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MeSH Review

Pick Disease of the Brain

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Disease relevance of Pick Disease of the Brain


Psychiatry related information on Pick Disease of the Brain


High impact information on Pick Disease of the Brain


Chemical compound and disease context of Pick Disease of the Brain

  • With the exception of rare immunoreactive Pick bodies in one case of Pick's disease, no other structure was recognized by HNE pyrrole adduct antiserum in this series of patients [15].
  • Alterations of muscarinic acetylcholine receptors in atypical Pick's disease without Pick bodies [7].
  • A 61-year-old man with presumed Pick's disease was successfully treated with fluoxetine for pathological affect [16].
  • Sections of formaldehyde-fixed paraffin-embedded cortical and hippocampal brain tissue from five cases with senile dementia of Alzheimer type (SDAT) and five cases with Pick's disease (PD) were immunostained with the monoclonal antibodies (mabs) 147, RT 97, BF 10 and 8D8 with and without pretreatment with alkaline phosphatase (AP) or trypsin (Tr) [17].
  • The water-soluble proteins of the cerebral gray matter and some enzyme systems (cholinesterase, acetylcholinesterase, lactate dehydrogenase, malate dehydrogenase, acid phosphatase) were studied in 9 autopsy cases of Alzheimer's presenile or senile dementia, 1 case of Pick's disease and 1 case of cerebral arteriosclerosis [18].

Biological context of Pick Disease of the Brain


Anatomical context of Pick Disease of the Brain


Gene context of Pick Disease of the Brain


Analytical, diagnostic and therapeutic context of Pick Disease of the Brain

  • OBJECTIVES: To define the cognitive characteristics of Pick disease (PcD), and to determine which features distinguish PcD from Alzheimer disease (AD), in a cross-sectional and longitudinal study [32].
  • Here, PDHc and SDH activity were stimulated with each of the two stereoisomers of alpha lipoic acid in post-mortem parietal brain cortex of patients with DAT, DVT, and one case of Pick's disease and compared to stimulation effects in a control group, matched for age, sex, post-mortem delay, and storage time of brain tissue [33].


  1. Cortical neurons express nerve growth factor receptors in advanced age and Alzheimer disease. Mufson, E.J., Kordower, J.H. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  2. Comparative biochemistry of tau in progressive supranuclear palsy, corticobasal degeneration, FTDP-17 and Pick's disease. Buée, L., Delacourte, A. Brain Pathol. (1999) [Pubmed]
  3. Sporadic Pick's disease: a tauopathy characterized by a spectrum of pathological tau isoforms in gray and white matter. Zhukareva, V., Mann, D., Pickering-Brown, S., Uryu, K., Shuck, T., Shah, K., Grossman, M., Miller, B.L., Hulette, C.M., Feinstein, S.C., Trojanowski, J.Q., Lee, V.M. Ann. Neurol. (2002) [Pubmed]
  4. Which clinical features differentiate progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome) from related disorders? A clinicopathological study. Litvan, I., Campbell, G., Mangone, C.A., Verny, M., McKee, A., Chaudhuri, K.R., Jellinger, K., Pearce, R.K., D'Olhaberriague, L. Brain (1997) [Pubmed]
  5. Pathologic evaluation of the human suprachiasmatic nucleus in severe dementia. Stopa, E.G., Volicer, L., Kuo-Leblanc, V., Harper, D., Lathi, D., Tate, B., Satlin, A. J. Neuropathol. Exp. Neurol. (1999) [Pubmed]
  6. Apolipoprotein E-epsilon4 alleles in cerebral amyloid angiopathy and cerebrovascular pathology associated with Alzheimer's disease. Premkumar, D.R., Cohen, D.L., Hedera, P., Friedland, R.P., Kalaria, R.N. Am. J. Pathol. (1996) [Pubmed]
  7. Alterations of muscarinic acetylcholine receptors in atypical Pick's disease without Pick bodies. Odawara, T., Shiozaki, K., Iseki, E., Hino, H., Kosaka, K. J. Neurol. Neurosurg. Psychiatr. (2003) [Pubmed]
  8. Functional MR in the evaluation of dementia: correlation of abnormal dynamic cerebral blood volume measurements with changes in cerebral metabolism on positron emission tomography with fludeoxyglucose F 18. González, R.G., Fischman, A.J., Guimaraes, A.R., Carr, C.A., Stern, C.E., Halpern, E.F., Growdon, J.H., Rosen, B.R. AJNR. American journal of neuroradiology. (1995) [Pubmed]
  9. Parkinsonism plus syndrome--a review. Mitra, K., Gangopadhaya, P.K., Das, S.K. Neurology India. (2003) [Pubmed]
  10. A novel presenilin 1 mutation associated with Pick's disease but not beta-amyloid plaques. Dermaut, B., Kumar-Singh, S., Engelborghs, S., Theuns, J., Rademakers, R., Saerens, J., Pickut, B.A., Peeters, K., van den Broeck, M., Vennekens, K., Claes, S., Cruts, M., Cras, P., Martin, J.J., Van Broeckhoven, C., De Deyn, P.P. Ann. Neurol. (2004) [Pubmed]
  11. Frontotemporal degeneration, Pick's disease, Pick complex, and Ravel. Kertesz, A., Hillis, A., Munoz, D.G. Ann. Neurol. (2003) [Pubmed]
  12. Variable phenotypic expression and extensive tau pathology in two families with the novel tau mutation L315R. van Herpen, E., Rosso, S.M., Serverijnen, L.A., Yoshida, H., Breedveld, G., van de Graaf, R., Kamphorst, W., Ravid, R., Willemsen, R., Dooijes, D., Majoor-Krakauer, D., Kros, J.M., Crowther, R.A., Goedert, M., Heutink, P., van Swieten, J.C. Ann. Neurol. (2003) [Pubmed]
  13. Brain trace elements in Pick's disease. Ehmann, W.D., Alauddin, M., Hossain, T.I., Markesbery, W.R. Ann. Neurol. (1984) [Pubmed]
  14. Saitohin, which is nested in the tau locus and confers allele-specific susceptibility to several neurodegenerative diseases, interacts with peroxiredoxin 6. Gao, L., Tse, S.W., Conrad, C., Andreadis, A. J. Biol. Chem. (2005) [Pubmed]
  15. 4-hydroxy-2-nonenal pyrrole adducts in human neurodegenerative disease. Montine, K.S., Kim, P.J., Olson, S.J., Markesbery, W.R., Montine, T.J. J. Neuropathol. Exp. Neurol. (1997) [Pubmed]
  16. Reversible intermittent rhythmic myoclonus with fluoxetine in presumed Pick's disease. Lauterbach, E.C. Mov. Disord. (1994) [Pubmed]
  17. Alzheimer dementia and Pick's disease: neurofibrillary tangles and Pick bodies are associated with identical phosphorylated neurofilament epitopes. Ulrich, J., Haugh, M., Anderton, B.H., Probst, A., Lautenschlager, C., His, B. Acta Neuropathol. (1987) [Pubmed]
  18. Some cerebral proteins and enzyme systems in Alzheimer's presenile and senile dementia. Op den Velde, W., Stam, F.C. Journal of the American Geriatrics Society. (1976) [Pubmed]
  19. Familial frontotemporal dementia with ubiquitin-positive, tau-negative inclusions. Kertesz, A., Kawarai, T., Rogaeva, E., St George-Hyslop, P., Poorkaj, P., Bird, T.D., Munoz, D.G. Neurology (2000) [Pubmed]
  20. The p38 pathway is activated in Pick disease and progressive supranuclear palsy: a mechanistic link between mitogenic pathways, oxidative stress, and tau. Hartzler, A.W., Zhu, X., Siedlak, S.L., Castellani, R.J., Avilá, J., Perry, G., Smith, M.A. Neurobiol. Aging (2002) [Pubmed]
  21. Active stress kinase p38 enhances and perpetuates abnormal tau phosphorylation and deposition in Pick's disease. Puig, B., Vinals, F., Ferrer, I. Acta Neuropathol. (2004) [Pubmed]
  22. Structural analysis of Pick's disease-derived and in vitro-assembled tau filaments. King, M.E., Ghoshal, N., Wall, J.S., Binder, L.I., Ksiezak-Reding, H. Am. J. Pathol. (2001) [Pubmed]
  23. The pathology and nosology of primary progressive aphasia. Kertesz, A., Hudson, L., Mackenzie, I.R., Munoz, D.G. Neurology (1994) [Pubmed]
  24. Ectopic expression of Musashi-1 in Alzheimer disease and Pick disease. Lovell, M.A., Markesbery, W.R. J. Neuropathol. Exp. Neurol. (2005) [Pubmed]
  25. Hyperphosphorylated tau proteins differentiate corticobasal degeneration and Pick's disease. Buée Scherrer, V., Hof, P.R., Buée, L., Leveugle, B., Vermersch, P., Perl, D.P., Olanow, C.W., Delacourte, A. Acta Neuropathol. (1996) [Pubmed]
  26. Distribution of basal ganglia lesions in diffuse neurofibrillary tangles with calcification: a clinicopathological study of five autopsy cases. Tsuchiya, K., Nakayama, H., Iritani, S., Arai, T., Niizato, K., Haga, C., Matsushita, M., Ikeda, K. Acta Neuropathol. (2002) [Pubmed]
  27. Differences in tau and apolipoprotein E polymorphism frequencies in sporadic frontotemporal lobar degeneration syndromes. Short, R.A., Graff-Radford, N.R., Adamson, J., Baker, M., Hutton, M. Arch. Neurol. (2002) [Pubmed]
  28. Natively unfolded tubulin polymerization promoting protein TPPP/p25 is a common marker of alpha-synucleinopathies. Kovács, G.G., László, L., Kovács, J., Jensen, P.H., Lindersson, E., Botond, G., Molnár, T., Perczel, A., Hudecz, F., Mezo, G., Erdei, A., Tirián, L., Lehotzky, A., Gelpi, E., Budka, H., Ovádi, J. Neurobiol. Dis. (2004) [Pubmed]
  29. Brain levels of CDK5 activator p25 are not increased in Alzheimer's or other neurodegenerative diseases with neurofibrillary tangles. Tandon, A., Yu, H., Wang, L., Rogaeva, E., Sato, C., Chishti, M.A., Kawarai, T., Hasegawa, H., Chen, F., Davies, P., Fraser, P.E., Westaway, D., St George-Hyslop, P.H. J. Neurochem. (2003) [Pubmed]
  30. Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and related transgenic models. Ferrer, I., Barrachina, M., Puig, B., Martínez de Lagrán, M., Martí, E., Avila, J., Dierssen, M. Neurobiol. Dis. (2005) [Pubmed]
  31. Immunocytochemical colocalization of clusterin in apoptotic photoreceptor cells in retinal degeneration slow rds mutant mouse retinas. Agarwal, N., Jomary, C., Jones, S.E., O'Rourke, K., Chaitin, M., Wordinger, R.J., Murphy, B.F. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  32. Differences between Pick disease and Alzheimer disease in clinical appearance and rate of cognitive decline. Binetti, G., Locascio, J.J., Corkin, S., Vonsattel, J.P., Growdon, J.H. Arch. Neurol. (2000) [Pubmed]
  33. (r)-, but not (s)-alpha lipoic acid stimulates deficient brain pyruvate dehydrogenase complex in vascular dementia, but not in Alzheimer dementia. Frölich, L., Götz, M.E., Weinmüller, M., Youdim, M.B., Barth, N., Dirr, A., Gsell, W., Jellinger, K., Beckmann, H., Riederer, P. Journal of neural transmission (Vienna, Austria : 1996) (2004) [Pubmed]
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