The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

BOF 4272     sodium7-[3-methoxy-4- (phenylsulfinyl)phen...

Synonyms:
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of 7-[4-(benzenesulfinyl)-3-methoxy-phenyl]-1,3,5,9-tetrazabicyclo[4.3.0]nona-3,5,7-trien-2-one

  • BOF-4272, (+/-)-8-(3-methoxy-4- phenylsulfinylphenyl)pyrazolo[1,5-a]-1,3,5-triazine-4(1H)-one, is a new drug intended for the treatment of hyperuricemia [1].
 

High impact information on 7-[4-(benzenesulfinyl)-3-methoxy-phenyl]-1,3,5,9-tetrazabicyclo[4.3.0]nona-3,5,7-trien-2-one

 

Biological context of 7-[4-(benzenesulfinyl)-3-methoxy-phenyl]-1,3,5,9-tetrazabicyclo[4.3.0]nona-3,5,7-trien-2-one

 

Anatomical context of 7-[4-(benzenesulfinyl)-3-methoxy-phenyl]-1,3,5,9-tetrazabicyclo[4.3.0]nona-3,5,7-trien-2-one

  • Furthermore, the influx of BOF-4272 into hepatocytes occurred in a temperature-dependent manner [6].
  • 6. M2, which is the demethylated form of BOF-4269, was detected in faeces after the oral administration of BOF-4272 to rat in which the common bile duct was cannulated, suggesting that BOF-4272 is metabolized to BOF-4269 and then to M2 by the intestinal flora [9].
  • Thus, the enantioselectivity in the hepatic local disposition of BOF-4272 was compared between R- and S-enantiomers by a hepatic perfusion experiment with a pulse input into the portal vein [10].
  • The metabolic pathways were investigated using the metabolites found in plasma, urine, and feces after intravenous or oral administration of BOF-4272, as well as the metabolites found in the liver S9 incubation mixture after the addition of BOF-4272 or BOF-4269 [1].
  • The elution time profile of each BOF-4272 enantiomer from the liver into the hepatic vein was measured at four different bovine serum albumin (BSA) concentrations (0, 0.25, 1.0 and 4.0%) in the perfusate at 37 and 4 degrees C. A crossover test was carried out for R- and S-enantiomers using one rat liver [10].
 

Associations of 7-[4-(benzenesulfinyl)-3-methoxy-phenyl]-1,3,5,9-tetrazabicyclo[4.3.0]nona-3,5,7-trien-2-one with other chemical compounds

 

Gene context of 7-[4-(benzenesulfinyl)-3-methoxy-phenyl]-1,3,5,9-tetrazabicyclo[4.3.0]nona-3,5,7-trien-2-one

 

Analytical, diagnostic and therapeutic context of 7-[4-(benzenesulfinyl)-3-methoxy-phenyl]-1,3,5,9-tetrazabicyclo[4.3.0]nona-3,5,7-trien-2-one

References

  1. Metabolic pathways and pharmacokinetics of BOF-4272, a sulfoxide-containing drug, in the dog: in vivo and in vitro studies. Naito, S., Nishimura, M., Yoshitsugu, H., Nogawa, H. Biol. Pharm. Bull. (1999) [Pubmed]
  2. Xanthine oxidase inhibition attenuates kupffer cell production of neutrophil chemoattractant following ischemia-reperfusion in rat liver. Matsumura, F., Yamaguchi, Y., Goto, M., Ichiguchi, O., Akizuki, E., Matsuda, T., Okabe, K., Liang, J., Ohshiro, H., Iwamoto, T., Yamada, S., Mori, K., Ogawa, M. Hepatology (1998) [Pubmed]
  3. Xanthine oxidase inhibitors suppress testicular germ cell apoptosis induced by experimental cryptorchidism. Kumagai, A., Kodama, H., Kumagai, J., Fukuda, J., Kawamura, K., Tanikawa, H., Sato, N., Tanaka, T. Mol. Hum. Reprod. (2002) [Pubmed]
  4. In vitro and in vivo studies on the stereoselective pharmacokinetics and biotransformation of an (S)-(-)- and (R)-(+)-pyrazolotriazine sulfoxide in the male rat. Naito, S., Nishimura, M. Xenobiotica (2002) [Pubmed]
  5. Pharmacokinetics of BOF-4272, a xanthine oxidase inhibitor, after single intravenous or oral administration to male mice and rats. Naito, S., Nishimura, M., Nogawa, H. J. Pharm. Pharmacol. (1999) [Pubmed]
  6. Evaluation of the pharmacological actions and pharmacokinetics of BOF-4272, a xanthine oxidase inhibitor, in mouse liver. Naito, S., Nishimura, M., Tamao, Y. J. Pharm. Pharmacol. (2000) [Pubmed]
  7. Hepatic local disposition of a drug with high protein binding and high hepatic clearance using BOF-4272 as a model drug. Nishimura, M., Yamaoka, K., Naito, S., Nakagawa, T. Biol. Pharm. Bull. (1996) [Pubmed]
  8. Enantioselective uptake of BOF-4272, a xanthine oxidase inhibitor with a chiral sulfoxide, by isolated rat hepatocytes. Naito, S., Nishimura, M. Yakugaku Zasshi (2001) [Pubmed]
  9. Biotransformation of the xanthine oxidase inhibitor BOF-4272 and its metabolites in the liver and by the intestinal flora in rat. Naito, S., Nishimura, M. Xenobiotica (2000) [Pubmed]
  10. Influence of albumin on enantioselective local disposition of BOF-4272, a xanthine oxidase inhibitor with chiral sulfoxide, in rat liver. Nishimura, M., Yamaoka, K., Naito, S., Nakagawa, T. Biol. Pharm. Bull. (1997) [Pubmed]
  11. Biotransformation of BOF-4272, a sulfoxide-containing drug, in the cynomolgus monkey. Naito, S., Nishimura, M., Jin, Y. European journal of drug metabolism and pharmacokinetics. (1999) [Pubmed]
  12. Local disposition of a new xanthine oxidase/xanthine dehydrogenase inhibitor, BOF-4272, in rat liver. Nishimura, M., Yamaoka, K., Yasui, H., Naito, S., Nakagawa, T. Biol. Pharm. Bull. (1994) [Pubmed]
  13. A novel xanthine dehydrogenase inhibitor (BOF-4272). Sato, S., Tatsumi, K., Nishino, T. Adv. Exp. Med. Biol. (1991) [Pubmed]
  14. Stereoselective pharmacokinetics of BOF-4272 racemate after oral administration to rats and dogs. Naito, S., Nishimura, M. Biol. Pharm. Bull. (2002) [Pubmed]
 
WikiGenes - Universities