Disease relevance of Seroma

• Two patients had minor complications: a seroma at the repair site, which resolved spontaneously, and a superficial wound infection at a trochar site, which responded to an oral cephalosporin [1].
• The complications reported are similar to other implantable infusion devices and include dehiscence of the suture line, pressure ulcer development, formation of seroma, inversion of the pump, baclofen overdose, and catheter failures [2].

High impact information on Seroma

• Only 1 minor complication occurred (wound seroma) and 1 donor had creatinine persistently elevated to 1.9 mg/dl (normal 0.6 to 1.2) [3].
• Noninfectious seromas are characterized generally by the accumulation of clear serous fluid with a protein and glucose content of serum and the lack of acute inflammatory cells when the sediment is examined [4].
• The frequency of postoperative seroma formation was also decreased by tranexamic acid administration (27 versus 37 per cent, P = 0.2) [5].
• BACKGROUND: This study was designed to determine the effectiveness of Hemaseel APR fibrin sealant versus conventional drain placement in the prevention of seromas after breast procedures [6].
• In patients with seroma, the levels of IL-4 and interferon-gamma were persistently low and were both statistically significant [7].

Chemical compound and disease context of Seroma

• CONCLUSIONS: Our data suggest that the use of heparin leads to an increased risk of perigraft seroma, complicating systemic-pulmonary polytetrafluoroethylene grafts [8].
• Carbon dioxide laser incisions are reported to be less painful, less bloody, and less prone to seroma formation and to heal better than scalpel or electrosurgical incisions [9].
• CONCLUSIONS: Topical tetracycline is not effective at preventing post-mastectomy wound seromas [10].
• Polidocanol for refractory seroma [11].
• The current study describes what we believe is the first report of bilateral massive seromas associated with open-cell Ivalon sponges [12].

Biological context of Seroma

• To conclude, IL-6 and tumor necrosis factor-alpha are important in normal postoperative wound healing and IL-4 and interferon-gamma may be associated with postoperative necrosis and seroma [7].

Anatomical context of Seroma

• The goals of the current study were to determine the biological activity of postsurgical wound exudates (seroma fluids) on normal neutrophil and lymphocyte function and to quantitate the levels of complement and plasma fibronectin in these wound exudates [13].

Gene context of Seroma

• Modulation of CD2 expression with seroma alone appeared to result in the generation of this highly cytotoxic population [14].
• Interleukin-2 activation of cytotoxic cells in postmastectomy seroma [14].
• Compared with normal-weight patients, obese patients had a significantly higher rate of overall flap complications (39.1 versus 20.4 percent; p = 0.001), total flap loss (3.2 versus 0 percent; p = 0.001), flap seroma (10.9 versus 3.2 percent; p = 0.004), and mastectomy flap necrosis (21.9 versus 6.6 percent; p = 0.001) [15].
• BACKGROUND: Large symptomatic mediastinal seroma following modified-BT shunts, traditionally required revisional thoracotomy [16].

Analytical, diagnostic and therapeutic context of Seroma

• METHODS: A prospective, randomized, double-blinded trial was performed to examine the effect of intraoperatively administered topical tetracycline on the occurrence of postoperative mastectomy seromas [10].
• Sclerotherapy with 50% dextrose is not beneficial in the management of recurrent disease or postoperative seromas [17].
• Seroma formation 2 weeks postoperatively was greater in the tetracycline group than the control group (53% vs. 22%, P = 0.01) [10].

References