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MeSH Review

Sarcoma Virus, Woolly Monkey

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Disease relevance of Sarcoma Virus, Woolly Monkey

  • It has recently been reported that the sequences of the sis oncogene of simian sarcoma virus (SSV) and of human platelet-derived growth factor (PDGF) are very similar, establishing the most solid link yet between the mitogenic actions of growth factors and the transforming proteins of retroviruses [1].
  • A clue to the molecular mechanism of neoplastic transformation was provided by the finding of a near identity in amino-acid sequence between the platelet-derived growth factor (PDGF) B-chain and a region in the transforming protein, p28sis, of simian sarcoma virus (SSV), an agent that causes sarcomas and gliomas in experimental animals [2].
  • Three antisera against RD114 p30 gave similar positive results, while two antisera prepared against simian sarcoma virus p30, one antiserum prepared against murine leukemia virus p30, and one antiserum prepared against feline leukemia virus p30 gave no immunofluorescence [3].
  • Synthesis of a PDGF-like growth factor in human glioma and sarcoma cells suggests the expression of the cellular homologue to the transforming protein of simian sarcoma virus [4].
  • Purified RNA-directed DNA polymerase had the same primer-template characteristics, sedimentation properties, and immunological cross reactivity as the enzyme purified from density gradient-banded virions of simian sarcoma virus [5].

High impact information on Sarcoma Virus, Woolly Monkey


Chemical compound and disease context of Sarcoma Virus, Woolly Monkey


Biological context of Sarcoma Virus, Woolly Monkey


Gene context of Sarcoma Virus, Woolly Monkey


Analytical, diagnostic and therapeutic context of Sarcoma Virus, Woolly Monkey


  1. Antisera to a synthetic peptide of the sis viral oncogene product recognize human platelet-derived growth factor. Niman, H.L. Nature (1984) [Pubmed]
  2. Antibodies against platelet-derived growth factor inhibit acute transformation by simian sarcoma virus. Johnsson, A., Betsholtz, C., Heldin, C.H., Westermark, B. Nature (1985) [Pubmed]
  3. Expression of antigenic crossreactivity to RD114 p 30 protein in a human fibrosarcoma cell line. Smith, H.S., Riggs, J.L., Springer, E.L. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
  4. Synthesis of a PDGF-like growth factor in human glioma and sarcoma cells suggests the expression of the cellular homologue to the transforming protein of simian sarcoma virus. Betsholtz, C., Heldin, C.H., Nister, M., Ek, B., Wasteson, A., Westermark, B. Biochem. Biophys. Res. Commun. (1983) [Pubmed]
  5. A comparative evaluation of methods for isolation of RNA-directed DNA polymerase from cells in a reconstituted system. Allaudeen, H.S., Sarngadharan, M.G., Gallo, R.C. Biochim. Biophys. Acta (1976) [Pubmed]
  6. Nucleotide sequence analysis identifies the human c-sis proto-oncogene as a structural gene for platelet-derived growth factor. Chiu, I.M., Reddy, E.P., Givol, D., Robbins, K.C., Tronick, S.R., Aaronson, S.A. Cell (1984) [Pubmed]
  7. Transforming protein of simian sarcoma virus stimulates autocrine growth of SSV-transformed cells through PDGF cell-surface receptors. Huang, J.S., Huang, S.S., Deuel, T.F. Cell (1984) [Pubmed]
  8. Alternative RNA splicing affects function of encoded platelet-derived growth factor A chain. Collins, T., Bonthron, D.T., Orkin, S.H. Nature (1987) [Pubmed]
  9. Evidence that the v-sis gene product transforms by interaction with the receptor for platelet-derived growth factor. Leal, F., Williams, L.T., Robbins, K.C., Aaronson, S.A. Science (1985) [Pubmed]
  10. Human-proto-oncogene nucleotide sequences corresponding to the transforming region of simian sarcoma virus. Josephs, S.F., Guo, C., Ratner, L., Wong-Staal, F. Science (1984) [Pubmed]
  11. Inhibition of deoxynucleotide-polymerizing enzyme activities of human leukemia lymphoblasts and simian sarcoma virus by tilorone and thirteen of its analogs. DiCioccio, R.A., Sahai Srivastava, B.I. J. Natl. Cancer Inst. (1978) [Pubmed]
  12. Inhibition of deoxynucleotide-polymerizing enzyme activities of human cells and of simian sarcoma virus by heparin. DiCioccio, R.A., Srivastava, B.I. Cancer Res. (1978) [Pubmed]
  13. Compartmentalization of autocrine signal transduction pathways in Sis-transformed NIH 3T3 cells. Valgeirsdóttir, S., Eriksson, A., Nistér, M., Heldin, C.H., Westermark, B., Claesson-Welsh, L. J. Biol. Chem. (1995) [Pubmed]
  14. Simian sarcoma virus transformation-specific glycopeptide: immunological relationship to human platelet-derived growth factor. Thiel, H.J., Hafenrichter, R. Virology (1984) [Pubmed]
  15. Genetic mapping of the mouse proto-oncogene c-sis to chromosome 15. Kozak, C.A., Sears, J.F., Hoggan, M.D. Science (1983) [Pubmed]
  16. Amino acid sequence homology between protein products of oncogenes and hormones (v-myc--gastrin and oxytocin; v-sis--secretin). Korec, E., Hlozánek, I., Korcová, H., Simůnek, J. Folia Biol. (Praha) (1985) [Pubmed]
  17. Possible positive autocrine feedback in the prereplicative phase of human fibroblasts. Paulsson, Y., Hammacher, A., Heldin, C.H., Westermark, B. Nature (1987) [Pubmed]
  18. Polypeptide growth factors: roles in normal and abnormal cell growth. Deuel, T.F. Annu. Rev. Cell Biol. (1987) [Pubmed]
  19. Expression of v-src in mammary epithelial cells induces transcription via STAT3. Smith, P.D., Crompton, M.R. Biochem. J. (1998) [Pubmed]
  20. Basic fibroblast-like growth factor is present in the conditioned medium of simian sarcoma virus transformed NRK cells. Hicks, K., Friedman, B., Rosner, M.R. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
  21. Isolation of type C virions from a normal human fibroblast strain. Panem, S., Prochownik, E.V., Reale, F.R., Kirsten, W.H. Science (1975) [Pubmed]
  22. Detection of antibodies cross-reactive with type C RNA tumor viral p30 protein in human sera and exudate fluids. Herbrink, P., Moen, J.E., Brouwer, J., Warnaar, S.O. Cancer Res. (1980) [Pubmed]
  23. Immunochemical reactivity of simian sarcoma virus polypeptides isolated by preparative sodium dodecyl sulfate polyacrylamide gel electrophoresis. Johnson, J.C., Higuchi, T., Geissler, E. Can. J. Microbiol. (1981) [Pubmed]
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