The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Clomifen     2-[4-[(Z)-2-chloro-1,2- diphenyl...

Synonyms: Clomifene, clomiphene, Enclomifene, Enclomiphen, Zuclomifene, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Clomifene


High impact information on Clomifene

  • Similarly the relative potency of estrogens to stimulate prolactin synthesis was diethylstilbestrol identical to estradiol greater than ICI 77,949 greater than ICI 47,699 identical to zuclomiphene, consistent with their RBAs [2].
  • Effect of hypocholesterolemic agents on central nervous system cholesterol biosynthesis. I. Zuclomiphene [3].
  • CONCLUSIONS: Prospective studies of clomiphene citrate should be performed to confirm the hypothesis that the monitoring of plasma zuclomiphene concentrations can significantly accelerate dose individualization and improve the therapeutic outcome with this "orphan" drug [4].
  • The appropriateness of starting with these low and intermediate intensity treatments is supported by evidence that CC/IUI increases cycle fecundity two- to three-fold, and FSH/IUI, three- to five-fold over the baseline chance of pregnancy in this patient group [5].
  • The combined maximum concentration of enclomiphene and zuclomiphene attained in practice approximates 100 nmol/L and is generally well below levels previously demonstrated to have adverse effects in vitro [6].

Biological context of Clomifene


Anatomical context of Clomifene


Associations of Clomifene with other chemical compounds


Analytical, diagnostic and therapeutic context of Clomifene


  1. Effects of zuclomiphene in combination with triparanol and ay-9944 on developing rat CNS morphology and biochemistry. Ramsey, R.B., Fischer, V.W. Acta Neuropathol. (1977) [Pubmed]
  2. An estrogen receptor model to describe the regulation of prolactin synthesis by antiestrogens in vitro. Lieberman, M.E., Gorski, J., Jordan, V.C. J. Biol. Chem. (1983) [Pubmed]
  3. Effect of hypocholesterolemic agents on central nervous system cholesterol biosynthesis. I. Zuclomiphene. Ramsey, R.B., Fredericks, M. Biochem. Pharmacol. (1977) [Pubmed]
  4. Monitoring plasma concentrations to individualize treatment with clomiphene citrate. Rostami-Hodjegan, A., Lennard, M.S., Tucker, G.T., Ledger, W.L. Fertil. Steril. (2004) [Pubmed]
  5. Stimulated intra-uterine insemination is not a natural choice for the treatment of unexplained subfertility. 'Effective treatment' or 'not a natural choice'? Hughes, E.G. Hum. Reprod. (2003) [Pubmed]
  6. Serum concentrations of enclomiphene and zuclomiphene across consecutive cycles of clomiphene citrate therapy in anovulatory infertile women. Young, S.L., Opsahl, M.S., Fritz, M.A. Fertil. Steril. (1999) [Pubmed]
  7. Effect of clomiphene citrate treatment on endometrial estrogen and progesterone receptor induction in women. Fritz, M.A., Holmes, R.T., Keenan, E.J. Am. J. Obstet. Gynecol. (1991) [Pubmed]
  8. Induction of estrus in anestrous cows treated with 'Fertivet'. Dugwekar, Y.G., Pangawkar, G.R., Sharma, R.D. Theriogenology (1980) [Pubmed]
  9. Chemical inducers of ovulation: comparative results. Ruíz-Velasco, V., Rosas-Arceo, J., Matute, M.M. Int. J. Fertil. (1979) [Pubmed]
  10. Alteration of developing and adult rat muscle membranes by zuclomiphene and other hypocholesterolemic agents. Ramsey, R.B., McGarry, J.D., Fischer, V.W., Sarnat, H.B. Acta Neuropathol. (1978) [Pubmed]
  11. Effects of enclomiphene and zuclomiphene on basal and gonadotrophin-stimulated progesterone secretion by isolated subpopulations of small and large ovine luteal cells. Opsahl, M.S., Fitz, T.A., Rexroad, C.E., Fritz, M.A. Hum. Reprod. (1996) [Pubmed]
  12. Inhibition of ovarian follicle growth by a chemical antiestrogen. Nakano, R., Nakayama, T., Iwao, M. Horm. Res. (1982) [Pubmed]
  13. Critical period of induction by tamoxifen of genital organ abnormalities in female mice. Irisawa, S., Iguchi, T. In Vivo (1990) [Pubmed]
  14. Changes in the uterus and vagina of mice treated neonatally with antiestrogens. Iguchi, T., Todoroki, R., Yamaguchi, S., Takasugi, N. Acta anatomica. (1989) [Pubmed]
WikiGenes - Universities