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MeSH Review

Corneal Edema

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Disease relevance of Corneal Edema


High impact information on Corneal Edema

  • Biomicroscopic and histologic examination of bFGF- and VEGF-induced angiogenesis was notable for the absence of corneal edema or substantial inflammation [6].
  • Corneal edema recovery dynamics in diabetes: is the alloxan induced diabetic rabbit a useful model [7]?
  • When octamethylcyclotetrasiloxane or other single small species of linear and cyclic LMWC of SiO were injected into the rabbit anterior chamber, severe inflammation and corneal edema were induced [8].
  • The critical hydrogel lens oxygen transmissibility needed to limit overnight corneal edema to 4% (the level experienced without a contact lens in place) was found to be 87.0 +/- 3.3 X 10(-9) (cm X ml O2)/(sec X ml X mmHg)--an EOP of 17.9% [9].
  • Phenylephrine may therefore be implicated as a causative factor of corneal edema and postoperative inflammation [10].

Chemical compound and disease context of Corneal Edema

  • Recent reports suggest that the aphakic eye develops less corneal edema than the phakic eye during hydrogel contact lens wear [11].
  • Using a rabbit model, the effects of trifluridine (F3TdR) on corneal edema and stromal disease were examined when combined with each of three immunosuppressive agents [1].
  • RESULTS: A 3-week course of topical steroid treatment resulted in a dramatic improvement in the stromal corneal edema and regression of the deep stromal vascularization [12].
  • There was no change in the corneal edema with the injection of sodium hyaluronate 1.4% (Healon GV as a control [13].
  • No untoward reaction to the fluorescein was observed; however, the long ultrasound exposure for very hard nuclei (up to 4 minutes) caused corneal edema in two eyes [14].

Biological context of Corneal Edema


Anatomical context of Corneal Edema


Gene context of Corneal Edema

  • Possible side effects of tPA injection, such as increased intraocular pressure and corneal edema, were not observed [22].
  • METHODS: We induced hypoxic corneal edema and measured corneal deswelling (expressed as percent recovery per hour, PRPH, over 7 hours) with a modified optical pachometer in 12 corneas of 8 patients transplanted 7-18 years previously and in 21 normal adult control subjects [23].
  • An early manifestation of posterior polymorphous dystrophy with corneal edema present at birth or soon thereafter is extremely rare; only a few ultrastructural reports are available [24].
  • Permanent corneal edema resulting from the treatment of PTK corneal haze with mitomycin: a case report [25].
  • In eyes treated with a cyclooxygenase inhibitor the period of neovascularization was slightly shortened and corneal edema decreased [26].

Analytical, diagnostic and therapeutic context of Corneal Edema


  1. Therapeutic response of herpes simplex virus-induced corneal edema to trifluridine in combination with immunosuppressive agents. O'Brien, W.J., Taylor, J.L. Invest. Ophthalmol. Vis. Sci. (1991) [Pubmed]
  2. Flurbiprofen 0.03% for the control of inflammation following cataract extraction by phacoemulsification. Blaydes, J.E., Kelley, E.P., Walt, J.G., DeGryse, R.E., Harper, D.G., Novack, G.D. Journal of cataract and refractive surgery. (1993) [Pubmed]
  3. A synopsis of extended-wear lenses and lens care regimens. Lowther, G.E. Optometry clinics : the official publication of the Prentice Society. (1991) [Pubmed]
  4. Comparison of iris fixation and anterior chamber intraocular lens implants. MacInnis, B.J., Shirley, S.Y., Valberg, J.D., Gaukrodger, W.T. Can. J. Ophthalmol. (1983) [Pubmed]
  5. The effect of 0.1% Indomethacin eyedrops on cataract surgery. Liou, S.W., Yen, R.J. Journal of ocular pharmacology. (1991) [Pubmed]
  6. A model of angiogenesis in the mouse cornea. Kenyon, B.M., Voest, E.E., Chen, C.C., Flynn, E., Folkman, J., D'Amato, R.J. Invest. Ophthalmol. Vis. Sci. (1996) [Pubmed]
  7. Corneal edema recovery dynamics in diabetes: is the alloxan induced diabetic rabbit a useful model? Herse, P., Hooker, B. Invest. Ophthalmol. Vis. Sci. (1994) [Pubmed]
  8. Ocular toxicity of low-molecular-weight components of silicone and fluorosilicone oils. Nakamura, K., Refojo, M.F., Crabtree, D.V., Pastor, J., Leong, F.L. Invest. Ophthalmol. Vis. Sci. (1991) [Pubmed]
  9. Critical oxygen levels to avoid corneal edema for daily and extended wear contact lenses. Holden, B.A., Mertz, G.W. Invest. Ophthalmol. Vis. Sci. (1984) [Pubmed]
  10. Effect of phenylephrine on normal and regenerated endothelial cells in cat cornea. Cohen, K.L., Van Horn, D.L., Edelhauser, H.F., Schultz, R.O. Invest. Ophthalmol. Vis. Sci. (1979) [Pubmed]
  11. Effects of cataract surgery on corneal function. Holden, B.A., Polse, K.A., Fonn, D., Mertz, G.W. Invest. Ophthalmol. Vis. Sci. (1982) [Pubmed]
  12. Neurotrophic corneal endothelial failure complicating acute Horner syndrome. Zamir, E., Chowers, I., Banin, E., Frucht-Pery, J. Ophthalmology (1999) [Pubmed]
  13. Using medical lubricating jelly in human cadaver eyes to teach ophthalmic surgery. Liu, E.S., Eng, K.T., Braga-Mele, R. Journal of cataract and refractive surgery. (2001) [Pubmed]
  14. Fluorescein blue, light-assisted capsulorhexis for mature or hypermature cataract. Fritz, W.L. Journal of cataract and refractive surgery. (1998) [Pubmed]
  15. The effect of intracameral ethacrynic acid on the intraocular pressure of living monkeys. Tingey, D.P., Ozment, R.R., Schroeder, A., Epstein, D.L. Am. J. Ophthalmol. (1992) [Pubmed]
  16. Clinical performance of two opaque, tinted soft contact lenses. Gauthier, C.A., Grant, T., Holden, B.A. Journal of the American Optometric Association. (1992) [Pubmed]
  17. Corneal endothelial cell protection with a dispersive viscoelastic material and an irrigating solution during phacoemulsification: low-cost versus expensive combination. Kiss, B., Findl, O., Menapace, R., Petternel, V., Wirtitsch, M., Lorang, T., Gengler, M., Drexler, W. Journal of cataract and refractive surgery. (2003) [Pubmed]
  18. Familial spinocerebellar degeneration with corneal dystrophy. Der Kaloustian, V.M., Jarudi, N.I., Khoury, M.J., Afifi, A.K., Bahuth, N.B., Deeb, M.E., Shammas, J., Mikati, M.A. Am. J. Med. Genet. (1985) [Pubmed]
  19. Endothelial cell repopulation after intracameral acetic acid irrigation. Stoneburner, S., Thresher, R., Cobo, L.M., Klintworth, G.K. Graefes Arch. Clin. Exp. Ophthalmol. (1985) [Pubmed]
  20. Extracellular matrix and Na+,K+-ATPase in human corneas following cataract surgery: comparison with bullous keratopathy and Fuchs' dystrophy corneas. Ljubimov, A.V., Atilano, S.R., Garner, M.H., Maguen, E., Nesburn, A.B., Kenney, M.C. Cornea (2002) [Pubmed]
  21. Thermal modeling of millimeter wave damage to the primate cornea at 35 GHz and 94 GHz. Foster, K.R., D'Andrea, J.A., Chalfin, S., Hatcher, D.J. Health physics. (2003) [Pubmed]
  22. Treatment of total hyphema with relatively low-dose tissue plasminogen activator. Kim, M.H., Koo, T.H., Sah, W.J., Chung, S.M. Ophthalmic surgery and lasers. (1998) [Pubmed]
  23. Functional measurements on the enlarged endothelial cells of corneal transplants. Bourne, W.M. Transactions of the American Ophthalmological Society. (1995) [Pubmed]
  24. An ultrastructural investigation of an early manifestation of the posterior polymorphous dystrophy of the cornea. Sekundo, W., Lee, W.R., Kirkness, C.M., Aitken, D.A., Fleck, B. Ophthalmology (1994) [Pubmed]
  25. Permanent corneal edema resulting from the treatment of PTK corneal haze with mitomycin: a case report. Pfister, R.R. Cornea (2004) [Pubmed]
  26. Modulation of immunogenic keratitis in rabbits by topical administration of inhibitors of lipoxygenase and cyclooxygenase. Verbey, N.L., van Haeringen, N.J., de Jong, P.T. Curr. Eye Res. (1988) [Pubmed]
  27. Traumatic endophthalmitis caused by an Erwinia species. Mason, G.I., Bottone, E.J., Podos, S.M. Am. J. Ophthalmol. (1976) [Pubmed]
  28. Reversible amantadine-induced corneal edema in an adolescent. Hughes, B., Feiz, V., Flynn, S.B., Brodsky, M.C. Cornea (2004) [Pubmed]
  29. Dorzolamide and corneal recovery from edema in patients with glaucoma or ocular hypertension. Giasson, C.J., Nguyen, T.Q., Boisjoly, H.M., Lesk, M.R., Amyot, M., Charest, M. Am. J. Ophthalmol. (2000) [Pubmed]
  30. Oxygen-transmitting hard contact lenses. Mandell, R. Journal of the American Optometric Association. (1979) [Pubmed]
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