the tablet form of bismuth subsalicylate. Steffen, R., DuPont, H.L., Heusser, R., Helminger, A., Witassek, F., Manhart, M.D., Schär, M. Antimicrob. Agents Chemother. (1986) [Pubmed]
  34. [13C]urea breath test to confirm eradication of Helicobacter pylori. Slomianski, A., Schubert, T., Cutler, A.F. Am. J. Gastroenterol. (1995) [Pubmed]
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