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MeSH Review

Complement Hemolytic Activity Assay

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Disease relevance of Complement Hemolytic Activity Assay


High impact information on Complement Hemolytic Activity Assay

  • Serum from this patient demonstrated a fall in C3, C4, and total hemolytic complement levels during the syndrome, in association with circulating IgM immune complexes [6].
  • Moreover, simple incubation of human plasma with dialyzer cellophane causes conversion of C3 and factor B, accompanied by depletion of total hemolytic complement and C3 but sparing of hemolytic C1 [7].
  • The levels were compared with levels of total hemolytic complement and immunochemical determinations of Cl1 and C3 [8].
  • When adjusted for total protein, synovial levels of total hemolytic complement, C3, C4, and alpha 2-M did not differ significantly in the two groups [2].
  • Interactions of heparin and protamine in fresh human serum, in amounts far below those required for complement depletion by either agent alone, were found to induce virtually complete depletion of total hemolytic complement activity [9].

Chemical compound and disease context of Complement Hemolytic Activity Assay


Biological context of Complement Hemolytic Activity Assay


Anatomical context of Complement Hemolytic Activity Assay


Associations of Complement Hemolytic Activity Assay with chemical compounds

  • Examination of the synovial and pericardial fluid showed noteworthy decreases in total hemolytic complement (CH50) and C3 levels, while these were normal in the serum [19].
  • RF mixed with aggregated, reduced, and alkylated human IgG (Agg-R/A-IgG) in the fluid phase failed to significantly reduce the level of total hemolytic complement, CH50, or of individual complement components, C1, C2, C3, and C5 [20].
  • Serum complement profiles performed on these patients found low total hemolytic complement assays, normal concentrations of C1q, and low or undetectable concentrations of C3 through C6, C8, C9, and factors B and I [21].
  • Serum levels of total hemolytic complement, C3, and factor B decreased following heat challenge, whereas levels of C4 and C5 did not [22].
  • Incubation of cells of H. influenzae type b in C2-deficient serum or AGS-Mg-EGTA did not cause complement consumption (total hemolytic complement and C3) [23].

Gene context of Complement Hemolytic Activity Assay


Analytical, diagnostic and therapeutic context of Complement Hemolytic Activity Assay


  1. Cold dependent activation of complement in systemic lupus erythematosus. A unique cause for a discrepancy between clinical and laboratory parameters. Atkinson, J.P., Gorman, J.C., Curd, J., Hyla, J.F., Deegan, M.J., Keren, D.F., Abdou, N.I., Walker, S.E. Arthritis Rheum. (1981) [Pubmed]
  2. Synovial fluid in seronegative juvenile rheumatoid arthritis: studies of immunoglobulins, complements, and alpha 2-macroglobulin. Martin, C.L., Pachman, L.M. Arthritis Rheum. (1980) [Pubmed]
  3. Complement consumption in acute disseminated intravascular coagulation without antecedent immunopathology. Branson, H.E., Wyatt, L.L., Schmer, G. Am. J. Clin. Pathol. (1976) [Pubmed]
  4. Endotoxin-challenged monkeys and rats. Erve, P.R., Schuler, J.J., Schumer, W. Archives of surgery (Chicago, Ill. : 1960) (1978) [Pubmed]
  5. Examination of baseline levels of carboxypeptidase N and complement components as potential predictors of angioedema associated with the use of an angiotensin-converting enzyme inhibitor. Sigler, C., Annis, K., Cooper, K., Haber, H., Van deCarr, S. Archives of dermatology. (1997) [Pubmed]
  6. Acute non-A, non-B hepatitis with serum sickness-like syndrome and aplastic anemia. Perrillo, R.P., Pohl, D.A., Roodman, S.T., Tsai, C.C. JAMA (1981) [Pubmed]
  7. Hemodialysis leukopenia. Pulmonary vascular leukostasis resulting from complement activation by dialyzer cellophane membranes. Craddock, P.R., Fehr, J., Dalmasso, A.P., Brighan, K.L., Jacob, H.S. J. Clin. Invest. (1977) [Pubmed]
  8. Circulating immune complexes detected by 125I-Clq deviation test in sera of cancer patients. Teshima, H., Wanebo, H., Pinsky, C., Day, N.K. J. Clin. Invest. (1977) [Pubmed]
  9. Complement activation by interaction of polyanions and polycations. I. Heparin-protamine induced consumption of complement. Rent, R., Ertel, N., Eisenstein, R., Gewurz, H. J. Immunol. (1975) [Pubmed]
  10. Good response of membranous lupus nephritis to tacrolimus. Maruyama, M., Yamasaki, Y., Sada, K., Sarai, A., Ujike, K., Maeshima, Y., Nakamura, Y., Sugiyama, H., Makino, H. Clin. Nephrol. (2006) [Pubmed]
  11. Activation of plasma systems and blood cells by endotoxin in rabbits. Jansen, N.J., van Oeveren, W., Hoiting, B.H., Wildevuur, C.R. Inflammation (1991) [Pubmed]
  12. Significance of sequential changes in serum complement levels during acute anaphylactoid reactions. Fisher, M.M., Teisnner, B., Charlesworth, J. Crit. Care Med. (1984) [Pubmed]
  13. Lack of association between the HLA-A10 (A25), B18 and C2o haplotype and anaphylactoid purpura (AP). Krüger, J., Opferkuch, W., Evers, K.G., Bosecker, L., Haase, W. Tissue Antigens (1980) [Pubmed]
  14. Adult-onset Still's disease. Twenty-year followup and further studies of patients with active disease. Elkon, K.B., Hughes, G.R., Bywaters, E.G., Ryan, P.F., Inman, R.D., Bowley, N.B., James, M.P., Eady, R.A. Arthritis Rheum. (1982) [Pubmed]
  15. Effects of centrifugation leukapheresis with hydroxyethyl starch on the complement system of granulocyte donors. McLeod, B.C., Sassetti, R.J. Transfusion (1981) [Pubmed]
  16. Interference with total hemolytic complement assay in rheumatoid arthritis: correlation with disease activity. Lakhanpal, S., Conn, D.L. J. Rheumatol. (1986) [Pubmed]
  17. Activation of complement by radiographic contrast media: generation of chemotactic and anaphylatoxin activities. Till, G., Rother, U., Gemsa, D. Int. Arch. Allergy Appl. Immunol. (1978) [Pubmed]
  18. Immunochemical quantitation of serum complement components in SFD and AFD infants. Ueda, H., Nakanishi, A., Ichijo, M. Tohoku J. Exp. Med. (1980) [Pubmed]
  19. Rheumatoid pericarditis. Rapid deterioration with evidence of local vasculitis. Butman, S., Espinoza, L.R., Del Carpio, J., Osterland, C.K. JAMA (1977) [Pubmed]
  20. Complement fixation by rheumatoid factor. Tanimoto, K., Cooper, N.R., Johnson, J.S., Vaughan, J.H. J. Clin. Invest. (1975) [Pubmed]
  21. Meningococcemia and acquired complement deficiency. Association in patients with hepatic failure. Ellison, R.T., Mason, S.R., Kohler, P.F., Curd, J.G., Reller, L.B. Arch. Intern. Med. (1986) [Pubmed]
  22. Localized heat urticaria. Daman, L., Lieberman, P., Ganier, M., Hashimoto, K. J. Allergy Clin. Immunol. (1978) [Pubmed]
  23. Antibody-dependent alternative pathway killing of Haemophilus influenzae type b. Steele, N.P., Munson, R.S., Granoff, D.M., Cummins, J.E., Levine, R.P. Infect. Immun. (1984) [Pubmed]
  24. Complement and contrast material reactors. Lasser, E.C., Lang, J.H., Lyon, S.G., Hamblin, A.E. J. Allergy Clin. Immunol. (1979) [Pubmed]
  25. Hereditary deficiency of the third component of complement in a child with fever, skin rash, and arthralgias: response to transfusion of whole blood. Osofsky, S.G., Thompson, B.H., Lint, T.F., Gewurz, H. J. Pediatr. (1977) [Pubmed]
  26. Serum complement abnormalities in the antinuclear antibody-positive relatives of children with systemic lupus erythematosus. Lehman, T.J., Hanson, V., Singsen, B.H., Kornreich, H.K., Bernstein, B., King, K.K. Arthritis Rheum. (1979) [Pubmed]
  27. In vitro activation of feline complement by feline leukemia virus. Kobilinsky, L., Hardy, W.D., Ellis, R., Witkin, S.S., Day, N.K. Infect. Immun. (1980) [Pubmed]
  28. Role of immunoglobulin G in killing of Borrelia burgdorferi by the classical complement pathway. Kochi, S.K., Johnson, R.C. Infect. Immun. (1988) [Pubmed]
  29. The absence of detectable complement activation in aspirin-sensitive asthmatic patients during aspirin challenge. Pleskow, W.W., Chenoweth, D.E., Simon, R.A., Stevenson, D.D., Curd, J.G. J. Allergy Clin. Immunol. (1983) [Pubmed]
  30. Complement activation following intravenous contrast material administration. Lieberman, P., Siegle, R.L. J. Allergy Clin. Immunol. (1979) [Pubmed]
  31. Rocket immunoelectrophoresis of C4 and C4d. A simple sensitive method for detecting complement activation in plasma. Nitsche, J.F., Tucker, E.S., Sugimoto, S., Vaughan, J.H., Curd, J.G. Am. J. Clin. Pathol. (1981) [Pubmed]
  32. ELISA for evaluating the incorporation of plasma derived complement split-products C3b/iC3b into solid-phase immune complexes. Zimmermann-Nielsen, E., Svehag, S.E., Thorlacius-Ussing, O., Baatrup, G. J. Immunol. Methods (2001) [Pubmed]
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