Chemical Compound Review:
Cilostamida N-cyclohexyl-N-methyl-4-[(2- oxo-1H...
Synonyms:
ciloalamide, cilostamide, Cilostamidum, Lopac-C-7971, Tocris-0915, ...
Ahmad,
Cong,
Stenson Holst,
Wang,
Rahn Landstrom,
Pierce,
Quon,
Degerman,
Manganiello,
Jensen,
Schwinof,
Zelinski-Wooten,
Conti,
DePaolo,
Stouffer,
Sudo,
Tachibana,
Toga,
Tochizawa,
Inoue,
Kimura,
Hidaka,
Yao,
Hiramatsu,
Zhu,
Morioka,
Takeda,
Oite,
Kitamura,
Shimizu,
Murata,
Hiramoto,
Sugiyama,
Nakagawa,
Manganiello,
Tagawa,
- Suppression of arterial intimal hyperplasia by cilostamide, a cyclic nucleotide phosphodiesterase 3 inhibitor, in a rat balloon double-injury model. Inoue, Y., Toga, K., Sudo, T., Tachibana, K., Tochizawa, S., Kimura, Y., Yoshida, Y., Hidaka, H. Br. J. Pharmacol. (2000)
- Potent effects of novel anti-platelet aggregatory cilostamide analogues on recombinant cyclic nucleotide phosphodiesterase isozyme activity. Sudo, T., Tachibana, K., Toga, K., Tochizawa, S., Inoue, Y., Kimura, Y., Hidaka, H. Biochem. Pharmacol. (2000)
- Evidence that insulin and isoprenaline activate the cGMP-inhibited low-Km cAMP phosphodiesterase in rat fat cells by phosphorylation. Degerman, E., Smith, C.J., Tornqvist, H., Vasta, V., Belfrage, P., Manganiello, V.C. Proc. Natl. Acad. Sci. U.S.A. (1990)
- Synergistic inhibition of vascular smooth muscle cell migration by phosphodiesterase 3 and phosphodiesterase 4 inhibitors. Palmer, D., Tsoi, K., Maurice, D.H. Circ. Res. (1998)
- Cyclic nucleotide phosphodiesterase 3B is a downstream target of protein kinase B and may be involved in regulation of effects of protein kinase B on thymidine incorporation in FDCP2 cells. Ahmad, F., Cong, L.N., Stenson Holst, L., Wang, L.M., Rahn Landstrom, T., Pierce, J.H., Quon, M.J., Degerman, E., Manganiello, V.C. J. Immunol. (2000)
- Protein kinase B/Akt induces resumption of meiosis in Xenopus oocytes. Andersen, C.B., Roth, R.A., Conti, M. J. Biol. Chem. (1998)
- Differential expression of cyclic nucleotide phosphodiesterase 3 and 4 activities in human T cell clones specific for myelin basic protein. Ekholm, D., Hemmer, B., Gao, G., Vergelli, M., Martin, R., Manganiello, V. J. Immunol. (1997)
- Complex effects of inhibitors on cyclic GMP-stimulated cyclic nucleotide phosphodiesterase. Yamamoto, T., Yamamoto, S., Osborne, J.C., Manganiello, V.C., Vaughan, M., Hidaka, H. J. Biol. Chem. (1983)
- Antilipolytic action of insulin: role of cAMP phosphodiesterase activation. Elks, M.L., Manganiello, V.C. Endocrinology (1985)
- Inhibition of platelet aggregation by the cAMP-phosphodiesterase inhibitor, cilostamide, may not be associated with activation of cAMP-dependent protein kinase. Nishikawa, M., Komada, F., Morita, K., Deguchi, K., Shirakawa, S. Cell. Signal. (1992)
- Effect of type 3 and type 4 phosphodiesterase inhibitors on the maintenance of bovine oocytes in meiotic arrest. Mayes, M.A., Sirard, M.A. Biol. Reprod. (2002)
- Inhibition of lipopolysaccharide-induced apoptosis by cilostazol in human umbilical vein endothelial cells. Kim, K.Y., Shin, H.K., Choi, J.M., Hong, K.W. J. Pharmacol. Exp. Ther. (2002)
- Purification of the putative hormone-sensitive cyclic AMP phosphodiesterase from rat adipose tissue using a derivative of cilostamide as a novel affinity ligand. Degerman, E., Belfrage, P., Newman, A.H., Rice, K.C., Manganiello, V.C. J. Biol. Chem. (1987)
- Compartmentalization of cAMP signaling in mesangial cells by phosphodiesterase isozymes PDE3 and PDE4. Regulation of superoxidation and mitogenesis. Chini, C.C., Grande, J.P., Chini, E.N., Dousa, T.P. J. Biol. Chem. (1997)
- Characterization of a liver low Michaelis-Menten constant 3',5'-cyclic adenosine monophosphate phosphodiesterase activity sensitive to thyroid status. Benelli, C., Geoffroy, V., Fouque, F., Lopez, S., Desbuquois, B. Endocrinology (1991)
- Selective effects of phosphodiesterase inhibitors on different phosphodiesterases, adenosine 3',5'-monophosphate metabolism, and lipolysis in 3T3-L1 adipocytes. Elks, M.L., Manganiello, V.C. Endocrinology (1984)
- Alterations in EDHF-type relaxation and phosphodiesterase activity in mesenteric arteries from diabetic rats. Matsumoto, T., Kobayashi, T., Kamata, K. Am. J. Physiol. Heart Circ. Physiol. (2003)
- Selective inhibitor of platelet cyclic adenosine monophosphate phosphodiesterase, cilostamide, inhibits platelet aggregation. Hidaka, H., Hayashi, H., Kohri, H., Kimura, Y., Hosokawa, T., Igawa, T., Saitoh, Y. J. Pharmacol. Exp. Ther. (1979)
- Nitric oxide-mediated regulation of connexin43 expression and gap junctional intercellular communication in mesangial cells. Yao, J., Hiramatsu, N., Zhu, Y., Morioka, T., Takeda, M., Oite, T., Kitamura, M. J. Am. Soc. Nephrol. (2005)
- A specific pattern of phosphodiesterases controls the cAMP signals generated by different Gs-coupled receptors in adult rat ventricular myocytes. Rochais, F., Abi-Gerges, A., Horner, K., Lefebvre, F., Cooper, D.M., Conti, M., Fischmeister, R., Vandecasteele, G. Circ. Res. (2006)
- Mouse oocyte meiotic resumption and polar body extrusion in vitro are differentially influenced by FSH, epidermal growth factor and meiosis-activating sterol. Coticchio, G., Rossi, G., Borini, A., Grøndahl, C., Macchiarelli, G., Flamigni, C., Fleming, S., Cecconi, S. Hum. Reprod. (2004)
- Selective inhibition of cGMP-inhibited and cGMP-noninhibited cyclic nucleotide phosphodiesterases and relaxation of rat aorta. Lindgren, S., Rascón, A., Andersson, K.E., Manganiello, V., Degerman, E. Biochem. Pharmacol. (1991)
- Activation of a cGMP-stimulated cAMP phosphodiesterase by protein kinase C in a liver Golgi-endosomal fraction. Geoffroy, V., Fouque, F., Nivet, V., Clot, J.P., Lugnier, C., Desbuquois, B., Benelli, C. Eur. J. Biochem. (1999)
- Phosphodiesterase 3 inhibitors selectively block the spontaneous resumption of meiosis by macaque oocytes in vitro. Jensen, J.T., Schwinof, K.M., Zelinski-Wooten, M.B., Conti, M., DePaolo, L.V., Stouffer, R.L. Hum. Reprod. (2002)
- Expression of cyclic nucleotide phosphodiesterase 3A in isolated rat submandibular acini. Shimizu, K., Murata, T., Hiramoto, K., Sugiyama, T., Nakagawa, T., Manganiello, V.C., Tagawa, T. Arch. Oral Biol. (2006)