Disease relevance of Nerve Compression Syndromes

• Important systemic manifestations include acral enlargement, swelling, disfigurement, glucose intolerance and diabetes, hypertension, nerve entrapment, arthropathy, and cardiac disease [1].
• Hereditary neuropathy with liability to pressure palsies (HNPP) is an autosomal-dominant focal neuropathy characterized by recurrent entrapment neuropathies [2].
• In conclusion, we have shown that nerve entrapment is associated with a local intraneural increase in CSPG expression, segmental demyelination, perineurial and endoneurial fibrosis, and other histopathological findings [3].
• Electrodiagnosis has a prominent role in the diagnosis of common entrapment neuropathies (carpal tunnel syndrome and ulnar neuropathy at the elbow) and plexopathies (idiopathic brachial plexopathy and diabetic lumbar radiculoplexopathy) [4].
• Tarsal tunnel syndrome (TTS) is an entrapment neuropathy caused by compression of the posterior tibial nerve beneath the ankle flexor retinaculum [5].

High impact information on Nerve Compression Syndromes

• A consistent feature in both diabetic and control mid lateral plantar nerves was a zone of demyelination that apparently occurs at this natural site of nerve entrapment in rats [6].
• We retrospectively surveyed all electrodiagnostic (EDX) reports of coexisting CTS or UN-E and CRL for anatomic correlation, if any, between the proximal root lesion and the distal entrapment neuropathy [7].
• Posterior interosseous nerve entrapment in rheumatoid arthritis [8].
• Axonal and extracellular matrix responses to experimental chronic nerve entrapment [3].
• The success rate is highest in some entrapment neuropathies but remains low in focal dystonia [9].

Chemical compound and disease context of Nerve Compression Syndromes

• The role of vitamin B6 as a therapeutic agent in the treatment of carpal tunnel syndrome was examined by monitoring both the standard clinical and electrophysiological parameters for entrapment neuropathy at the wrist [10].
• Nerve entrapment was confirmed preoperatively by electrophysiological studies or a positive response to local anesthetic and steroid injection [11].
• Injection of lidocaine around the operation scar gave pain relief to two patients, and one of them had occipital nerve entrapment [12].
• Cyclosporine and entrapment neuropathy. Report of two cases [13].
• Seventy-six patients treated at York Pain Relief Clinic for Abdominal Nerve Entrapment Syndrome (ANES) between 1982 and 1986, using aqueous phenol and nerve stimulator control are reviewed [14].

Biological context of Nerve Compression Syndromes

• BACKGROUND: The authors undertook a study to determine the prevalence in dentists of abnormal sensory nerve conduction and/or symptoms of carpal tunnel syndrome, or CTS, the most common nerve entrapment syndrome [15].

Anatomical context of Nerve Compression Syndromes

• BACKGROUND: Carpal tunnel syndrome (CTS) is an entrapment neuropathy of the median nerve and has been reported after renal transplantation; there are no reports of CTS after liver transplantation [16].
• The two most frequently diagnosed nerve compression syndromes of the upper extremities are carpal tunnel syndrome and cubital tunnel syndrome [17].
• In Part 1 of this two-part series, ligament/muscle strains, nerve entrapment syndromes, and posterior abdominal wall abnormalities are reviewed as common causes of groin pain [18].
• The motor conduction velocity of the ulnar nerve was decreased among patients with CTS supporting the idea that entrapment neuropathies in the hands may be due to tissue swelling caused by vibration at work [19].

Gene context of Nerve Compression Syndromes

• We have analyzed the ultrastructural and histopathological changes that occur during experimental chronic nerve entrapment, as well as the immunohistochemical expression of chondroitin sulfate proteoglycan (CSPG) [3].
• Sixteen patients with nerve entrapment had higher incidence of coma and muscle swelling than the rest of the patients [20].
• Thus, EMG abnormalities were present in many MS patients with no concurrent peripheral or entrapment neuropathies [21].
• Morton's metatarsalgia. Light and electron microscopic observations and their relation to entrapment neuropathies [22].

Analytical, diagnostic and therapeutic context of Nerve Compression Syndromes

• In the differential diagnosis, the exclusion of carpal tunnel syndrome and anterior interosseous nerve entrapment is most important [23].

References