Disease relevance of Corneal Edema

• Therapeutic response of herpes simplex virus-induced corneal edema to trifluridine in combination with immunosuppressive agents [1].
• The flurbiprofen group had significantly less anterior chamber cells and flare at day 7 and significantly less conjunctival erythema, corneal edema, and lid edema at day 14 [2].
• The clinical properties of hydrogel and rigid gas-permeable contact lenses for extended wear are examined, with emphasis on oxygen permeability and transmissibility, so that clinicians may select lenses likely to minimize corneal edema or may predict the amount of edema likely with a given lens [3].
• The visual results were equivalent with the two types of lens, but cystoid macular edema, corneal edema, uveitis, steroid-induced ocular hypertension and lens dislocation were more frequent among the 176 eyes with iris fixation lenses [4].
• The results revealed that topical use of 0.1% Indomethacin eyedrops could prevent intraoperative miosis and reduce postoperative corneal edema and anterior chamber reaction, but it did not show much influence on intraocular pressure [5].

High impact information on Corneal Edema

• Biomicroscopic and histologic examination of bFGF- and VEGF-induced angiogenesis was notable for the absence of corneal edema or substantial inflammation [6].
• Corneal edema recovery dynamics in diabetes: is the alloxan induced diabetic rabbit a useful model [7]?
• When octamethylcyclotetrasiloxane or other single small species of linear and cyclic LMWC of SiO were injected into the rabbit anterior chamber, severe inflammation and corneal edema were induced [8].
• The critical hydrogel lens oxygen transmissibility needed to limit overnight corneal edema to 4% (the level experienced without a contact lens in place) was found to be 87.0 +/- 3.3 X 10(-9) (cm X ml O2)/(sec X ml X mmHg)--an EOP of 17.9% [9].
• Phenylephrine may therefore be implicated as a causative factor of corneal edema and postoperative inflammation [10].

Chemical compound and disease context of Corneal Edema

• Recent reports suggest that the aphakic eye develops less corneal edema than the phakic eye during hydrogel contact lens wear [11].
• Using a rabbit model, the effects of trifluridine (F3TdR) on corneal edema and stromal disease were examined when combined with each of three immunosuppressive agents [1].
• RESULTS: A 3-week course of topical steroid treatment resulted in a dramatic improvement in the stromal corneal edema and regression of the deep stromal vascularization [12].
• There was no change in the corneal edema with the injection of sodium hyaluronate 1.4% (Healon GV as a control [13].
• No untoward reaction to the fluorescein was observed; however, the long ultrasound exposure for very hard nuclei (up to 4 minutes) caused corneal edema in two eyes [14].

Biological context of Corneal Edema

• Concentrations of ethacrynic acid less than 3.0 mmol/l did not provide reliable reduction of intraocular pressure, whereas concentrations greater than 3.75 mmol/l caused a greater incidence and severity of corneal edema [15].
• Comfort, visual acuity, visual fields, daytime corneal edema and corneal staining were evaluated on 22 subjects wearing opaque tinted and non-opaque control hydrogel lenses [16].

Anatomical context of Corneal Edema

• CONCLUSIONS: During phacoemulsification in a nonselected patient population, there was no difference in acute postoperative corneal edema and endothelial cell morphology after 3 months between a Viscoat and BSS Plus combination and an Ocucoat and Ringer's solution combination [17].
• Histologic examination showed findings of corneal dystrophy including corneal edema, thickening of Descemet membrane, and degenerative pannus [18].
• Since postsurgical corneal edema generally indicates corneal endothelial dysfunction, the effects of acetic acid on corneal endothelium were studied in the cat where the endothelial regenerative capacity is thought to be comparable to that of humans [19].
• CONCLUSIONS: Because tenascin-C and fibrillin-1 were mostly found in diseased but not in PCS corneas, their expression may be related to later, clinical stages of corneal edema development [20].
• The thresholds for damage to the cornea (staining of the corneal epithelium by fluorescein and corneal edema) correspond to temperature increases of about 20 degrees C at both irradiation frequencies [21].

Gene context of Corneal Edema

• Possible side effects of tPA injection, such as increased intraocular pressure and corneal edema, were not observed [22].
• METHODS: We induced hypoxic corneal edema and measured corneal deswelling (expressed as percent recovery per hour, PRPH, over 7 hours) with a modified optical pachometer in 12 corneas of 8 patients transplanted 7-18 years previously and in 21 normal adult control subjects [23].
• An early manifestation of posterior polymorphous dystrophy with corneal edema present at birth or soon thereafter is extremely rare; only a few ultrastructural reports are available [24].
• Permanent corneal edema resulting from the treatment of PTK corneal haze with mitomycin: a case report [25].
• In eyes treated with a cyclooxygenase inhibitor the period of neovascularization was slightly shortened and corneal edema decreased [26].

Analytical, diagnostic and therapeutic context of Corneal Edema

• The similarity between corneal edema recovery rates in the human subject with type 1 diabetes and the alloxan-induced diabetic rabbit supports the use of the alloxan-induced diabetic rabbit as an animal model for studies of corneal edema recovery dynamics in diabetes [7].
• Thirty-seven days after a course of cefazolin and gentamicin therapy, corneal edema necessitated a planned extracapsular cataract extraction [27].
• Amantadine can cause corneal decompensation and needs to be considered as part of the differential diagnosis of corneal edema [28].
• One subject developed persistent corneal edema after his stress test in the eye treated with dorzolamide [29].
• Nine PMMA contact lens wearers with persistent corneal edema were refitted with CAB contact lenses [30].

References