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Chemical Compound Review

Rapiacta     (1S,2S,3S,4R)-3-[(1S)-1- acetamido-2-ethyl...

Synonyms: PeramiFlu, Peramivir, CHEMBL139367, SureCN744373, BCX-1812, ...
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Disease relevance of AIDS-114230


High impact information on AIDS-114230


Chemical compound and disease context of AIDS-114230


Biological context of AIDS-114230


Anatomical context of AIDS-114230


Associations of AIDS-114230 with other chemical compounds


Gene context of AIDS-114230

  • Pharmacodynamic evaluation of RWJ-270201, a novel neuraminidase inhibitor, in a lethal murine model of influenza predicts efficacy for once-daily dosing [17].

Analytical, diagnostic and therapeutic context of AIDS-114230


  1. Efficacy and tolerability of the oral neuraminidase inhibitor peramivir in experimental human influenza: randomized, controlled trials for prophylaxis and treatment. Barroso, L., Treanor, J., Gubareva, L., Hayden, F.G. Antivir. Ther. (Lond.) (2005) [Pubmed]
  2. Comparison of the activities of zanamivir, oseltamivir, and RWJ-270201 against clinical isolates of influenza virus and neuraminidase inhibitor-resistant variants. Gubareva, L.V., Webster, R.G., Hayden, F.G. Antimicrob. Agents Chemother. (2001) [Pubmed]
  3. In vivo influenza virus-inhibitory effects of the cyclopentane neuraminidase inhibitor RJW-270201. Sidwell, R.W., Smee, D.F., Huffman, J.H., Barnard, D.L., Bailey, K.W., Morrey, J.D., Babu, Y.S. Antimicrob. Agents Chemother. (2001) [Pubmed]
  4. Accumulation of defective neuraminidase (NA) genes by influenza A viruses in the presence of NA inhibitors as a marker of reduced dependence on NA. Nedyalkova, M.S., Hayden, F.G., Webster, R.G., Gubareva, L.V. J. Infect. Dis. (2002) [Pubmed]
  5. Comparison of efficacies of RWJ-270201, zanamivir, and oseltamivir against H5N1, H9N2, and other avian influenza viruses. Govorkova, E.A., Leneva, I.A., Goloubeva, O.G., Bush, K., Webster, R.G. Antimicrob. Agents Chemother. (2001) [Pubmed]
  6. Susceptibilities of antiviral-resistant influenza viruses to novel neuraminidase inhibitors. Mishin, V.P., Hayden, F.G., Gubareva, L.V. Antimicrob. Agents Chemother. (2005) [Pubmed]
  7. Oral administration of cyclopentane neuraminidase inhibitors protects ferrets against influenza virus infection. Sweet, C., Jakeman, K.J., Bush, K., Wagaman, P.C., McKown, L.A., Streeter, A.J., Desai-Krieger, D., Chand, P., Babu, Y.S. Antimicrob. Agents Chemother. (2002) [Pubmed]
  8. Cyclopentane neuraminidase inhibitors with potent in vitro anti-influenza virus activities. Smee, D.F., Huffman, J.H., Morrison, A.C., Barnard, D.L., Sidwell, R.W. Antimicrob. Agents Chemother. (2001) [Pubmed]
  9. Evaluation of methyl inosine monophosphate (MIMP) and peramivir activities in a murine model of lethal influenza A virus infection. Mishin, V.P., Hayden, F.G., Signorelli, K.L., Gubareva, L.V. Antiviral Res. (2006) [Pubmed]
  10. Combination treatment of influenza A virus infections in cell culture and in mice with the cyclopentane neuraminidase inhibitor RWJ-270201 and ribavirin. Smee, D.F., Bailey, K.W., Morrison, A.C., Sidwell, R.W. Chemotherapy. (2002) [Pubmed]
  11. BCX-1812 (RWJ-270201): discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design. Babu, Y.S., Chand, P., Bantia, S., Kotian, P., Dehghani, A., El-Kattan, Y., Lin, T.H., Hutchison, T.L., Elliott, A.J., Parker, C.D., Ananth, S.L., Horn, L.L., Laver, G.W., Montgomery, J.A. J. Med. Chem. (2000) [Pubmed]
  12. Population analysis of the pharmacokinetics and pharmacodynamics of RWJ-270201 (BCX-1812) in treating experimental influenza A and B virus in healthy volunteers. Iyer, G.R., Liao, S., Massarella, J. AAPS PharmSci (2002) [Pubmed]
  13. A point mutation in influenza B neuraminidase confers resistance to peramivir and loss of slow binding. Baum, E.Z., Wagaman, P.C., Ly, L., Turchi, I., Le, J., Bucher, D., Bush, K. Antiviral Res. (2003) [Pubmed]
  14. Characterization of multidrug-resistant influenza A/H3N2 viruses shed during 1 year by an immunocompromised child. Baz, M., Abed, Y., McDonald, J., Boivin, G. Clin. Infect. Dis. (2006) [Pubmed]
  15. Primary immune system effects of the orally administered cyclopentane neuraminidase inhibitor RWJ-270201 in influenza virus-infected mice. Sidwell, R.W., Smee, D.F., Bailey, K.W., Burger, R.A. Int. Immunopharmacol. (2001) [Pubmed]
  16. Comparison of the anti-influenza virus activity of RWJ-270201 with those of oseltamivir and zanamivir. Bantia, S., Parker, C.D., Ananth, S.L., Horn, L.L., Andries, K., Chand, P., Kotian, P.L., Dehghani, A., El-Kattan, Y., Lin, T., Hutchison, T.L., Montgomery, J.A., Kellog, D.L., Babu, Y.S. Antimicrob. Agents Chemother. (2001) [Pubmed]
  17. Pharmacodynamic evaluation of RWJ-270201, a novel neuraminidase inhibitor, in a lethal murine model of influenza predicts efficacy for once-daily dosing. Drusano, G.L., Preston, S.L., Smee, D., Bush, K., Bailey, K., Sidwell, R.W. Antimicrob. Agents Chemother. (2001) [Pubmed]
  18. Anti-influenza virus activity of peramivir in mice with single intramuscular injection. Bantia, S., Arnold, C.S., Parker, C.D., Upshaw, R., Chand, P. Antiviral Res. (2006) [Pubmed]
  19. Identification of a human influenza type B strain with reduced sensitivity to neuraminidase inhibitor drugs. Hurt, A.C., McKimm-Breschkin, J.L., McDonald, M., Barr, I.G., Komadina, N., Hampson, A.W. Virus Res. (2004) [Pubmed]
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