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CHURC1  -  churchill domain containing 1

Homo sapiens

Synonyms: C14orf52, CHCH, FLJ33064, My015, Protein Churchill, ...
 
 
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Disease relevance of CHURC1

  • PURPOSE: The Churchill classification system grades the ectopic ureterocele based on the number of renal units in jeopardy [1].
  • Genetic studies of a cluster of acute lymphoblastic leukemia cases in Churchill County, Nevada [2].
  • These data, although not incompatible with the hypothesis of a direct route for action, are better accommodated by the idea of a distributed semantic memory, where different types of knowledge are represented, as proposed by Allport (Allport, D. A. Current perspectives in dysphasia, pp. 32-60. Churchill Livingstone, Edinburgh, 1985) [3].
  • Patients with advanced cancer often develop bone metastases that lead to significant skeletal morbidity and substantially reduced functionality and autonomy [Coleman RE, Rubens RD. Bone metastases. In: Clinical Oncology, 2nd edn. New York: Churchill Livingstone. 2004, p. 1091-128] [4].
  • Thomas's Hospital, London, and the Haemophilia Centre, Churchill Hospital, Oxford. The purpose of the study was to assess the clinical, social, and economic effects of enabling haemophiliacs to treat themselves at home [5].
 

Psychiatry related information on CHURC1

  • Jeanne Lewington was awarded a 1973 Winston Churchill Fellowship to visit the U.S.A. and look at the way volunteers are used, particularly in the field of mental health [6].
 

High impact information on CHURC1

  • Churchill, a zinc finger transcriptional activator, regulates the transition between gastrulation and neurulation [7].
  • Churchill and the immune system of ectothermic vertebrates [8].
  • He subsequently became Prime Minister, succeeding Winston Churchill [9].
  • These replacements are the methyleneamino (CH2NH), the reverse amide (NHCO), the ester (COO), the N-methylamide (CONMe), the thioamide (CSNH), the N-acetylmethyleneamino (CH2NAc), the cis double bond (CHCH), the ethylene (CH2CH2), the thiolester (COS), the hydroxyethylene (CHOHCH2), and a 4,5-dihydro-1,3-thiazole [10].
  • Using the records of Churchill Hospital, Oxford, and those of genetics centres and other national institutions, the minimum prevalence of HD among immigrants from the Indian subcontinent was found to be almost half that found in the indigenous UK population [11].
 

Chemical compound and disease context of CHURC1

 

Biological context of CHURC1

  • Directions in rheumatology: past, present and future. Report of a conference to celebrate the 50th anniversary of the Oliver Bird Fund held at Churchill College Cambridge, 24-26 September 1998 [13].
  • Gene expression profiles in dominant and subordinate animals were compared using a "universal" reference design [Churchill GA (2002) Fundamentals of experimental design for cDNA microarrays. Nat Genet 32 (Suppl):490-495] [14].
  • We recently reported that replacing this tryptophan with glycine creates a buried cavity at the active site that contains ordered solvent and that will specifically bind substituted imidazoles in their protonated cationic forms (Fitzgerald MM, Churchill MJ, McRee DE, Goodin DB, 1994, Biochemistry 33:3807-3818) [15].
  • SETTING: All patients were managed and treated at the Andrology Unit, Churchill Hospital, Oxford, United Kingdom [16].
  • This summarizes a meeting held in London at the Royal Society of Medicine, which was brought together by Prof. Fenella Wojnarowska, Professor of Dermatology at Churchill Hospital, Oxford and cofounder of Skin Care in Organ Recipients, UK (SCOR.UK) [17].
 

Anatomical context of CHURC1

 

Associations of CHURC1 with chemical compounds

  • S. Beale (The Liver. Lecture on the Principles and Practice of Medicine, p 47. London, Churchill, 1889), and they may store and modify bile [20].
  • We report the synthesis and characterization of a series of alkoxy-substituted silylethynylated pentacene derivatives (R = CH(2)CH(2), CHCH, CH(2)) [21].
  • The history of parathyroid surgery, 1850-1996: the Excelsior Surgical Society 1998 Edward D Churchill Lecture [22].
  • Rapid reduction and reemission of mercury deposited into snowpacks during atmospheric mercury depletion events at churchill, Manitoba, Canada [23].
  • Pain Relief in Advanced Cancer; Churchill Livingstone: New York, 1994; 55-61) [24].
 

Other interactions of CHURC1

  • However, operative case volume for PGY1 residents did decrease on the private general surgery service (mean 52 cases per month 02, 43 cases per month 03, p = 0.07), while remaining stable on the Churchill service (mean 23 cases per month 02, 25 cases per month 03, p = 0.66) [25].
  • We also discuss the relationship with an ANOVA model proposed by Churchill et al [26].
  • Given the typically huge population of signals, statistical methods are especially effective at estimation and removal of such technical distortions (Churchill, 2002; Kerr et al., 2000; Yue et al., 2001), as well as providing metrics for computer-based quality control (QC), for example, autoQC (Minor et al., 2002a) [27].
  • METHODS: Prospectively collected departmental coding data for all urological patients attending the Churchill Hospital, Oxford between 1 May 1999 and 30 April 2000 were compared with the coding data entered by hospital coding clerks on the Oxford Radcliffe NHS Trust database [28].
  • Return to TRI: Winston Churchill Fellow and Salford University Scholar travel to Miami and the Keys [29].
 

Analytical, diagnostic and therapeutic context of CHURC1

  • SETTING: Colposcopy and Andrology units at the John Radclife and Churchill Hospitals, Oxford, United Kingdom [30].
  • The application of HPLC with on-line coupled UV/MS-biochemical detection for isolation of an acetylcholinesterase inhibitor from narcissus 'Sir Winston Churchill' [31].
  • Winston Churchill said it best: "Give us the tools and we will finish the job." Industry has provided urologists with the tools in the form of advanced flexible ureteroscopes, the holmium laser, nitinol baskets, and the ureteral access sheath [32].
  • All the information needed to interpret theses traces is included in 'The ECG Made Easy', 5th edition, written by the author and published by Churchill Livingstone [33].
  • The questionnaires were also distributed to control patients who were recruited from the day-surgery unit of the Churchill Hospital. Of 236 questionnaires sent out, 168 replies were analysed; 64 from patients with IBS, 49 from patients with detrusor instability and 55 from controls [34].

References

  1. Ectopic ureterocele: clinical application of classification based on renal unit jeopardy. DeFoor, W., Minevich, E., Tackett, L., Yasar, U., Wacksman, J., Sheldon, C. J. Urol. (2003) [Pubmed]
  2. Genetic studies of a cluster of acute lymphoblastic leukemia cases in Churchill County, Nevada. Steinberg, K.K., Relling, M.V., Gallagher, M.L., Greene, C.N., Rubin, C.S., French, D., Holmes, A.K., Carroll, W.L., Koontz, D.A., Sampson, E.J., Satten, G.A. Environ. Health Perspect. (2007) [Pubmed]
  3. Identification without manipulation: a study of the relations between object use and semantic memory. Moreaud, O., Charnallet, A., Pellat, J. Neuropsychologia. (1998) [Pubmed]
  4. The role of bone markers in metastatic bone disease. Coleman, R.E. Cancer Treat. Rev. (2006) [Pubmed]
  5. Social and psychological responses to home treatment of haemophilia. Kaufert, J.M. Journal of epidemiology and community health. (1980) [Pubmed]
  6. Volunteer case aides in the U.S.A. Lewington, J. The International journal of social psychiatry. (1975) [Pubmed]
  7. Churchill, a zinc finger transcriptional activator, regulates the transition between gastrulation and neurulation. Sheng, G., dos Reis, M., Stern, C.D. Cell (2003) [Pubmed]
  8. Churchill and the immune system of ectothermic vertebrates. Flajnik, M.F. Immunol. Rev. (1998) [Pubmed]
  9. Anthony Eden's (Lord Avon) biliary tract saga. Braasch, J.W. Ann. Surg. (2003) [Pubmed]
  10. Amide bond replacements incorporated into CCK-B selective "dipeptoids". Fincham, C.I., Higginbottom, M., Hill, D.R., Horwell, D.C., O'Toole, J.C., Ratcliffe, G.S., Rees, D.C., Roberts, E. J. Med. Chem. (1992) [Pubmed]
  11. Prevalence of Huntington's disease among UK immigrants from the Indian subcontinent. Shiwach, R.S., Lindenbaum, R.H. The British journal of psychiatry : the journal of mental science. (1990) [Pubmed]
  12. Minocycline as a therapeutic option in bullous pemphigoid. Loo, W.J., Kirtschig, G., Wojnarowska, F. Clin. Exp. Dermatol. (2001) [Pubmed]
  13. Directions in rheumatology: past, present and future. Report of a conference to celebrate the 50th anniversary of the Oliver Bird Fund held at Churchill College Cambridge, 24-26 September 1998. Botting, R., Botting, J. Rheumatology (Oxford, England) (1999) [Pubmed]
  14. Modeling depression: social dominance-submission gene expression patterns in rat neocortex. Kroes, R.A., Panksepp, J., Burgdorf, J., Otto, N.J., Moskal, J.R. Neuroscience (2006) [Pubmed]
  15. The role of aspartate-235 in the binding of cations to an artificial cavity at the radical site of cytochrome c peroxidase. Fitzgerald, M.M., Trester, M.L., Jensen, G.M., McRee, D.E., Goodin, D.B. Protein Sci. (1995) [Pubmed]
  16. A comparison of intrauterine insemination in superovulated cycles to intercourse in couples where the male is receiving steroids for the treatment of autoimmune infertility. Robinson, J.N., Forman, R.G., Nicholson, S.C., Maciocia, L.R., Barlow, D.H. Fertil. Steril. (1995) [Pubmed]
  17. Summary of inaugural meeting of the Skin Care in Organ Recipients Group, UK, held at the Royal Society of Medicine, 7 October 2004. Eedy, D.J. Br. J. Dermatol. (2005) [Pubmed]
  18. Classic pages in Obstetrics and Gynecology. A practical treatise on inflammation, ulceration, and induration of the neck of the uterus: with remarks on the value of leucorrhoea and prolapsus uteri as symptoms of uterine disease: James Henry Bennet, London, John Churchill, 1845. Longo, L.D. Am. J. Obstet. Gynecol. (1979) [Pubmed]
  19. Experimental investigation of the scaphoid strain during wrist motion. Romdhane, L., Chidgey, L., Miller, G., Dell, P. Journal of biomechanics. (1990) [Pubmed]
  20. Hilar biliary plexus in human liver. A comparative study of the intrahepatic bile ducts in man and animals. Yamamoto, K., Fisher, M.M., Phillips, M.J. Lab. Invest. (1985) [Pubmed]
  21. Robust, soluble pentacene ethers. Payne, M.M., Delcamp, J.H., Parkin, S.R., Anthony, J.E. Org. Lett. (2004) [Pubmed]
  22. The history of parathyroid surgery, 1850-1996: the Excelsior Surgical Society 1998 Edward D Churchill Lecture. Organ, C.H. J. Am. Coll. Surg. (2000) [Pubmed]
  23. Rapid reduction and reemission of mercury deposited into snowpacks during atmospheric mercury depletion events at churchill, Manitoba, Canada. Kirk, J.L., St Louis, V.L., Sharp, M.J. Environ. Sci. Technol. (2006) [Pubmed]
  24. Pain in cancer patients unrelated to the cancer or treatment. Marcus, N.J. Cancer Invest. (2005) [Pubmed]
  25. Effect of work-hour reforms on operative case volume of surgical residents. Ferguson, C.M., Kellogg, K.C., Hutter, M.M., Warshaw, A.L. Current surgery. (2005) [Pubmed]
  26. Noise sampling method: an ANOVA approach allowing robust selection of differentially regulated genes measured by DNA microarrays. Draghici, S., Kulaeva, O., Hoff, B., Petrov, A., Shams, S., Tainsky, M.A. Bioinformatics (2003) [Pubmed]
  27. Microarray quality control. Minor, J.M. Meth. Enzymol. (2006) [Pubmed]
  28. Coding errors: a comparative analysis of hospital and prospectively collected departmental data. Khwaja, H.A., Syed, H., Cranston, D.W. BJU international. (2002) [Pubmed]
  29. Return to TRI: Winston Churchill Fellow and Salford University Scholar travel to Miami and the Keys. Stringer, J., Mackereth, P.A. Complementary therapies in nursing & midwifery. (2003) [Pubmed]
  30. Does large loop excision of the transformation zone of the cervix predispose to the development of antisperm antibodies in women? Nicholson, S.C., Robinson, J.N., Sargent, I.L., Hallam, N.F., Charnock, F.M., Barlow, D.H. Fertil. Steril. (1996) [Pubmed]
  31. The application of HPLC with on-line coupled UV/MS-biochemical detection for isolation of an acetylcholinesterase inhibitor from narcissus 'Sir Winston Churchill'. Ingkaninan, K., Hazekamp, A., de Best, C.M., Irth, H., Tjaden, U.R., van der Heijden, R., van der Greef, J., Verpoorte, R. J. Nat. Prod. (2000) [Pubmed]
  32. Ureteral access strategies: pro-access sheath. Vanlangendonck, R., Landman, J. Urol. Clin. North Am. (2004) [Pubmed]
  33. Five men with chest pain. Hampton, J.R. The Practitioner. (1999) [Pubmed]
  34. A case-control study to examine any association between idiopathic detrusor instability and gastrointestinal tract disorder, and between irritable bowel syndrome and urinary tract disorder. Cukier, J.M., Cortina-Borja, M., Brading, A.F. British journal of urology. (1997) [Pubmed]
 
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