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Chemical Compound Review

Multaq     N-[2-butyl-3-[4-[3- (dibutylamino)propoxy]p...

Synonyms: Dronedarone, MET037, CHEMBL184412, SureCN110363, HY-A0016, ...
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Disease relevance of Dronedarone


High impact information on Dronedarone


Chemical compound and disease context of Dronedarone


Biological context of Dronedarone


Anatomical context of Dronedarone


Associations of Dronedarone with other chemical compounds

  • Cmax and AUC0--24 h of metoprolol increased from days 5 to 13 in proportion to dronedarone dose only in CYP2D6 extensive metabolizers genotyped subjects (P < 0.001) [15].

Analytical, diagnostic and therapeutic context of Dronedarone


  1. Dronedarone for prevention of atrial fibrillation: a dose-ranging study. Touboul, P., Brugada, J., Capucci, A., Crijns, H.J., Edvardsson, N., Hohnloser, S.H. Eur. Heart J. (2003) [Pubmed]
  2. Cellular and in vivo electrophysiological effects of dronedarone in normal and postmyocardial infarcted rats. Aimond, F., Beck, L., Gautier, P., Chérif, O.K., Davy, J.M., Lorente, P., Nisato, D., Vassort, G. J. Pharmacol. Exp. Ther. (2000) [Pubmed]
  3. Effects of amiodarone and dronedarone on voltage-dependent sodium current in human cardiomyocytes. Lalevée, N., Nargeot, J., Barrére-Lemaire, S., Gautier, P., Richard, S. J. Cardiovasc. Electrophysiol. (2003) [Pubmed]
  4. Chronic amiodarone-induced inhibition of the Na+-K+ pump in rabbit cardiac myocytes is thyroid-dependent: comparison with dronedarone. Pitt, A.D., Fernandes, C., Bewick, N.L., Hemsworth, P.D., Buhagiar, K.A., Hansen, P.S., Rasmussen, H.H., Delbridge, L., Whalley, D.W. Cardiovasc. Res. (2003) [Pubmed]
  5. Acute effects of dronedarone on both components of the cardiac delayed rectifier K+ current, HERG and KvLQT1/minK potassium channels. Thomas, D., Kathofer, S., Zhang, W., Wu, K., Wimmer, A.B., Zitron, E., Kreye, V.A., Katus, H.A., Schoels, W., Karle, C.A., Kiehn, J. Br. J. Pharmacol. (2003) [Pubmed]
  6. Dronedarone: an emerging agent with rhythm- and rate-controlling effects. Wegener, F.T., Ehrlich, J.R., Hohnloser, S.H. J. Cardiovasc. Electrophysiol. (2006) [Pubmed]
  7. Effects of dronedarone and amiodarone on plasma thyroid hormones and on the basal and postischemic performance of the isolated rat heart. Pantos, C., Mourouzis, I., Delbruyère, M., Malliopoulou, V., Tzeis, S., Cokkinos, D.D., Nikitas, N., Carageorgiou, H., Varonos, D., Cokkinos, D., Nisato, D. Eur. J. Pharmacol. (2002) [Pubmed]
  8. IKr channel blockers: novel antiarrhythmic agents. Lee, K., Park, J.Y., Ryu, P.D., Kwon, L.S., Kim, H.Y. Current medicinal chemistry. Cardiovascular and hematological agents. (2003) [Pubmed]
  9. Involvement of nitric oxide in amiodarone- and dronedarone-induced coronary vasodilation in guinea pig heart. Guiraudou, P., Pucheu, S.C., Gayraud, R., Gautier, P., Roccon, A., Herbert, J.M., Nisato, D. Eur. J. Pharmacol. (2004) [Pubmed]
  10. Hemodynamic and antiadrenergic effects of dronedarone and amiodarone in animals with a healed myocardial infarction. Djandjighian, L., Planchenault, J., Finance, O., Pastor, G., Gautier, P., Nisato, D. J. Cardiovasc. Pharmacol. (2000) [Pubmed]
  11. Electrophysiologic characterization of dronedarone in guinea pig ventricular cells. Gautier, P., Guillemare, E., Marion, A., Bertrand, J.P., Tourneur, Y., Nisato, D. J. Cardiovasc. Pharmacol. (2003) [Pubmed]
  12. Pharmacological inhibition of TRalpha1 receptor potentiates the thyroxine effect on body weight reduction in rats: potential therapeutic implications in controlling body weight. Pantos, C., Mourouzis, I., Paizis, I., Malliopoulou, V., Xinaris, C.h., Moraitis, P., Cokkinos, A.D., Cokkinos, D.V. Diabetes, obesity & metabolism (2007) [Pubmed]
  13. Effects of dronedarone on acetylcholine-activated current in rabbit SAN cells. Altomare, C., Barbuti, A., Viscomi, C., Baruscotti, M., DiFrancesco, D. Br. J. Pharmacol. (2000) [Pubmed]
  14. Amiodarone: a multifaceted antiarrhythmic drug. Singh, B.N. Current cardiology reports. (2006) [Pubmed]
  15. Pharmacokinetic and pharmacodynamic interactions between metoprolol and dronedarone in extensive and poor CYP2D6 metabolizers healthy subjects. Damy, T., Pousset, F., Caplain, H., Hulot, J.S., Lechat, P. Fundamental & clinical pharmacology. (2004) [Pubmed]
  16. Electrophysiological effects of dronedarone (SR 33589), a noniodinated amiodarone derivative in the canine heart: comparison with amiodarone. Varró, A., Takács, J., Németh, M., Hála, O., Virág, L., Iost, N., Baláti, B., Agoston, M., Vereckei, A., Pastor, G., Delbruyère, M., Gautier, P., Nisato, D., Papp, J.G. Br. J. Pharmacol. (2001) [Pubmed]
  17. In vivo and in vitro antiarrhythmic effects of SSR149744C in animal models of atrial fibrillation and ventricular arrhythmias. Gautier, P., Serre, M., Cosnier-Pucheu, S., Djandjighian, L., Roccon, A., Herbert, J.M., Nisato, D. J. Cardiovasc. Pharmacol. (2005) [Pubmed]
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