Disease relevance of CCRIS 1327

• When octamethylcyclotetrasiloxane or other single small species of linear and cyclic LMWC of SiO were injected into the rabbit anterior chamber, severe inflammation and corneal edema were induced [1].
• Genetic toxicity evaluation of octamethylcyclotetrasiloxane [2].
• Repeated inhalation exposure to octamethylcyclotetrasiloxane (D4) produces a reversible and dose-related hepatomegaly and proliferation of hepatic endoplasmic reticulum in rats [3].
• Repeated inhalation exposure to octamethylcyclotetrasiloxane produces hepatomegaly, transient hepatic hyperplasia, and sustained hypertrophy in female Fischer 344 rats in a manner similar to phenobarbital [4].

High impact information on CCRIS 1327

• Effect of Octamethylcyclotetrasiloxane on Methylation of Bismuth by Methanosarcina barkeri [5].
• Octamethylcyclotetrasiloxane (OMCTS), a common constituent of household products, triggers the transformation of bismuth to the volatile toxic derivative trimethylbismuth by Methanosarcina barkeri, which is a representative member of the sewage sludge microflora [5].
• We developed a physiologically based pharmacokinetic (PBPK) model to predict the target organ doses of octamethylcyclotetrasiloxane (D(4)) after intravenous (IV), inhalation, or implantation exposures [6].
• Silicone gel and octamethylcyclotetrasiloxane potentiate antibody production to bovine serum albumin in mice [7].
• Inclusion complexes of gamma-cyclodextrin and octamethylcyclotetrasiloxane (D4), decamethyltetrasiloxane (M10TS), and 1,3,5,7-tetramethyltetravinylcyclotetra - siloxane (TMTV-D4) were prepared to compare the cytotoxic effects of siloxanes in vitro [8].

Biological context of CCRIS 1327

• To determine the pharmacokinetics of octamethylcyclotetrasiloxane (D4), a material commonly found in personal care products, the respiratory intake and uptake of D4 were measured in 12 healthy volunteers (25-49 years) on two occasions [9].
• Physiological modeling of inhalation kinetics of octamethylcyclotetrasiloxane in humans during rest and exercise [10].
• Acute respiratory exposure of human volunteers to octamethylcyclotetrasiloxane (D4): absence of immunological effects [11].
• Percutaneous absorption studies of octamethylcyclotetrasiloxane using the human skin/nude mouse model [12].
• Inhalation toxicology of octamethylcyclotetrasiloxane (D4) following a 3-month nose-only exposure in Fischer 344 rats [13].

Anatomical context of CCRIS 1327

• The plasma polymerization of hexamethylcyclotrisiloxane (D3) and octamethylcyclotetrasiloxane (D4) over the microporous polypropylene membrane Celgard 2400, over polypropylene filter membranes, and over glass slides was investigated [14].

Associations of CCRIS 1327 with other chemical compounds

• The solvation force profiles of squalane/octamethylcyclotetrasiloxane (OMCTS) mixtures confined between Si3N4 tips and highly oriented pyrolytic graphite (HOPG) and hexadecane/OMCTS confined between alkanethiol-functionalized tips and freshly cleaved mica have been measured by atomic force microscopy [15].
• The transport of octamethylcyclotetrasiloxane (D4), one of the major constituents of silicone fluids and rubbers, and low viscosity polydimethylsiloxane oil into a silica filled cross-linked silicone elastomeric rubber was measured as a function of temperature, cross-link density of the rubber, and concentration of the D4 in methanol solution [16].

Gene context of CCRIS 1327

• Octamethylcyclotetrasiloxane exhibits estrogenic activity in mice via ERalpha [17].
• The purpose of the present study is to determine whether components of the silicone breast implant (silicone oil, silicone gel, and octamethylcyclotetrasiloxane [D4]) potentiate the antibody response to BSA in mice [7].
• Evaluation of octamethylcyclotetrasiloxane (D4) as an inducer of rat hepatic microsomal cytochrome P450, UDP-glucuronosyltransferase, and epoxide hydrolase: a 28-day inhalation study [3].

References