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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Seroma

  • Two patients had minor complications: a seroma at the repair site, which resolved spontaneously, and a superficial wound infection at a trochar site, which responded to an oral cephalosporin [1].
  • The complications reported are similar to other implantable infusion devices and include dehiscence of the suture line, pressure ulcer development, formation of seroma, inversion of the pump, baclofen overdose, and catheter failures [2].

High impact information on Seroma

  • Only 1 minor complication occurred (wound seroma) and 1 donor had creatinine persistently elevated to 1.9 mg/dl (normal 0.6 to 1.2) [3].
  • Noninfectious seromas are characterized generally by the accumulation of clear serous fluid with a protein and glucose content of serum and the lack of acute inflammatory cells when the sediment is examined [4].
  • The frequency of postoperative seroma formation was also decreased by tranexamic acid administration (27 versus 37 per cent, P = 0.2) [5].
  • BACKGROUND: This study was designed to determine the effectiveness of Hemaseel APR fibrin sealant versus conventional drain placement in the prevention of seromas after breast procedures [6].
  • In patients with seroma, the levels of IL-4 and interferon-gamma were persistently low and were both statistically significant [7].

Chemical compound and disease context of Seroma

  • CONCLUSIONS: Our data suggest that the use of heparin leads to an increased risk of perigraft seroma, complicating systemic-pulmonary polytetrafluoroethylene grafts [8].
  • Carbon dioxide laser incisions are reported to be less painful, less bloody, and less prone to seroma formation and to heal better than scalpel or electrosurgical incisions [9].
  • CONCLUSIONS: Topical tetracycline is not effective at preventing post-mastectomy wound seromas [10].
  • Polidocanol for refractory seroma [11].
  • The current study describes what we believe is the first report of bilateral massive seromas associated with open-cell Ivalon sponges [12].

Biological context of Seroma

  • To conclude, IL-6 and tumor necrosis factor-alpha are important in normal postoperative wound healing and IL-4 and interferon-gamma may be associated with postoperative necrosis and seroma [7].

Anatomical context of Seroma


Gene context of Seroma

  • Modulation of CD2 expression with seroma alone appeared to result in the generation of this highly cytotoxic population [14].
  • Interleukin-2 activation of cytotoxic cells in postmastectomy seroma [14].
  • Compared with normal-weight patients, obese patients had a significantly higher rate of overall flap complications (39.1 versus 20.4 percent; p = 0.001), total flap loss (3.2 versus 0 percent; p = 0.001), flap seroma (10.9 versus 3.2 percent; p = 0.004), and mastectomy flap necrosis (21.9 versus 6.6 percent; p = 0.001) [15].
  • BACKGROUND: Large symptomatic mediastinal seroma following modified-BT shunts, traditionally required revisional thoracotomy [16].

Analytical, diagnostic and therapeutic context of Seroma


  1. Laparoscopic ventral hernia repair: a community hospital experience. Saiz, A.A., Willis, I.H., Paul, D.K., Sivina, M. The American surgeon. (1996) [Pubmed]
  2. Intrathecal drug therapy using the Codman Model 3000 Constant Flow Implantable Infusion Pumps: experience with 17 cases. Ethans, K.D., Schryvers, O.I., Nance, P.W., Casey, A.R. Spinal Cord (2005) [Pubmed]
  3. Laparoscopic donor nephrectomy at a low volume living donor transplant center: successful outcomes can be expected. Duchene, D.A., Johnson, D.B., Li, S., Roden, J.S., Sagalowsky, A.I., Cadeddu, J.A. J. Urol. (2003) [Pubmed]
  4. The management of massive ultrafiltration distending the aneurysm sac after abdominal aortic aneurysm repair with a polytetrafluoroethylene aortobiiliac graft. Williams, G.M. J. Vasc. Surg. (1998) [Pubmed]
  5. Perioperative and postoperative tranexamic acid reduces the local wound complication rate after surgery for breast cancer. Oertli, D., Laffer, U., Haberthuer, F., Kreuter, U., Harder, F. The British journal of surgery. (1994) [Pubmed]
  6. Influence of fibrin glue on seroma formation after breast surgery. Johnson, L., Cusick, T.E., Helmer, S.D., Osland, J.S. Am. J. Surg. (2005) [Pubmed]
  7. The study of cytokine dynamics at the operation site after mastectomy. Chow, L.W., Loo, W.T., Yuen, K.Y., Cheng, C. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. (2003) [Pubmed]
  8. Heparin as a risk factor for perigraft seroma complicating the modified Blalock-Taussig shunt. Berger, R.M., Bol-Raap, G., Hop, W.J., Bogers, A.J., Hess, J. J. Thorac. Cardiovasc. Surg. (1998) [Pubmed]
  9. A prospective study of incisional time, blood loss, pain, and healing with carbon dioxide laser, scalpel, and electrosurgery. Pearlman, N.W., Stiegmann, G.V., Vance, V., Norton, L.W., Bell, R.C., Staerkel, R., Van Way, C.W., Bartle, E.J. Archives of surgery (Chicago, Ill. : 1960) (1991) [Pubmed]
  10. Intraoperative topical tetracycline sclerotherapy following mastectomy: a prospective, randomized trial. Rice, D.C., Morris, S.M., Sarr, M.G., Farnell, M.B., van Heerden, J.A., Grant, C.S., Rowland, C.M., Ilstrup, D.M., Donohue, J.H. Journal of surgical oncology. (2000) [Pubmed]
  11. Polidocanol for refractory seroma. Laverson, S. Plast. Reconstr. Surg. (1999) [Pubmed]
  12. The clinical, histologic, and ultrastructural presentation of polyvinyl sponge (Ivalon) breast prostheses removed for massive fluid accumulation. Smith, A.R., Garrison, J.L., Greene, W.B., Raso, D.S. Plast. Reconstr. Surg. (1999) [Pubmed]
  13. Effects of wound exudates on in vitro immune parameters. Bridges, M., Morris, D., Hall, J.R., Deitch, E.A. J. Surg. Res. (1987) [Pubmed]
  14. Interleukin-2 activation of cytotoxic cells in postmastectomy seroma. Gercel-Taylor, C., Hoffman, J.P., Taylor, D.D., Owens, K.J., Eisenberg, B.L. J. Surg. Res. (1996) [Pubmed]
  15. Effect of obesity on flap and donor-site complications in free transverse rectus abdominis myocutaneous flap breast reconstruction. Chang, D.W., Wang, B., Robb, G.L., Reece, G.P., Miller, M.J., Evans, G.R., Langstein, H.N., Kroll, S.S. Plast. Reconstr. Surg. (2000) [Pubmed]
  16. Early mediastinal seroma secondary to modified Blalock-Taussig shunts--successful management by percutaneous drainage. Connolly, B.L., Temple, M.J., Chait, P.G., Restrepo, R., Adatia, I. Pediatric radiology. (2003) [Pubmed]
  17. Complications of lymphangiomas in children. Hancock, B.J., St-Vil, D., Luks, F.I., Di Lorenzo, M., Blanchard, H. J. Pediatr. Surg. (1992) [Pubmed]
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