Gene Review:
C3 - complement component 3
Homo sapiens
Synonyms:
AHUS5, ARMD9, ASP, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1, C3a, ...
- Weight gain in relation to plasma levels of complement factor 3: results from a population-based cohort study. Engström, G., Hedblad, B., Janzon, L., Lindgärde, F. Diabetologia (2005)
- Relationship between Epstein-Barr virus (EBV)-production and the loss of the EBV receptor/complement receptor complex in a series of sublines derived from the same original Burkitt's lymphoma. Klein, G., Yefenof, E., Falk, K., Westman, A. Int. J. Cancer (1978)
- Variations in the C3, C3a receptor, and C5 genes affect susceptibility to bronchial asthma. Hasegawa, K., Tamari, M., Shao, C., Shimizu, M., Takahashi, N., Mao, X.Q., Yamasaki, A., Kamada, F., Doi, S., Fujiwara, H., Miyatake, A., Fujita, K., Tamura, G., Matsubara, Y., Shirakawa, T., Suzuki, Y. Hum. Genet. (2004)
- Activation of classical pathway complement in chronic inflammation. Elevated levels of circulating C3d and C4d split products in rheumatoid arthritis and Crohn's disease. Petersen, N.E., Elmgreen, J., Teisner, B., Svehag, S.E. Acta medica Scandinavica. (1988)
- Complement C1q and C3 mRNA expression in the frontal cortex of Alzheimer's patients. Fischer, B., Schmoll, H., Riederer, P., Bauer, J., Platt, D., Popa-Wagner, A. J. Mol. Med. (1995)
- Myasthenia gravis. Study of humoral immune mechanisms by passive transfer to mice. Toyka, K.V., Drachman, D.B., Griffin, D.E., Pestronk, A., Winkelstein, J.A., Fishbeck, K.H., Kao, I. N. Engl. J. Med. (1977)
- A novel protein that participates in nonself discrimination of malignant cells by homologous complement. Matsumoto, M., Takeda, J., Inoue, N., Hara, T., Hatanaka, M., Takahashi, K., Nagasawa, S., Akedo, H., Seya, T. Nat. Med. (1997)
- Glycoprotein C of herpes simplex virus 1 acts as a receptor for the C3b complement component on infected cells. Friedman, H.M., Cohen, G.H., Eisenberg, R.J., Seidel, C.A., Cines, D.B. Nature (1984)
- Isolation of a biologically active macrophage receptor for the third component of complement. Schneider, R.J., Kulczycki, A., Law, S.K., Atkinson, J.P. Nature (1981)
- Linkage relationships of the insulin receptor gene with the complement component 3, LDL receptor, apolipoprotein C2 and myotonic dystrophy loci on chromosome 19. Shaw, D.J., Meredith, A.L., Brook, J.D., Sarfarzi, M., Harley, H.G., Huson, S.M., Bell, G.I., Harper, P.S. Hum. Genet. (1986)
- Storage of the complement components C4, C3, and C 3-activator in the human liver as PAS-negative globular hyaline bodies. Storch, W., Riedel, H., Trautmann, B., Justus, J., Hiemann, D. Experimental pathology. (1982)
- Herpes simplex virus glycoproteins gC-1 and gC-2 bind to the third component of complement and provide protection against complement-mediated neutralization of viral infectivity. McNearney, T.A., Odell, C., Holers, V.M., Spear, P.G., Atkinson, J.P. J. Exp. Med. (1987)
- Ionic binding of C3 to the human pathogen Moraxella catarrhalis is a unique mechanism for combating innate immunity. Nordström, T., Blom, A.M., Tan, T.T., Forsgren, A., Riesbeck, K. J. Immunol. (2005)
- Activation of human complement by immunoglobulin G antigranulocyte antibody. Rustagi, P.K., Currie, M.S., Logue, G.L. J. Clin. Invest. (1982)
- The role of complement component C3b and its receptors in sperm-oocyte interaction. Anderson, D.J., Abbott, A.F., Jack, R.M. Proc. Natl. Acad. Sci. U.S.A. (1993)
- C3b2-IgG complexes retain dimeric C3 fragments at all levels of inactivation. Jelezarova, E., Luginbuehl, A., Lutz, H.U. J. Biol. Chem. (2003)
- Dissection of CR1, factor H, membrane cofactor protein, and factor B binding and functional sites in the third complement component. Lambris, J.D., Lao, Z., Oglesby, T.J., Atkinson, J.P., Hack, C.E., Becherer, J.D. J. Immunol. (1996)
- A 34-amino acid peptide of the third component of complement mediates properdin binding. Daoudaki, M.E., Becherer, J.D., Lambris, J.D. J. Immunol. (1988)
- Infection of human thymocytes by Epstein-Barr virus. Watry, D., Hedrick, J.A., Siervo, S., Rhodes, G., Lamberti, J.J., Lambris, J.D., Tsoukas, C.D. J. Exp. Med. (1991)
- Identification of an additional class of C3-binding membrane proteins of human peripheral blood leukocytes and cell lines. Cole, J.L., Housley, G.A., Dykman, T.R., MacDermott, R.P., Atkinson, J.P. Proc. Natl. Acad. Sci. U.S.A. (1985)
- Mapping of the C3d receptor (CR2)-binding site and a neoantigenic site in the C3d domain of the third component of complement. Lambris, J.D., Ganu, V.S., Hirani, S., Müller-Eberhard, H.J. Proc. Natl. Acad. Sci. U.S.A. (1985)
- Interaction of vaccinia virus complement control protein with human complement proteins: factor I-mediated degradation of C3b to iC3b1 inactivates the alternative complement pathway. Sahu, A., Isaacs, S.N., Soulika, A.M., Lambris, J.D. J. Immunol. (1998)
- Expression and characterization of the C345C/NTR domains of complement components C3 and C5. Thai, C.T., Ogata, R.T. J. Immunol. (2003)
- Cleavage of the third complement component (C3) and generation of the spasmogenic peptide, C3a, in human serum via the properdin pathway: demonstration of inhibitory as well as enhancing effects of epsilon-amino-caproic acid. Vogt, W., Schmidt, G., Lynen, R., Dieminger, L. J. Immunol. (1975)
- Analysis of the interactions between properdin, the third component of complement (C3), and its physiological activation products. Farries, T.C., Lachmann, P.J., Harrison, R.A. Biochem. J. (1988)
- Alterations in C3 activation and binding caused by phosphorylation by a casein kinase released from activated human platelets. Ekdahl, K.N., Nilsson, B. J. Immunol. (1999)
- Novel purification scheme and functions for a C3-binding protein from Streptococcus pneumoniae. Cheng, Q., Finkel, D., Hostetter, M.K. Biochemistry (2000)
- Fourth component of Xenopus laevis complement: cDNA cloning and linkage analysis of the frog MHC. Mo, R., Kato, Y., Nonaka, M., Nakayama, K., Takahashi, M. Immunogenetics (1996)
- A protein drp90 encoded on the leftwards strand of soybean nodule urate oxidase cDNA binds to a regulatory sequence in leghemoglobin C3 gene. Bergmann, J.E., Preddie, E., Cortes, L., Brousseau, R. Nucleic Acids Res. (1991)
- Cleavage of the third component of complement (C3) by mannose-binding protein-associated serine protease (MASP) with subsequent complement activation. Matsushita, M., Fujita, T. Immunobiology (1995)
- Proteolysis of C3 on U937 cell plasma membranes. Purification of cathepsin G. Maison, C.M., Villiers, C.L., Colomb, M.G. J. Immunol. (1991)
- CD40 ligand increases complement C3 secretion by proximal tubular epithelial cells. Castellano, G., Cappiello, V., Fiore, N., Pontrelli, P., Gesualdo, L., Schena, F.P., Montinaro, V. J. Am. Soc. Nephrol. (2005)
- Adhesion dependent release of hepatocyte growth factor and interleukin-1 receptor antagonist from human blood granulocytes and monocytes: evidence for the involvement of plasma IgG, complement C3 and beta2 integrin. Takeda, Y., Shiobara, N., Saniabadi, A.R., Adachi, M., Hiraishi, K. Inflamm. Res. (2004)
- Comparative effects of cytokines and cytokine combinations on complement component C3 secretion by HepG2 cells. Andrews, E., Feldhoff, P., Feldhoff, R., Lassiter, H. Cytokine (2003)
- X-ray crystal structure of C3d: a C3 fragment and ligand for complement receptor 2. Nagar, B., Jones, R.G., Diefenbach, R.J., Isenman, D.E., Rini, J.M. Science (1998)
- Serum protein polymorphisms in four populations of Afghanistan. Rahimi, A.G., Goedde, H.W., Flatz, G., Kaifie, S., Benkmann, H.G., Delbrück, H. Am. J. Hum. Genet. (1977)
- Cellular membrane type-1 matrix metalloproteinase (MT1-MMP) cleaves C3b, an essential component of the complement system. Rozanov, D.V., Savinov, A.Y., Golubkov, V.S., Postnova, T.I., Remacle, A., Tomlinson, S., Strongin, A.Y. J. Biol. Chem. (2004)