Disease relevance of Dermaton

• A good inverse correlation between the acute oral toxicity of chlorfenvinphos and its rate of oxidative detoxification in the liver exists for rats, mice, rabbits and dogs [1].
• Effect of dimethoate and chlorfenvinphos on plasma membrane integrity of Synechocystis sp. PCC 6803 [2].
• Effect of chlorfenvinphos on rat liver subjected to ischemia and reperfusion [3].
• Dietary protein deficiency and the influence of chlorfenvinphos on the biological parameters in rats [4].
• Birlane (insecticide) was found to be the most inhibitory insecticide on the inoculated rhizobium [5].

Psychiatry related information on Dermaton

• Amphetamine- and scopolamine-induced locomotor activity following treatment with chlorphenvinphos or chlorphyriphos in rats [6].

High impact information on Dermaton

• Interaction of chlorphenvinphos with cholinergic receptors in the rabbit hypothalamus [7].
• A strong inhibition of AChE was observed in fish exposed to chlorfenvinphos (IC50 = 3.55 mug L(-1)) [8].
• Source-control measures were effective at eliminating chlorfenvinphos and associated toxicity from the discharge [9].
• Gamma benzene hexachloride produced only 66% inhibition of oviposition while chlorfenvinphos and dioxathion combined and chlorfenvinphos alone produced 100% inhibition of oviposition at their recommended dose rates [10].
• The reduction in amount of uranine trapped inside the cells was greater in cultures treated with chlorfenvinphos, whereas quenching of ACMA fluorescence was found to be greater with dimethoate treatment [2].

Biological context of Dermaton

• This study was designed to evaluate that a difference in the route of absorption or the mode of lethality is responsible for the higher inhalation lethality of micron-sized organophosphorus insecticide, chlorfenvinphos (CVP), aerosols than the submicron-sized aerosols [11].
• The findings allow the conclusion that oral administration of chlorfenvinphos, cypermethrin and their mixture in a dose of 5% LD50 impairs the intestinal transport of Leu and Met and alters their distribution in the rodent body [12].
• They were treated at infrequent intervals with chlorfenvinphos to limit infestation with adult ticks, without providing complete tick control [13].
• The effects of single i.p. injections of two cholinesterase inhibitors, chlorphenvinphos (CVP) and physostigmine, on hippocampal and cortical EEG and flash evoked potentials in occipital cortex were compared in rabbits and rats [14].
• Mean air chlorfenvinphos concentrations in the work environment estimated with gas-liquid chromatography were from 0.0008-0.0018 mg/m3 (maximum allowable concentration according to Polish standards is 0. 01 mg/m3) [15].

Anatomical context of Dermaton

• It seems that respiratory muscles impairment in humans exposed to chlorfenvinphos results from changes in the metabolism and structure of muscles, and partly from lung hyperinflation [15].
• Influence of chlorfenvinphos and ipofos on oxido-reducing processes in the rat brain mitochondria during development [16].
• Cholinesterase (ChE) activity in blood (plasma and erythrocytes) and in different parts of the brain, open field behavior and response-to-change in a "T" maze were investigated in separate groups of rats after a single intraperitoneal exposure to an organophosphorus pesticide - chlorphenvinphos [17].
• A marked increase in the number of basophils was found after ingesting chlorphenvinphos, and a distinct increase in monocytes after ingesting both pesticides [18].
• Chlorphenvinphos significantly reduces, but foschlor increases, thrombocyte content [18].

Associations of Dermaton with other chemical compounds

• The organophosphorus pesticides carbophenothion, chlorpyriphos, chlorfenvinphos, diazinon, ethion, fenitrothion, malathion, methidation, methylparathion, phosmet, quinalphos, and tetradifon were simultaneously extracted by matrix solid-phase dispersion and determined by gas chromatography-mass spectrometry using selected ion monitoring mode [19].
• Atropine depressed the EEG arousal pattern induced by chlorfenvinphos, without affecting ChE activity in the brain [20].
• The reported investigations were carried out on female Wistar rats which were given at 72-hour interval during 117 days (40 doses) dichlorphos subcutaneously, intragastrically and percutaneously, and chlorphenvinphos, bromphenvinphos, methylbromphenvinphos and phospholine subcutaneously in doses amounting to 5% of LD50 [21].
• Bioconcentration of chlorpyrifos, chlorfenvinphos, and methidathion in Mytilus galloprovincialis [22].
• The effect of a single exposure to an agricultural insecticide, chlorphenvinphos (CVP), an organophosphorus anticholinesterase, on neocortical seizure activity induced or promoted by cardiazol, and on hippocampal and neocortical EEG was studied in rats [23].

Gene context of Dermaton

• The enzyme is potently inhibited by OPs (ki [paraoxon] = 6.3 +/- 1.4 x 10(7)/M/min, ki [chlorfenvinphos] = 5.9 +/- 0.6 x 10(7)/M/min) and exhibits a high turnover of methylthiobutyrate (1009/s), consistent with its proposed homology to the ali-esterase that is thought to mutate to confer OP resistance in Musca domestica [24].
• Earlier experiments have revealed that rats treated with a single dose of chlorphenvinphos (CVP), an irreversible acetylcholinesterase inhibitor, are hyposensitive to amphetamine (AMPH) given three weeks after CVP [25].
• OBJECTIVES: Effects of acute exposure to organophosphorous pesticides (OPs), chlorphenvinphos (CVP) or chlorphyriphos (CPF) on amphetamine (AMPH)- or scopolamine (SCOP)-induced open-field locomotion were compared in rats [6].

Analytical, diagnostic and therapeutic context of Dermaton

• These results indicate that the appearance of EEG arousal pattern after chlorfenvinphos may be derived from central cholinergic activation [20].
• In groups 8 and 9 rat livers were subjected to 90-min ischemia, 12- or 24-hour reperfusion and then rats were injected with chlorfenvinphos (2 mg/kg b.w.). Liver sections were evaluated morphologically, histochemically (SDH, LDH, G6Pase, glycogen, Mg2+ ATPase and AcP) [3].
• A control group of the same size was dipped in an organophosphate dip containing a mixture of chlorfenvinphos and dioxathion [26].
• Intraperitoneal injection of chlorfenvinphos during ischemia and reperfusion dramatically intensifies damage to the liver, although chlorfenvinphos alone produces only mild nonspecific effects on the morphological and enzymatic structure of the liver [3].

References