Disease relevance of edrophonium

• In difficult cases, an acute apomorphine challenge analogous to the effects of a "Tensilon test" in myasthenia gravis may help to determine whether a given clinical feature represents over- or understimulation of central dopamine receptors [1].
• CONCLUSION: CO2 inhalation is as effective as Tensilon in provoking chest pain in patients with noncardiac chest pain [2].
• The Lancaster test, Bielshowsky head tilt test, double Maddox rod test, fundoscopic examination for torsion, forced duction test, force generation test, tensilon test, thyroid function test, and/or orbit computed tomography were performed when necessary [3].
• A history of variable and fatiguable muscle weakness suggests this diagnosis, which may be confirmed by the edrophonium (Tensilon) test and acetylcholine receptor antibody titer [4].
• Patients with MG whose diplopia was Tensilon unresponsive were only found among those with exophthalmos [5].

High impact information on edrophonium

• TESTING: Serologic evaluation, electromyographic, nerve conduction and Tensilon testing, magnetic resonance and computerized tomographic imaging, and magnetic resonance angiography were performed [6].
• A Tensilon (edrophonium chloride) test, thyroid function test, and orbit computed tomography were performed in 8 patients [7].
• Tensilon test, magnetic resonance imaging, and cerebrospinal fluid analysis were normal [8].
• In a 67-year-old woman with ptosis, double vision, dysphagia, ambiguous Tensilon tests, normal acetylcholine-receptor antibodies, normal thymus, and repeatedly abnormal responses to low-frequency repetitive stimulation, ocular myasthenia was suspected [9].
• Six MG patients were selected on the basis of a positive effect of Tensilon on hypometria of the first saccade [10].

Chemical compound and disease context of edrophonium

• We identified 20 studies of reasonable, although variable, methodological quality upon which to base estimates of the accuracy of the ice test, rest test, Tensilon test, acetylcholine receptor antibodies, repetitive nerve stimulation and single fiber electromyography for the diagnosis of myasthenia gravis [11].
• The preventive effect of Atrovent Dosier-Aerosol on the airway flow resistance (Raw) caused by Tensilon was studied on 10 patients suffering from myasthenia gravis [12].
• A 70-year-old man with known vascular disease, who had bilateral internuclear ophthalmoplegia, and an 18-month-old girl with a long-term variable esotropia culminating in a postinfectious oculopharyngeal neuropathy both responded with a positive edrophonium chloride (Tensilon) test, strongly suggesting the diagnosis of myasthenia gravis [13].
• The neurological state of the infant supported the diagnosis of congenital myasthenia gravis, but the negative Tensilon test and the lack of clinical improvement after prolonged Mestinon treatment ruled out this diagnosis [14].

Biological context of edrophonium

• Intravenous Tensilon resulted in a prompt elevation of the lid and improvement in eye movements [15].
• We assume that tensilon inducing a vagal effect on the anomalous pathway and changes in the heart rate has caused WPW bigeminal pattern [16].
• Myasthenia gravis: the effect of Tensilon on the caloric nystagmus response. Photoelectronystagmographic study [17].

Anatomical context of edrophonium

• This positive effect of Tensilon can mark the alteration of the respiratory muscles and also the undertreatment of the patients [18].
• Phrenic nerve conduction time was normal before and after Tensilon [19].

Associations of edrophonium with other chemical compounds

• Diagnosis is confirmed by electromyography and the edrophonium (Tensilon) test [20].

Analytical, diagnostic and therapeutic context of edrophonium

• Due consideration of clinical symptomatology, a Tensilon test, and a trial of immunosuppression may be necessary to establish the diagnosis [21].
• The tensile and tear strength of carrageenan film from Philippines Eucheuma species were investigated using NEC tensilon universal-testing machine according to American Society for Testing Materials methods [22].
• METHODS: The patients were studied clinically and with various other tests used in OMG diagnosis (SFEMG, repetitive nerve stimulation, Ab anti AChR titration, tensilon test) [23].
• A quantitative Tensilon test yeilded a "perverse" response and a needle biopsy indicated Hashimoto's disease [24].
• After measurement of their baseline phorias and tropias, patients received an intravenous injection of Tensilon via the incremental dose technique until autonomic effects of the drug were noted or until 10 mg was administered [25].

References