Disease relevance of Hearing Loss, Sudden

• Fifteen of 23 patients had significant hearing loss, of varying types on the tumor side, with one presenting as sudden hearing loss, and another as progressive unilateral sensorineural loss over several years, in the absence, initially, of tinnitus [1].
• The clinical experience gained so far confirms the great therapeutic potential of EBOO in patients with severe peripheral arterial disease, coronary disease, cholesterol embolism, severe dyslipidemia, Madelung disease, and sudden deafness of vascular origin [2].
• We report a patient with definite multiple sclerosis (MS) who developed unilateral sudden hearing loss coincident with exacerbation of central nervous system symptoms [3].
• The clinical presentations and other details of these cases diverge widely, but may represent two emerging syndromes of perilymph fistulas in children: 1. a congenital or hereditary predisposition, and the other, 2. sudden hearing loss in the "good" ear of children with an unexplained sensorineural hearing loss in the opposite ear [4].
• In this study, audiometric tests were administered during 10 hours following glycerol administration in order to determine the long-term effects of glycerol in cases of Meniere's disease, sudden deafness, and normal subjects [5].

High impact information on Hearing Loss, Sudden

• METHODS: Between January, 2000, and June, 2001, we recruited 201 patients with sudden hearing loss from four otorhinolaryngology clinics in Germany. Patients were randomly allocated to single fibrinogen/LDL apheresis or standard treatment (250 mg prednisolone reduced by 25 mg per day, 500 mL 6% hydroxyethyl starch, 400 mg pentoxifylline per day) [6].
• We report a patient with sudden hearing loss who presented with an increased blood glycerol concentration after undergoing an oral glycerol test [7].
• CONCLUSIONS: Sudden hearing loss may occur in about 1% of patients on PEG-IFN/ribavirin combination therapy [8].
• The term sudden hearing loss refers to hearing losses of sensorineural origin that evolve over a short period of time and are often of unknown origin [9].
• Cortisone is used in various inner ear disorders such as sudden hearing loss [10].

Chemical compound and disease context of Hearing Loss, Sudden

• Efficacy of defibrinogenation and steroid therapies on sudden deafness [11].
• Thirty patients with sudden hearing loss were treated with diatrizoate meglumine (Hypaque) and a vasodilator regimen [12].
• Diatrizoate meglumine (Hypaque) treatment for sudden hearing loss [13].
• Carbogen gas for treatment of sudden deafness [14].
• Effectiveness of intratympanic dexamethasone injection in sudden deafness patients as salvage treatment [15].

Biological context of Hearing Loss, Sudden

• Prostaglandin E1, a vasodilator and potent inhibitor of platelet aggregation, was administered by intravenous drip infusion to 51 patients who had sudden deafness [16].
• Carbogen inhalation is recommended for the effective, noninvasive treatment of sudden deafness [17].
• CONCLUSION: The positive reactions to P0 in all bilateral MD and bilateral sudden hearing loss patients found in this study strongly indicate that these pathologies are the result of an ongoing autoimmune process directed against specific antigens of the inner ear [18].

Anatomical context of Hearing Loss, Sudden

• These findings suggest that acute inflammatory demyelinative lesion of the peripheral cochlear nerve can occur in MS, manifesting sudden hearing loss [3].
• Morphological and physiological findings on hair cells with impaired metabolism (nitrogen, monoiodoacetate) in Caiman crocodilus with reference to sudden deafness [19].
• The effects of repeated carbogen inhalation on peripheral tissue perfusion and oxygenation were assessed in 5 patients suffering from sudden hearing loss by means of continuously measured subcutaneous tissue oxygen and carbon dioxide tension, transcutaneous oxygen tension, laser Doppler red cell flux, and fingertip temperature [20].

Gene context of Hearing Loss, Sudden

• We encountered 3 cases of sudden hearing loss associated with IFN [21].
• In this study we investigated the possible relationship between sudden deafness (SD) and IL4R polymorphism Q576R in 97 Korean SD patients and 613 controls using pyrosequencing method [22].
• Compared with the other epidemiological features of Meniere's disease and sudden deafness with vertigo in the same surveys, it appeared that the characteristic features of BPPV are epidemiologically similar to those of Meniere's disease, but different from those of sudden deafness [23].
• In summary, for patients with NF-2, the presentation ages are lower, tumor progression is faster, the chances of anatomic and functional nerve preservation are lower, the chances of good outcomes are best when surgery is performed early and when there is good preoperative hearing function, and the danger of sudden hearing loss is higher [24].
• Intracranial relapse of nasopharyngeal carcinoma manifested as sudden deafness [25].

Analytical, diagnostic and therapeutic context of Hearing Loss, Sudden

• Steroids, carbogen or placebo for sudden hearing loss: a prospective double-blind study [26].
• Besides the well established plasmaphereses and cell depletions, new interesting therapeutic apheresis techniques, e.g. for the treatment of sudden hearing loss and cardiomyopathy, are promising [27].
• Sera from 76 patients with a clinical diagnosis of idiopathic rapidly progressive sensorineural hearing loss (SNHL) (n = 15), sudden deafness (n = 31) and with other etiologies of their hearing loss (n = 30) were analysed by western blot assay [28].

References