Disease relevance of Pelvic Inflammatory Disease

• The use of intrauterine devices (IUD) in 690 patients admitted to hospital for pelvic inflammatory disease (PID or acute salpingitis) was compared with the use in a sexually active age-matched control group [1].
• The mean concentrations of plasma M-CSF did not differ in samples from women of different diagnostic groups (normal, peritoneal adhesions, endometriosis, inactive pelvic inflammatory disease, uterine fibroids, and idiopathic infertility), but the PF concentration was slightly higher in normal women [2].
• Using protein fractions, antibody responses of pelvic inflammatory disease (PID) and ectopic pregnancy patients to chlamydial groEL and omp2 were differentiated [3].
• Sera were obtained from men and women with uncomplicated gonorrhea (UGC), women with disseminated gonococcal infection, and women with gonococcal pelvic inflammatory disease (PID); sera were also obtained from uninfected controls [4].
• Of 13 patients (8 with disseminated gonococcal infection, 4 with pelvic inflammatory disease, 1 with gonococcal epididymitis), 12 reacted with protein I antigens and 9 with lipopolysaccharide (LPS) [5].

Psychiatry related information on Pelvic Inflammatory Disease

• The incidence of pelvic inflammatory disease (PID) was low in LNG-IUD users regardless of age, whereas in the Nova T group, the PID rate was increased among the youngest women, which makes the difference between the devices significant (P < 0.01) [6].

High impact information on Pelvic Inflammatory Disease

• To evaluate guidelines for outpatient treatment of acute pelvic inflammatory disease recommended by the Center for Disease Control we studied 197 afflicted women [7].
• Evaluation of tetracycline or penicillin and ampicillin for treatment of acute pelvic inflammatory disease [7].
• Combination treatment is more than twice as cost-effective as tetracycline and seven times as cost-effective as ampicillin when the medical cost of managing pelvic inflammatory disease is considered [8].
• Treatment of pelvic inflammatory disease: use doxycycline with an appropriate beta-lactam while we wait for better data [9].
• Microbial causes of proven pelvic inflammatory disease and efficacy of clindamycin and tobramycin [10].

Chemical compound and disease context of Pelvic Inflammatory Disease

• Therapy for pelvic inflammatory disease must be empirical since it is impossible to distinguish clinically between gonococcal and nongonococcal infection, and our data indicate that both regimens recommended by the Center for Disease Control are effective [7].
• Efficacy of single-agent therapy for the treatment of acute pelvic inflammatory disease with ciprofloxacin [11].
• Sulbactam/ampicillin versus cefoxitin for uncomplicated and complicated acute pelvic inflammatory disease [12].
• A comparison of parenteral sulbactam/ampicillin versus clindamycin/gentamicin in the treatment of pelvic inflammatory disease [13].
• The metronidazole/gentamicin failures included a patient with a tubo-ovarian abscess requiring surgical drainage and 2 patients with pelvic inflammatory disease requiring antichlamydial treatment [14].

Biological context of Pelvic Inflammatory Disease

• CONCLUSIONS: This study demonstrated a significant reduction in post-operative pelvic inflammatory disease in low risk patients, who were applying for legal first trimester abortion, treated peroperatively with ceftriaxone [15].
• Pediatric emergency medicine physicians' compliance with Centers for Disease Control and Prevention's guidelines for treatment of pelvic inflammatory disease [16].
• The effects of cefotetan, cefoxitin, cefazolin, and cefotaxime on polymorphonuclear leukocyte chemotaxis and chemiluminescence were determined in 10 patients with pelvic inflammatory disease and 10 oncologically treated patients [17].
• The purpose of this study was to investigate the occurrence, distribution and frequency of SIN in Danish women salpingectomized because of tubal pregnancy or salpingitis and to correlate SIN with infertility, pregnancies, outcome of pregnancies, births, pelvic inflammatory disease and salpingitis [18].
• Long-term oral contraceptive use confers protection against benign breast disease and colorectal cancer, may help prevent rheumatoid arthritis, decreases ectopic pregnancy and hospitalizations for pelvic inflammatory disease, and helps preserve bone mineral density to reduce risk of fractures [19].

Anatomical context of Pelvic Inflammatory Disease

• The discharge diagnoses for those who had received dimenhydrinate included asthma, pelvic inflammatory disease and urinary tract infection [20].
• Bacterial clearance in the uterine horn and oviduct as a host defense in acute pelvic inflammatory disease was studied in 8- to 12-week-old virgin Balb/c mice [21].
• Fallopian tube damage is a common complication of acute symptomatic pelvic inflammatory disease (PID), yet most women with tubal factor infertility do not have a history of acute PID [22].
• Concentrations of leukotriene B4 (LTB4) and prostaglandin E2 (PGE2) in peritoneal fluid were measured in 19 women with suspected acute pelvic inflammatory disease [23].

Gene context of Pelvic Inflammatory Disease

• Serum CA 125 in acute pelvic inflammatory disease [24].
• Differences in serotype or ompA were not predictive except for an association between serotype F and pelvic inflammatory disease (P=0.046); however, the number of these cases was small [25].
• The convalescent-phase sera of 70% of women with clinically severe pelvic inflammatory disease showed a rise in titer of bactericidal antibody to the infecting strain of N. gonorrhoeae, whereas only 11% of the convalescent-phase sera of women with mild or moderately severe disease showed a similar rise [26].
• We measured tumor-associated trypsin inhibitor (TATI) and C-reactive protein (CRP) in serum of 29 patients with proven pelvic inflammatory disease (PID) [27].
• Antibody to chlamydial hsp60 predicts an increased risk for chlamydial pelvic inflammatory disease [28].

Analytical, diagnostic and therapeutic context of Pelvic Inflammatory Disease

• This multicenter, prospective, double-blind study compared the safety and efficacy of clindamycin and ciprofloxacin versus ceftriaxone and doxycycline in the treatment of outpatients with mild to moderate pelvic inflammatory disease (PID) diagnosed by laparoscopy [29].
• In this study, only 10% of women wearing an IUD were using the Dalkon Shield, yet they accounted for almost 20% of the excess risk of pelvic inflammatory disease occurring among all the IUD users [30].
• The results suggest that intravenous clindamycin alone is a viable alternative to the use of clindamycin/tobramycin for women with acute pelvic inflammatory disease requiring hospitalization [31].
• Prevention of acute pelvic inflammatory disease after hysterosalpingography: efficacy of doxycycline prophylaxis [32].
• METHODS: Women with clinical signs and symptoms of mild-to-moderate pelvic inflammatory disease (n = 831) were randomized into a multicenter trial of inpatient treatment, initially employing intravenous cefoxitin and doxycycline compared with outpatient treatment consisting of a single intramuscular injection of cefoxitin and oral doxycycline [33].

References