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Chemical Compound Review

AG-K-68163     2-hydroxy-2-methyl-3-oxo- butanoic acid

Synonyms: CHEBI:16444, HMDB06833, CTK5H0557, AR-1H6480, KB-173029, ...
 
 
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Disease relevance of C00900

 

High impact information on C00900

 

Chemical compound and disease context of C00900

  • To enhance hydrogen (H2) production from glucose by Enterobacter aerogenes HU-101, two mutants, strains VP-1 and VP-2, with decreased alpha-acetolactate synthase activity, were isolated using the Voges-Proskauer (VP) test [10].
 

Biological context of C00900

 

Associations of C00900 with other chemical compounds

 

Gene context of C00900

References

  1. Genetic manipulation of the pathway for diacetyl metabolism in Lactococcus lactis. Swindell, S.R., Benson, K.H., Griffin, H.G., Renault, P., Ehrlich, S.D., Gasson, M.J. Appl. Environ. Microbiol. (1996) [Pubmed]
  2. Cloning and expression of an alpha-acetolactate decarboxylase gene from Streptococcus lactis subsp. diacetylactis in Escherichia coli. Goelling, D., Stahl, U. Appl. Environ. Microbiol. (1988) [Pubmed]
  3. Nucleotide sequence and expression of the Enterobacter aerogenes alpha-acetolactate decarboxylase gene in brewer's yeast. Sone, H., Fujii, T., Kondo, K., Shimizu, F., Tanaka, J., Inoue, T. Appl. Environ. Microbiol. (1988) [Pubmed]
  4. Cloning of aldB, which encodes alpha-acetolactate decarboxylase, an exoenzyme from Bacillus brevis. Diderichsen, B., Wedsted, U., Hedegaard, L., Jensen, B.R., Sjøholm, C. J. Bacteriol. (1990) [Pubmed]
  5. Substrate channeling: alpha-ketobutyrate inhibition of acetohydroxy acid synthase in Salmonella typhimurium. Shaw, K.J., Berg, C.M. J. Bacteriol. (1980) [Pubmed]
  6. The crystal structures of Klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactor and with an unusual intermediate. Pang, S.S., Duggleby, R.G., Schowen, R.L., Guddat, L.W. J. Biol. Chem. (2004) [Pubmed]
  7. Diacetyl and alpha-acetolactate overproduction by Lactococcus lactis subsp. lactis biovar diacetylactis mutants that are deficient in alpha-acetolactate decarboxylase and have a low lactate dehydrogenase activity. Monnet, C., Aymes, F., Corrieu, G. Appl. Environ. Microbiol. (2000) [Pubmed]
  8. Metabolic engineering of Lactococcus lactis: influence of the overproduction of alpha-acetolactate synthase in strains deficient in lactate dehydrogenase as a function of culture conditions. Platteeuw, C., Hugenholtz, J., Starrenburg, M., van Alen-Boerrigter, I., de Vos, W.M. Appl. Environ. Microbiol. (1995) [Pubmed]
  9. Identification and characterization of the alpha-acetolactate synthase gene from Lactococcus lactis subsp. lactis biovar diacetylactis. Marugg, J.D., Goelling, D., Stahl, U., Ledeboer, A.M., Toonen, M.Y., Verhue, W.M., Verrips, C.T. Appl. Environ. Microbiol. (1994) [Pubmed]
  10. High-yield production of hydrogen by Enterobacter aerogenes mutants with decreased alpha-acetolactate synthase activity. Ito, T., Nakashimada, Y., Kakizono, T., Nishio, N. J. Biosci. Bioeng. (2004) [Pubmed]
  11. Application of a ribosomal DNA integration vector in the construction of a brewer's yeast having alpha-acetolactate decarboxylase activity. Fujii, T., Kondo, K., Shimizu, F., Sone, H., Tanaka, J., Inoue, T. Appl. Environ. Microbiol. (1990) [Pubmed]
  12. Cloning and sequencing of the gene encoding alpha-acetolactate decarboxylase from Leuconostoc oenos. Garmyn, D., Monnet, C., Martineau, B., Guzzo, J., Cavin, J.F., Diviès, C. FEMS Microbiol. Lett. (1996) [Pubmed]
  13. Regulation of branched-chain amino acid biosynthesis by alpha-acetolactate decarboxylase in Streptococcus thermophilus. Monnet, C., Nardi, M., Hols, P., Gulea, M., Corrieu, G., Monnet, V. Lett. Appl. Microbiol. (2003) [Pubmed]
  14. Effect of alpha-acetolactate decarboxylase inactivation on alpha-acetolactate and diacetyl production by Lactococcus lactis subsp. lactis biovar diacetylactis. Aymes, F., Monnet, C., Corrieu, G. J. Biosci. Bioeng. (1999) [Pubmed]
  15. Expression of the Oenococcus oeni trxA gene is induced by hydrogen peroxide and heat shock. Jobin, M.P., Garmyn, D., Diviès, C., Guzzo, J. Microbiology (Reading, Engl.) (1999) [Pubmed]
  16. Absence of significant membrane localization of the proteins coded by the ilvGEDAC genes of Escherichia coli K-12. Gray, J.E., Calhoun, D.H. J. Bacteriol. (1982) [Pubmed]
 
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