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Disease relevance of Thoracotomy


Psychiatry related information on Thoracotomy

  • Phase 2: Pain after circumcostal closure (7 dogs) or transcostal closure (6 dogs) of a 4th intercostal space thoracotomy was evaluated by use of pain threshold scores, fentanyl administration rates, heart and respiratory rates, and numerical ratings for behavior [6].

High impact information on Thoracotomy

  • Genomic DNA was extracted from 39 tumor specimens obtained by thoracotomy and was examined for activating point mutations in codons 12, 13, and 61 of the H-ras, K-ras, and N-ras genes [7].
  • Cardiac afferent nerve function was assessed in control and treatment regions by the epicardial application of bradykinin, a potent algesic, at initial thoracotomy before laser treatment, and at repeat thoracotomy 2 weeks later [8].
  • Male, mongrel dogs (13.0-20.0 kg) were anesthetized (30 mg/kg i.v. sodium pentobarbital), and a left thoracotomy was performed [9].
  • It identifies a large subset of patients with specific forms of restrictive cardiomyopathy in whom thoracotomy should be avoided [10].
  • Quantitative comparisons of infarcts 24 hours after ligation of the left anterior descending coronary artery (LAD) via thoracotomy were made in 13 control and 13 dogs treated with i.v. 25% mannitol, 2 ml/min for 4 hours following occlusion [11].

Chemical compound and disease context of Thoracotomy


Biological context of Thoracotomy


Anatomical context of Thoracotomy

  • PSD was produced by placing a split nylon ring around the thoracic aorta of the rabbits at a level of T6-7 during a sterile thoracotomy done under pentobarbital anesthesia [22].
  • Using a sterile technique, the pericardium was opened by way of a right thoracotomy, Teflon-coated, stainless steel wire electrodes were fixed to three selected sites on the atria and exteriorized, the atrial surfaces were generously dusted with talcum powder and a single layer of gauze was placed on the free left and right atrial walls [23].
  • We have examined the in vivo airway responsiveness to leukotriene (LT) D4 in 11 patients without asthma who were to undergo thoracotomy and compared this responsiveness with in vitro sensitivity and in vitro contractility of bronchial smooth muscle to LTD4 [24].
  • After exposing the LV myocardium via a limited lateral thoracotomy, each of 17 patients in this series received 4 separate injections of VEGF DNA into different myocardial sites [25].
  • At the time of the thoracotomy, the ceftriaxone concentrations were 13.5 +/- 7.8 micrograms/g in thoracic wall fat and 27 +/- 9 micrograms/g in lung tissue [26].

Associations of Thoracotomy with chemical compounds

  • Although normal initially (mean 19 +/- 5.0%), lactate extraction after thoracotomy, before aortic cross-clamping, became abnormal in 12 patients with more pronounced abnormality in those with perioperative MI (-19 +/- 9.0%) [27].
  • Interoperative amikacin irrigation, even with immediate aspiration, results in significant absorption in both thoracotomy and laporatomy patients [28].
  • After demonstrating the perforation with a Gastrografin swallow, a left posterolateral thoracotomy is made [29].
  • Forty-six New Zealand white (NZW) rabbits underwent treatment with CO2 laser (n=18), Nd:YAG laser (n=18), or sham thoracotomy control (n=10) to the visceral pleural surface using 1 min of exposure (5 watts, defocused to 70 W/cm2 power density for both lasers) [30].
  • In the present study, the tissue content of acetylcholine and release of [3H]acetylcholine were measured in freshly dissected human bronchi obtained at thoracotomy [31].

Gene context of Thoracotomy

  • Minimal to no detectable MIP-1 alpha was expressed in alveolar M phi from healthy subjects or interstitial cells in lung biopsy specimens obtained from patients undergoing thoracotomy for malignancy [32].
  • METHODS: The hearts in TNF-alpha KO and wild-type (WT) mice were exposed by left lateral thoracotomy, and the left coronary artery was occluded for 30 min then reperfused for 120 min [33].
  • As such, the expression and localization of nitric oxide synthase (NOS) isoforms was assessed in human airway tissue obtained following thoracotomy, and in cultured human airway epithelial (BEAS-2B) cells [34].
  • To examine a potential contribution of protooncogene abnormalities other than point-mutational activation of the K-ras protooncogene in the classification of non-small cell lung cancer, amplification of cellular protooncogenes was studied in 47 lung tumour specimens obtained at thoracotomy and in four lung tumour cell lines [35].
  • Spinal prostaglandin formation and pain perception following thoracotomy: a role for cyclooxygenase-2 [36].

Analytical, diagnostic and therapeutic context of Thoracotomy


  1. Expression of CYP1A1 gene in patients with lung cancer: evidence for cigarette smoke-induced gene expression in normal lung tissue and for altered gene regulation in primary pulmonary carcinomas. McLemore, T.L., Adelberg, S., Liu, M.C., McMahon, N.A., Yu, S.J., Hubbard, W.C., Czerwinski, M., Wood, T.G., Storeng, R., Lubet, R.A. J. Natl. Cancer Inst. (1990) [Pubmed]
  2. Microwave coagulation therapy for hepatocellular carcinoma. Sato, M., Watanabe, Y., Ueda, S., Iseki, S., Abe, Y., Sato, N., Kimura, S., Okubo, K., Onji, M. Gastroenterology (1996) [Pubmed]
  3. The results of esophagogastrectomy without thoracotomy for adenocarcinoma of the esophagogastric junction. Finley, R.J., Inculet, R.I. Ann. Surg. (1989) [Pubmed]
  4. Deep vein thrombosis after thoracotomy. Jackaman, F.R., Perry, B.J., Siddons, H. Thorax (1978) [Pubmed]
  5. Effect of pre-emptive ketamine on sensory changes and postoperative pain after thoracotomy: comparison of epidural and intramuscular routes. Ozyalcin, N.S., Yucel, A., Camlica, H., Dereli, N., Andersen, O.K., Arendt-Nielsen, L. British journal of anaesthesia. (2004) [Pubmed]
  6. Intercostal thoracotomy closure: transcostal sutures as a less painful alternative to circumcostal suture placement. Rooney, M.B., Mehl, M., Monnet, E. Veterinary surgery : VS : the official journal of the American College of Veterinary Surgeons. (2004) [Pubmed]
  7. Mutational activation of the K-ras oncogene. A possible pathogenetic factor in adenocarcinoma of the lung. Rodenhuis, S., van de Wetering, M.L., Mooi, W.J., Evers, S.G., van Zandwijk, N., Bos, J.L. N. Engl. J. Med. (1987) [Pubmed]
  8. Nontransmural laser treatment incompletely denervates canine myocardium. Kwong, K.F., Schuessler, R.B., Kanellopoulos, G.K., Saffitz, J.E., Sundt, T.M. Circulation (1998) [Pubmed]
  9. Combined adenosine and lidocaine administration limits myocardial reperfusion injury. Homeister, J.W., Hoff, P.T., Fletcher, D.D., Lucchesi, B.R. Circulation (1990) [Pubmed]
  10. Restrictive cardiomyopathy versus constrictive pericarditis: role of endomyocardial biopsy in avoiding unnecessary thoracotomy. Schoenfeld, M.H., Supple, E.W., Dec, G.W., Fallon, J.T., Palacios, I.F. Circulation (1987) [Pubmed]
  11. The effect of mannitol following permanent coronary occlusion. Hirzel, H.O., Kirk, E.S. Circulation (1977) [Pubmed]
  12. Extrapleural regional versus systemic analgesia for relieving postthoracotomy pain: a clinical study of bupivacaine compared with metamizol. Bilgin, M., Akcali, Y., Oguzkaya, F. J. Thorac. Cardiovasc. Surg. (2003) [Pubmed]
  13. Continuous intercostal blockade with lidocaine after thoracic surgery. Clinical and pharmacokinetic study. Safran, D., Kuhlman, G., Orhant, E.E., Castelain, M.H., Journois, D. Anesth. Analg. (1990) [Pubmed]
  14. The role of video-assisted thoracoscopic surgery in the management of pulmonary tuberculosis. Yim, A.P. Chest (1996) [Pubmed]
  15. Acute pain management for patients undergoing thoracotomy. Soto, R.G., Fu, E.S. Ann. Thorac. Surg. (2003) [Pubmed]
  16. Effects of in vitro mast cell degranulation on human lung beta-receptor binding parameters. Casale, T.B. Ann. Allergy Asthma Immunol. (1996) [Pubmed]
  17. Incidence and possible clinical significance of K-ras oncogene activation in adenocarcinoma of the human lung. Rodenhuis, S., Slebos, R.J., Boot, A.J., Evers, S.G., Mooi, W.J., Wagenaar, S.S., van Bodegom, P.C., Bos, J.L. Cancer Res. (1988) [Pubmed]
  18. Relationship between the pharmacokinetics and the analgesic and respiratory pharmacodynamics of epidural sufentanil. Koren, G., Sandler, A.N., Klein, J., Whiting, W.C., Lau, L.C., Slavchenko, P., Daley, D. Clin. Pharmacol. Ther. (1989) [Pubmed]
  19. Efficacy of continuous extrapleural intercostal nerve block on post-thoracotomy pain and pulmonary mechanics. Sabanathan, S., Mearns, A.J., Bickford Smith, P.J., Eng, J., Berrisford, R.G., Bibby, S.R., Majid, M.R. The British journal of surgery. (1990) [Pubmed]
  20. The CSF and plasma pharmacokinetics of sufentanil after intrathecal administration. Hansdottir, V., Hedner, T., Woestenborghs, R., Nordberg, G. Anesthesiology (1991) [Pubmed]
  21. Distribution of extravascular lung water after acute smoke inhalation. Clark, W.R., Nieman, G., Hakim, T.S. J. Appl. Physiol. (1990) [Pubmed]
  22. Morphometric analyses of rabbit thoracic aorta after poststenotic dilatation. Kukongviriyapan, U., Gow, B.S. Circ. Res. (1989) [Pubmed]
  23. A new animal model of atrial flutter. Pagé, P.L., Plumb, V.J., Okumura, K., Waldo, A.L. J. Am. Coll. Cardiol. (1986) [Pubmed]
  24. In vivo and in vitro human airway responsiveness to leukotriene D4 in patients without asthma. Roberts, J.A., Rodger, I.W., Thomson, N.C. J. Allergy Clin. Immunol. (1987) [Pubmed]
  25. Intraoperative multiplane transesophageal echocardiography for guiding direct myocardial gene transfer of vascular endothelial growth factor in patients with refractory angina pectoris. Esakof, D.D., Maysky, M., Losordo, D.W., Vale, P.R., Lathi, K., Pastore, J.O., Symes, J.F., Isner, J.M. Hum. Gene Ther. (1999) [Pubmed]
  26. Pharmacokinetics and tissue penetration of a single dose of ceftriaxone (1,000 milligrams intravenously) for antibiotic prophylaxis in thoracic surgery. Martin, C., Ragni, J., Lokiec, F., Guillen, J.C., Auge, A., Pecking, M., Gouin, F. Antimicrob. Agents Chemother. (1992) [Pubmed]
  27. Coronary sinus blood flow and sampling for detection of unrecognized myocardial ischemia and injury. Gray, R.J., Harris, W.S., Shah, P.K., Miyamoto, A.T., Matloff, J.M., Swan, H.J. Circulation (1977) [Pubmed]
  28. Amikacin concentrations in serum following intraoperative irrigation of the pleura and peritoneum. Van Way, C.W., Hasse, G. Ann. Surg. (1985) [Pubmed]
  29. Esophageal perforations after forceful dilatation in achalasia. Slater, G., Sicular, A.A. Ann. Surg. (1982) [Pubmed]
  30. CO2 and Nd:YAG laser-induced pulmonary parenchymal lung injury in a rabbit model. Brenner, M., Shankel, T., Wang, N.S., Waite, T.A., Wong, H., Hamilton, A., Tadir, Y., Milner, T., Boyajian, J., Chung, E., Tromberg, B., Wilson, A.F., Berns, M.W. Am. J. Respir. Crit. Care Med. (1996) [Pubmed]
  31. Release of [3H]acetylcholine in human isolated bronchi. Effect of indomethacin on muscarinic autoinhibition. Wessler, I., Bender, H., Härle, P., Höhle, K.D., Kirdorf, G., Klapproth, H., Reinheimer, T., Rícný, J., Schniepp-Mendelssohn, K.E., Racké, K. Am. J. Respir. Crit. Care Med. (1995) [Pubmed]
  32. Macrophage inflammatory protein-1 alpha expression in interstitial lung disease. Standiford, T.J., Rolfe, M.W., Kunkel, S.L., Lynch, J.P., Burdick, M.D., Gilbert, A.R., Orringer, M.B., Whyte, R.I., Strieter, R.M. J. Immunol. (1993) [Pubmed]
  33. Improved myocardial ischemia/reperfusion injury in mice lacking tumor necrosis factor-alpha. Maekawa, N., Wada, H., Kanda, T., Niwa, T., Yamada, Y., Saito, K., Fujiwara, H., Sekikawa, K., Seishima, M. J. Am. Coll. Cardiol. (2002) [Pubmed]
  34. Expression and activity of nitric oxide synthases in human airway epithelium. Watkins, D.N., Peroni, D.J., Basclain, K.A., Garlepp, M.J., Thompson, P.J. Am. J. Respir. Cell Mol. Biol. (1997) [Pubmed]
  35. Cellular protoonocogenes are infrequently amplified in untreated non-small cell lung cancer. Slebos, R.J., Evers, S.G., Wagenaar, S.S., Rodenhuis, S. Br. J. Cancer (1989) [Pubmed]
  36. Spinal prostaglandin formation and pain perception following thoracotomy: a role for cyclooxygenase-2. McCrory, C., Fitzgerald, D. Chest (2004) [Pubmed]
  37. Injury of the human diaphragm associated with exertion and chronic obstructive pulmonary disease. Orozco-Levi, M., Lloreta, J., Minguella, J., Serrano, S., Broquetas, J.M., Gea, J. Am. J. Respir. Crit. Care Med. (2001) [Pubmed]
  38. Serum prolactin after chest wall surgery: elevated levels after mastectomy. Herman, V., Kalk, W.J., de Moor, N.G., Levin, J. J. Clin. Endocrinol. Metab. (1981) [Pubmed]
  39. Myocardial infarct size is smaller in dogs with pacing-induced heart failure. Hoskins, D.E., Ignasiak, D.P., Saganek, L.J., Gallagher, K.P., Peterson, J.T. Cardiovasc. Res. (1996) [Pubmed]
  40. A randomized comparison of intravenous versus lumbar and thoracic epidural fentanyl for analgesia after thoracotomy. Guinard, J.P., Mavrocordatos, P., Chiolero, R., Carpenter, R.L. Anesthesiology (1992) [Pubmed]
  41. Centriacinar alterations in lungs of cats chronically exposed to diesel exhaust. Plopper, C.G., Hyde, D.M., Weir, A.J. Lab. Invest. (1983) [Pubmed]
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