Disease relevance of Epididymitis

• RESULTS: Bacterial STD were found in nine participants at enrollment; there were two cases of nonchlamydial urethritis, two cases of nonchlamydial epididymitis, and five cases of asymptomatic GC infection [1].
• Comparative efficacies of ofloxacin, cefotaxime, and doxycycline for treatment of experimental epididymitis due to Escherichia coli in rats [2].
• Antibiotic therapy with tetracycline was effective for the treatment of men with Chlamydia trachomatis epididymitis and should be offered to the female sex partners [3].
• Whereas discontinuing amiodarone risks sudden cardiac death, a reduction in dosage or temporary cessation of the drug may result in rapid resolution of the epididymitis [4].
• In this patient bacteriologic cure was obtained by use of trimethoprim-sulfamethoxazole obviating need for surgical extirpation of the infective focus as had been required in previously reported cases of salmonella epididymitis/orchitis [5].

High impact information on Epididymitis

• Candidal epididymitis treated with ketoconazole [6].
• Non-infectious epididymitis associated with amiodarone therapy [7].
• Following induction of unilateral epididymitis by intratesticular injection of E. coli, a single intraperitoneal dose of amdinocillin, ampicillin, doxycycline, tobramycin, or trimethoprim/sulfamethoxazole was administered to five groups of rats [8].
• Taking oral therapy with trimethoprim-sulfamethoxazole he had recurrent flares of orbital pseudotumor, an episode of orchitis with epididymitis, and persistent polymerase chain reaction T. whipplei-positive cerebrospinal fluid [9].
• RESULTS: Patients with an epididymitis showed at least a 4-fold elevation of CRP except for 2 cases (median 63.2 mg/l) [10].

Chemical compound and disease context of Epididymitis

• The epididymal, testicular, and prostatic tissue penetration of sparfloxacin, a new quinolone, was assessed in a rat model of acute epididymitis [11].
• CONCLUSION: For epididymitis in men over the age of 40 years ciprofloxacin 500 mg orally twice daily is more effective than pivampicillin 700 mg orally twice daily [12].
• OBJECTIVE: To compare the efficacy and safety of ciprofloxacin 500 mg orally twice daily with pivampicillin 700 mg orally twice daily for 10 days in men with acute epididymitis and over 40 years of age [12].
• Seven day regimens of either a tetracycline or erythromycin are generally preferred for uncomplicated infections, but ten days of a tetracycline is preferred for complications like acute pelvic inflammatory disease or epididymitis [13].
• Delayed epididymitis following intravesical bacillus Calmette-Guerin administration [14].

Biological context of Epididymitis

• Conclusions: Acute epididymitis causes an increase of oxidative stress in the ipsilateral and contralateral testes, but this condition is strived for to tolerate the increase of endogenous antioxidants [15].

Gene context of Epididymitis

• Using a cutoff value of IL-6 >/= 1.41 pg/mL, the positive predictive value of IL-6 in diagnosing epididymitis was 78.6%, with a negative predictive value of 100% for TT [16].
• Oxidative and antioxidative status in the testes of rats with acute epididymitis [15].
• Infection generally appeared to be related to the presence of obstruction to the free drainage of the contents of the remnant, and epididymitis occurred where free reflux into the vasa was present [17].
• There were no peri-operative problems and only one patient developed post-operative epididymitis [18].
• I discuss unifying diagnoses for Orwell's respiratory problems and apparent infertility, including tuberculous epididymitis, Young syndrome, immotile cilia syndrome, and cystic fibrosis [19].

Analytical, diagnostic and therapeutic context of Epididymitis

• A double-blind, randomized, controlled multicentre study to compare the efficacy of ciprofloxacin with pivampicillin as oral therapy for epididymitis in men over 40 years of age [12].

References