The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Dermaton     2,4-dichloro-1-[(Z)-2-chloro- 1...

Synonyms: Apachlor, Enolofos, Haptarax, Haptasol, Sapecron, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Dermaton


Psychiatry related information on Dermaton


High impact information on Dermaton


Biological context of Dermaton


Anatomical context of Dermaton


Associations of Dermaton with other chemical compounds


Gene context of Dermaton

  • The enzyme is potently inhibited by OPs (ki [paraoxon] = 6.3 +/- 1.4 x 10(7)/M/min, ki [chlorfenvinphos] = 5.9 +/- 0.6 x 10(7)/M/min) and exhibits a high turnover of methylthiobutyrate (1009/s), consistent with its proposed homology to the ali-esterase that is thought to mutate to confer OP resistance in Musca domestica [24].
  • Earlier experiments have revealed that rats treated with a single dose of chlorphenvinphos (CVP), an irreversible acetylcholinesterase inhibitor, are hyposensitive to amphetamine (AMPH) given three weeks after CVP [25].
  • OBJECTIVES: Effects of acute exposure to organophosphorous pesticides (OPs), chlorphenvinphos (CVP) or chlorphyriphos (CPF) on amphetamine (AMPH)- or scopolamine (SCOP)-induced open-field locomotion were compared in rats [6].

Analytical, diagnostic and therapeutic context of Dermaton


  1. Detoxification of the organophosphorus insecticide chlorfenvinphos by rat, rabbit and human liver enzymes. Hutson, D.H., Logan, C.J. Xenobiotica (1986) [Pubmed]
  2. Effect of dimethoate and chlorfenvinphos on plasma membrane integrity of Synechocystis sp. PCC 6803. Mohapatra, P.K., Schiewer, U. Ecotoxicol. Environ. Saf. (1998) [Pubmed]
  3. Effect of chlorfenvinphos on rat liver subjected to ischemia and reperfusion. Kamiński, M., Wiaderkiewicz, R., Siekierska, E. Prz. Lek. (1997) [Pubmed]
  4. Dietary protein deficiency and the influence of chlorfenvinphos on the biological parameters in rats. Puzyńska, L. Die Nahrung. (1984) [Pubmed]
  5. Effect of some pesticides on the efficiency of the inoculated Rhizobium associated with broad bean plants. Salem, S.H., El-Bahrawy, S.A., Radwan, H. Zentralblatt für Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Zweite naturwissenschaftliche Abt.: Allgemeine, landwirtschaftliche und technische Mikrobiologie. (1976) [Pubmed]
  6. Amphetamine- and scopolamine-induced locomotor activity following treatment with chlorphenvinphos or chlorphyriphos in rats. Lutz, P., Gralewicz, S., Kur, B., Wiaderna, D. International journal of occupational medicine and environmental health. (2005) [Pubmed]
  7. Interaction of chlorphenvinphos with cholinergic receptors in the rabbit hypothalamus. Gralewicz, S., Tomas, T., Soćko, R. Neurotoxicology and teratology. (1995) [Pubmed]
  8. Short-term effects of Quirlan(R) (chlorfenvinphos) on the behavior and acetylcholinesterase activity of Gambusia holbrooki. Sismeiro-Vivas, J., Abrantes, N., Pereira, J.L., Castro, B.B., Gonçalves, F. Environ. Toxicol. (2007) [Pubmed]
  9. Identification of chlorfenvinphos toxicity in a municipal effluent in Sydney, New South Wales, Australia. Bailey, H.C., Elphick, J.R., Krassoi, R., Mulhall, A.M., Lovell, A.J., Slee, D.J. Environ. Toxicol. Chem. (2005) [Pubmed]
  10. Susceptibility of Amblyomma variegatum ticks to acaricides in Ghana. Natala, A.J., Agyei, A.D., Awumbila, B. Exp. Appl. Acarol. (2005) [Pubmed]
  11. Different inhalation lethality between micron-sized and submicron-sized aerosols of organophosphorus insecticide, chlorfenvinphos, in rats. Takahashi, H., Yoshida, M., Murao, N., Maita, K. Toxicol. Lett. (1994) [Pubmed]
  12. Effect of chlorfenvinphos, cypermethrin and their mixture on the intestinal transport of leucine and methionine. Sedrowicz, L., Witkowska, D., Oledzka, R. Journal of applied toxicology : JAT. (1996) [Pubmed]
  13. Integrated tick and tick-borne disease control trials in crossbred dairy cattle in Malawi. Lawrence, J.A., Musisi, F.L., Mfitilodze, M.W., Tjornehoj, K., Whiteland, A.P., Kafuwa, P.T., Chamambala, K.E. Tropical animal health and production. (1996) [Pubmed]
  14. A comparison of changes in spontaneous (EEG) and evoked brain activity induced by chlorphenvinphos and physostigmine in rats and rabbits. Tomas, T., Gralewicz, S. Polish journal of occupational medicine and environmental health. (1992) [Pubmed]
  15. Impaired respiratory muscle function in chemical plant workers producing chlorfenvinphos. Konieczny, B., Kossmann, S., Makuch, M. Annals of agricultural and environmental medicine : AAEM. (1999) [Pubmed]
  16. Influence of chlorfenvinphos and ipofos on oxido-reducing processes in the rat brain mitochondria during development. Skonieczna, M., Wierciak, M., Scisłlowska, I., Bicz, W. Neuropatologia polska. (1981) [Pubmed]
  17. Neurotoxicity of chlorphenvinphos an organophosphorus pesticide: effects on blood and brain cholinesterase activity, open field behavior and response-to-change in a "T" maze in rats. Soćko, R., Gralewicz, S., Górny, R. Polish journal of occupational medicine. (1989) [Pubmed]
  18. Peripheral blood in the Japanese quail (Coturnix coturnix japonica) in acute poisoning by different insecticides. Gromysz-Kałkowska, K., Szubartowska, E., Kaczanowska, E. Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. (1985) [Pubmed]
  19. Evaluation of organophosphorus pesticide residues in citrus fruits from the Valencian community (Spain). Torres, C.M., Picó, Y., Marín, R., Mañes, J. Journal of AOAC International. (1997) [Pubmed]
  20. Central cholinergic activation by chlorfenvinphos, and organophosphate, in the rat. Osumi, Y., Fujiwara, H., Oishi, R., Takaori, S. Jpn. J. Pharmacol. (1975) [Pubmed]
  21. Activity of certain enzymes and histomorphological changes in subacute intoxication of rats with selected organophosphates. Gajewski, D., Katkiewicz, M. Acta physiologica Polonica. (1981) [Pubmed]
  22. Bioconcentration of chlorpyrifos, chlorfenvinphos, and methidathion in Mytilus galloprovincialis. Serrano, R., López, F.J., Hernández, F., Peña, J.B. Bulletin of environmental contamination and toxicology. (1997) [Pubmed]
  23. Effects of single exposure to chlorphenvinphos, an organophosphate insecticide, on electrical activity (EEG) of the rat brain. Gralewicz, S., Tomas, T., Soćko, R. Polish journal of occupational medicine. (1989) [Pubmed]
  24. cDNA cloning, baculovirus-expression and kinetic properties of the esterase, E3, involved in organophosphorus resistance in Lucilia cuprina. Newcomb, R.D., Campbell, P.M., Russell, R.J., Oakeshott, J.G. Insect Biochem. Mol. Biol. (1997) [Pubmed]
  25. Behavioral sensitization to amphetamine induced by a single i.p. dose of oxotremorine in the rat. Gralewicz, S. Acta neurobiologiae experimentalis. (2002) [Pubmed]
  26. The effect of arsenical dips on Parafilaria bovicola in artificially infected cattle in South Africa. Nevill, E.M. Onderstepoort J. Vet. Res. (1985) [Pubmed]
WikiGenes - Universities