Chemical Compound Review:
Alond 2-[4-oxo-3-[[5- (trifluoromethyl)benzothiaz...
Synonyms:
Xedia, ZOPOLRESTAT, Zopolrestatum, CHEMBL10372, SureCN49012, ...
- Aldose reductase functions as a detoxification system for lipid peroxidation products in vasculitis. Rittner, H.L., Hafner, V., Klimiuk, P.A., Szweda, L.I., Goronzy, J.J., Weyand, C.M. J. Clin. Invest. (1999)
- Aldose reductase inhibition protects diabetic and nondiabetic rat hearts from ischemic injury. Ramasamy, R., Oates, P.J., Schaefer, S. Diabetes (1997)
- Effect of sorbitol dehydrogenase inhibition on experimental diabetic autonomic neuropathy. Schmidt, R.E., Dorsey, D.A., Beaudet, L.N., Plurad, S.B., Williamson, J.R., Ido, Y. J. Neuropathol. Exp. Neurol. (1998)
- Pharmacokinetics of the aldose reductase inhibitor, zopolrestat, in humans. Inskeep, P.B., Ronfeld, R.A., Peterson, M.J., Gerber, N. Journal of clinical pharmacology. (1994)
- Zopolrestat prevention of proteinuria, albuminuria and cataractogenesis in diabetes mellitus. Beyer-Mears, A., Mistry, K., Diecke, F.P., Cruz, E. Pharmacology (1996)
- Refined 1.8 A structure of human aldose reductase complexed with the potent inhibitor zopolrestat. Wilson, D.K., Tarle, I., Petrash, J.M., Quiocho, F.A. Proc. Natl. Acad. Sci. U.S.A. (1993)
- The response of antioxidant genes to hyperglycemia is abnormal in patients with type 1 diabetes and diabetic nephropathy. Hodgkinson, A.D., Bartlett, T., Oates, P.J., Millward, B.A., Demaine, A.G. Diabetes (2003)
- Molecular modeling of the aldose reductase-inhibitor complex based on the X-ray crystal structure and studies with single-site-directed mutants. Singh, S.B., Malamas, M.S., Hohman, T.C., Nilakantan, R., Carper, D.A., Kitchen, D. J. Med. Chem. (2000)
- Bioavailability, multiple-dose pharmacokinetics, and biotransformation of the aldose reductase inhibitor zopolrestat in dogs. Schneider, R.P., Davenport, C.J., Hoffmaster, K.A., Inskeep, P.B. Drug Metab. Dispos. (1998)
- Tissue distribution and biotransformation of zopolrestat, an aldose reductase inhibitor, in rats. Schneider, R.P., Fouda, H.G., Inskeep, P.B. Drug Metab. Dispos. (1998)
- Pharmacokinetics of zopolrestat, a carboxylic acid aldose reductase inhibitor, in normal and diabetic rats. Inskeep, P.B., Reed, A.E., Ronfeld, R.A. Pharm. Res. (1991)
- Aldose reductase inhibitor zopolrestat restores allergic hyporesponsiveness in alloxan-diabetic rats. Carvalho, V.F., Barreto, E.O., Serra, M.F., Cordeiro, R.S., Martins, M.A., Fortes, Z.B., E Silva, P.M. Eur. J. Pharmacol. (2006)
- Intracellular mechanism of high D-glucose-induced modulation of vascular cell proliferation. Graier, W.F., Grubenthal, I., Dittrich, P., Wascher, T.C., Kostner, G.M. Eur. J. Pharmacol. (1995)
- Aldose reductase inhibition restores endothelial cell function in diabetic rabbit aorta. Tesfamariam, B., Palacino, J.J., Weisbrod, R.M., Cohen, R.A. J. Cardiovasc. Pharmacol. (1993)
- Potent, orally active aldose reductase inhibitors related to zopolrestat: surrogates for benzothiazole side chain. Mylari, B.L., Beyer, T.A., Scott, P.J., Aldinger, C.E., Dee, M.F., Siegel, T.W., Zembrowski, W.J. J. Med. Chem. (1992)
- Kinetic and spectroscopic evidence for active site inhibition of human aldose reductase. Nakano, T., Petrash, J.M. Biochemistry (1996)
- Mechanism of aldose reductase inhibition: binding of NADP+/NADPH and alrestatin-like inhibitors. Ehrig, T., Bohren, K.M., Prendergast, F.G., Gabbay, K.H. Biochemistry (1994)
- Probing the inhibitor-binding site of aldose reductase with site-directed mutagenesis. Hohman, T.C., El-Kabbani, O., Malamas, M.S., Lai, K., Putilina, T., McGowan, M.H., Wane, Y.Q., Carper, D.A. Eur. J. Biochem. (1998)
- 1.7 A structure of FR-1, a fibroblast growth factor-induced member of the aldo-keto reductase family, complexed with coenzyme and inhibitor. Wilson, D.K., Nakano, T., Petrash, J.M., Quiocho, F.A. Biochemistry (1995)
- Interaction between the polyol pathway and non-enzymatic glycation on mesangial cell gene expression. Dan, Q., Wong, R.L., Yin, S., Chung, S.K., Chung, S.S., Lam, K.S. Nephron Exp. Nephrol. (2004)
- Effects of inhibition of the polyol pathway during chronic peritoneal exposure to a dialysis solution. van Westrhenen, R., Aten, J., Aberra, M., Dragt, C.A., Deira, G., Krediet, R.T. Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis. (2005)
- Aldose reductase inhibition improves altered glucose metabolism of isolated diabetic rat hearts. Trueblood, N., Ramasamy, R. Am. J. Physiol. (1998)
- Synthesis, activity, and molecular modeling of new 2, 4-dioxo-5-(naphthylmethylene)-3-thiazolidineacetic acids and 2-thioxo analogues as potent aldose reductase inhibitors. Fresneau, P., Cussac, M., Morand, J.M., Szymonski, B., Tranqui, D., Leclerc, G. J. Med. Chem. (1998)
- Can diabetic neuropathy be prevented by angiotensin-converting enzyme inhibitors? Malik, R.A. Ann. Med. (2000)