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Chemical Compound Review

Dermaton     2,4-dichloro-1-[(Z)-2-chloro- 1...

Synonyms: Apachlor, Enolofos, Haptarax, Haptasol, Sapecron, ...
 
 
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Disease relevance of Dermaton

 

Psychiatry related information on Dermaton

 

High impact information on Dermaton

 

Biological context of Dermaton

 

Anatomical context of Dermaton

 

Associations of Dermaton with other chemical compounds

 

Gene context of Dermaton

  • The enzyme is potently inhibited by OPs (ki [paraoxon] = 6.3 +/- 1.4 x 10(7)/M/min, ki [chlorfenvinphos] = 5.9 +/- 0.6 x 10(7)/M/min) and exhibits a high turnover of methylthiobutyrate (1009/s), consistent with its proposed homology to the ali-esterase that is thought to mutate to confer OP resistance in Musca domestica [24].
  • Earlier experiments have revealed that rats treated with a single dose of chlorphenvinphos (CVP), an irreversible acetylcholinesterase inhibitor, are hyposensitive to amphetamine (AMPH) given three weeks after CVP [25].
  • OBJECTIVES: Effects of acute exposure to organophosphorous pesticides (OPs), chlorphenvinphos (CVP) or chlorphyriphos (CPF) on amphetamine (AMPH)- or scopolamine (SCOP)-induced open-field locomotion were compared in rats [6].
 

Analytical, diagnostic and therapeutic context of Dermaton

References

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  2. Effect of dimethoate and chlorfenvinphos on plasma membrane integrity of Synechocystis sp. PCC 6803. Mohapatra, P.K., Schiewer, U. Ecotoxicol. Environ. Saf. (1998) [Pubmed]
  3. Effect of chlorfenvinphos on rat liver subjected to ischemia and reperfusion. Kamiński, M., Wiaderkiewicz, R., Siekierska, E. Prz. Lek. (1997) [Pubmed]
  4. Dietary protein deficiency and the influence of chlorfenvinphos on the biological parameters in rats. Puzyńska, L. Die Nahrung. (1984) [Pubmed]
  5. Effect of some pesticides on the efficiency of the inoculated Rhizobium associated with broad bean plants. Salem, S.H., El-Bahrawy, S.A., Radwan, H. Zentralblatt für Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Zweite naturwissenschaftliche Abt.: Allgemeine, landwirtschaftliche und technische Mikrobiologie. (1976) [Pubmed]
  6. Amphetamine- and scopolamine-induced locomotor activity following treatment with chlorphenvinphos or chlorphyriphos in rats. Lutz, P., Gralewicz, S., Kur, B., Wiaderna, D. International journal of occupational medicine and environmental health. (2005) [Pubmed]
  7. Interaction of chlorphenvinphos with cholinergic receptors in the rabbit hypothalamus. Gralewicz, S., Tomas, T., Soćko, R. Neurotoxicology and teratology. (1995) [Pubmed]
  8. Short-term effects of Quirlan(R) (chlorfenvinphos) on the behavior and acetylcholinesterase activity of Gambusia holbrooki. Sismeiro-Vivas, J., Abrantes, N., Pereira, J.L., Castro, B.B., Gonçalves, F. Environ. Toxicol. (2007) [Pubmed]
  9. Identification of chlorfenvinphos toxicity in a municipal effluent in Sydney, New South Wales, Australia. Bailey, H.C., Elphick, J.R., Krassoi, R., Mulhall, A.M., Lovell, A.J., Slee, D.J. Environ. Toxicol. Chem. (2005) [Pubmed]
  10. Susceptibility of Amblyomma variegatum ticks to acaricides in Ghana. Natala, A.J., Agyei, A.D., Awumbila, B. Exp. Appl. Acarol. (2005) [Pubmed]
  11. Different inhalation lethality between micron-sized and submicron-sized aerosols of organophosphorus insecticide, chlorfenvinphos, in rats. Takahashi, H., Yoshida, M., Murao, N., Maita, K. Toxicol. Lett. (1994) [Pubmed]
  12. Effect of chlorfenvinphos, cypermethrin and their mixture on the intestinal transport of leucine and methionine. Sedrowicz, L., Witkowska, D., Oledzka, R. Journal of applied toxicology : JAT. (1996) [Pubmed]
  13. Integrated tick and tick-borne disease control trials in crossbred dairy cattle in Malawi. Lawrence, J.A., Musisi, F.L., Mfitilodze, M.W., Tjornehoj, K., Whiteland, A.P., Kafuwa, P.T., Chamambala, K.E. Tropical animal health and production. (1996) [Pubmed]
  14. A comparison of changes in spontaneous (EEG) and evoked brain activity induced by chlorphenvinphos and physostigmine in rats and rabbits. Tomas, T., Gralewicz, S. Polish journal of occupational medicine and environmental health. (1992) [Pubmed]
  15. Impaired respiratory muscle function in chemical plant workers producing chlorfenvinphos. Konieczny, B., Kossmann, S., Makuch, M. Annals of agricultural and environmental medicine : AAEM. (1999) [Pubmed]
  16. Influence of chlorfenvinphos and ipofos on oxido-reducing processes in the rat brain mitochondria during development. Skonieczna, M., Wierciak, M., Scisłlowska, I., Bicz, W. Neuropatologia polska. (1981) [Pubmed]
  17. Neurotoxicity of chlorphenvinphos an organophosphorus pesticide: effects on blood and brain cholinesterase activity, open field behavior and response-to-change in a "T" maze in rats. Soćko, R., Gralewicz, S., Górny, R. Polish journal of occupational medicine. (1989) [Pubmed]
  18. Peripheral blood in the Japanese quail (Coturnix coturnix japonica) in acute poisoning by different insecticides. Gromysz-Kałkowska, K., Szubartowska, E., Kaczanowska, E. Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. (1985) [Pubmed]
  19. Evaluation of organophosphorus pesticide residues in citrus fruits from the Valencian community (Spain). Torres, C.M., Picó, Y., Marín, R., Mañes, J. Journal of AOAC International. (1997) [Pubmed]
  20. Central cholinergic activation by chlorfenvinphos, and organophosphate, in the rat. Osumi, Y., Fujiwara, H., Oishi, R., Takaori, S. Jpn. J. Pharmacol. (1975) [Pubmed]
  21. Activity of certain enzymes and histomorphological changes in subacute intoxication of rats with selected organophosphates. Gajewski, D., Katkiewicz, M. Acta physiologica Polonica. (1981) [Pubmed]
  22. Bioconcentration of chlorpyrifos, chlorfenvinphos, and methidathion in Mytilus galloprovincialis. Serrano, R., López, F.J., Hernández, F., Peña, J.B. Bulletin of environmental contamination and toxicology. (1997) [Pubmed]
  23. Effects of single exposure to chlorphenvinphos, an organophosphate insecticide, on electrical activity (EEG) of the rat brain. Gralewicz, S., Tomas, T., Soćko, R. Polish journal of occupational medicine. (1989) [Pubmed]
  24. cDNA cloning, baculovirus-expression and kinetic properties of the esterase, E3, involved in organophosphorus resistance in Lucilia cuprina. Newcomb, R.D., Campbell, P.M., Russell, R.J., Oakeshott, J.G. Insect Biochem. Mol. Biol. (1997) [Pubmed]
  25. Behavioral sensitization to amphetamine induced by a single i.p. dose of oxotremorine in the rat. Gralewicz, S. Acta neurobiologiae experimentalis. (2002) [Pubmed]
  26. The effect of arsenical dips on Parafilaria bovicola in artificially infected cattle in South Africa. Nevill, E.M. Onderstepoort J. Vet. Res. (1985) [Pubmed]
 
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